Chemical and enzymatic modifications of integric acid and HIV-1 integrase inhibitory activity

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 3, 2000, Pages 235-238

  Singh, Sheo B ^a   Felock, Peter ^a   Hazuda, Daria J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; INTEGRASE INHIBITOR; INTEGRIC ACID; NATURAL PRODUCT; SESQUITERPENOID; SODIUM BOROHYDRIDE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL MODIFICATION; ENZYME ACTIVITY; ENZYME MODIFICATION; HUMAN; HYDROGENATION; INHIBITION KINETICS; NONHUMAN; PARTIAL DRUG SYNTHESIS; REACTION ANALYSIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

AMIDES; CARBOXYLIC ACIDS; HIV INTEGRASE INHIBITORS; HIV-1; HYDROLYSIS; NAPHTHALENES; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0034614999     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00666-6     Document Type: Article

References (7)

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7. Singh, S. B.; Zink, D.; Polishook, J.; Valentino, D.; Shafiee, A.; Silverman, K.; Felock, P.; Teran, A.; Vilella, D.; Hazuda, D. J.; Lingham, R. B. Tetrahedron Lett. 1999, 40, 8775.