Structure, Stereochemistry, and Biological Activity of Integramycin, a Novel Hexacyclic Natural Product Produced by Actinoplanes sp. that Inhibits HIV-1 Integrase

Organic Letters

Volumn 4, Issue 7, 2002, Pages 1123-1124

  Singh, Sheo B ^a   Zink, Deborah L ^a   Heimbach, Brian ^a   Genilloud, Olga ^b   Teran, Ana ^b   Silverman, Keith C ^a   Lingham, Russell B ^a   Felock, Peter ^a   Hazuda, Daria J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Medical affairs Merck sharp and Dohme ltd   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRAMYCIN; INTEGRASE INHIBITOR; NAPHTHALENE DERIVATIVE; SPIRO COMPOUND;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; ELECTROSPRAY MASS SPECTROMETRY; FERMENTATION; HUMAN IMMUNODEFICIENCY VIRUS 1; MICROMONOSPORACEAE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

FERMENTATION; HIV INTEGRASE INHIBITORS; HIV-1; MAGNETIC RESONANCE SPECTROSCOPY; MICROMONOSPORACEAE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NAPHTHALENES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPIRO COMPOUNDS;

EID: 0037018483     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol025539b     Document Type: Article

References (9)

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2. (b) Esposito, D.; Craigie, R. Adv. Virus Res. 1999, 52, 319.
3. (a) Hazuda, D. J.; Felock, P.; Witmar, M.; Wolfe, A.; Stillmock, K.; Grobler, J. A.; Espeseth, A.; Gabryelski, L.; Schleif, W.; Blau, C.; Miller, M. D. Science 2000, 287, 646.
4. (b) Wai, J. S.; Egbertson, M. S.; Payne, L. S.; Fisher, T. E.; Embrey, M. W.; Tran, L. O.; Melamed, J. Y.; Langford, H. M.; Guare, J. P.; Zhuang, L.; Grey, V. E.; Vacca, J. P.; Holloway, M. K.; Naylor-Olsen, A. M.; Hazuda, D. J.; Felock, P. J.; Wolfe, A. L.; Stillman, K. A.; Schleif, W.; Gabryelski, L. J.; Young, S. D. J. Med. Chem. 2000, 43, 4923.
5. (c) Neamati, N. Exp. Opin. Invest. Drugs 2001, 10, 281.
6. Singh, S. B.; Zink, D. L.; Goetz, M. A.; Dombrowski, A. W.; Polishook, J. D.; Hazuda, D. L. Tetrahedron Lett. 1998, 39, 2243.
7. (a) Singh, S. B.; Zink, D.; Polishook, J.; Valentino, D.; Shafiee, A.; Silverman, K.; Felock, P.; Teran, A.; Vilella, D.; Hazuda, D. J.; Lingham, R. B. Tetrahedron Lett. 1999, 40, 8775.
8. (b) Singh, S. B.; Felock, P.; Hazuda, D. J. Bioorg. Med. Chem. Lett. 2000, 10, 235.
9. Singh, S. B.; Jayasuriya, H.; Salituro, G. M., Zink, D. L.; Shafiee, A.; Heimbuch, B.; Silverman, K. C.; Lingham, R. B.; Genilloud, O.; Teran, A.; Vilella, D.; Felock, P.; Hazuda, D. J. Nat. Prod. 2001, 64, 874.