Biochemical and crystallographic characterization of homologous non-peptidic thrombin inhibitors having alternate binding modes

Acta Crystallographica Section D: Biological Crystallography

Volumn 54, Issue 6 PART II, 1998, Pages 1207-1215

  Strickland, Corey L ^a   Fevig, John M ^b   Galemmo Jr , Robert A ^b   Wells, Brian L ^b   Kettner, Charles A ^b   Weber, Patricia C ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(N (3 PHENYLPROPIONYL) N (PHENETHYL)) GLYCYL BOROLYSINE; (N-(3-PHENYLPROPIONYL)-N-(PHENETHYL))-GLYCYL-BOROLYSINE; ANTICOAGULANT AGENT; BORON DERIVATIVE; DIPEPTIDE; THROMBIN;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; DRUG ANTAGONISM; ELECTRICITY; ENZYME SPECIFICITY; HUMAN; METABOLISM; PROTEIN BINDING; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ANTICOAGULANTS; BINDING SITES; BORON COMPOUNDS; CRYSTALLOGRAPHY, X-RAY; DIPEPTIDES; ELECTROSTATICS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THROMBIN;

EID: 0032212014     PISSN: 09074449     EISSN: None     Source Type: Journal    
DOI: 10.1107/s0907444997019744     Document Type: Article

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