Inotropic activity of hydroindene amidinohydrazones

Journal of Medicinal Chemistry

Volumn 45, Issue 1, 2002, Pages 127-136

  Sevillano, L G ^a   Melero, C P ^a   Caballero, E ^a   Tome F ^a   Lelievre L G ^b   Geering, K ^c   Crambert, G ^c   Carron R ^a   Medarde, M ^a   San Feliciano, A ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINOMETHYL 2,3,5,6,7,7A HEXAHYDRO 1H INDEN 5 ONE AMIDINOHYDRAZONE; 4,7A DIMETHYL 5 OXO 2,3,5,6,7,7A HEXAHYDRO 1H INDENE 1 CARBALDEHYDE BIS(AMIDINOHYDRAZONE); 7A METHYL 1 (2 NITROVINYL) 2,3,5,6,7,7A HEXAHYDRO 1H INDEN 5 ONE AMIDINOHYDRAZONE; 7A METHYL 5 OXO 2,3,5,6,7,7A HEXAHYDRO 1H INDENE 1 CARBALDEHYDE BIS(AMIDINOHYDRAZONE); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) INHIBITOR; CARDENOLIDE DERIVATIVE; DIGOXIN; GOMPHOSIDE; HYDRAZONE DERIVATIVE; INDENE DERIVATIVE; INOTROPIC AGENT; ISOENZYME; METHYL (5 AMIDINOHYDRAZONO 4,7A DIMETHYL 2,3,5,6,7,7A HEXAHYDRO 1H INDEN 1 YL)ACRYLATE; METHYL (5 AMIDINOHYDRAZONO 7A METHYL 2,3,5,6,7,7A HEXAHYDRO 1 H INDEN 1 YL)ACRYLATE; N (5 AMINIDONYDRAZONO 7A METHYL 2,3,5,6,7,7A HEXAHYDRO 1H INDEN 1 YLMETHYL)PHTHALIMIDE; STROPHANTHIDIN; UNCLASSIFIED DRUG; UZARIGENIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHRONOTROPISM; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; FEMALE; GUINEA PIG; HEART LEFT ATRIUM; HEART RHYTHM; HEART RIGHT ATRIUM; INOTROPISM; NONHUMAN; RAT; XENOPUS LAEVIS;

AMIDINES; ANIMALS; BIOLOGICAL TRANSPORT; CARDIOTONIC AGENTS; ENZYME INHIBITORS; FEMALE; GUINEA PIGS; HEART; HEART RATE; HUMANS; HYDRAZONES; INDENES; ISOENZYMES; MALE; MYOCARDIAL CONTRACTION; NA(+)-K(+)-EXCHANGING ATPASE; OOCYTES; RATS; TRANSFECTION; XENOPUS LAEVIS;

EID: 0037011903     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0109309     Document Type: Article

References (38)

1. Update on recent clinical trials in congestive heart failure
2. Epidemiology, aetiology, and prognosis of heart failure
3. Treatment of congestive heart failure. Has the time come for decreased complexity?
4. Results of clinical trials with diuretics in congestive heart failure
5. ACE inhibition in cardiovascular disease
6. Consensus recommendations for the management of chronic heart failure
7. Digitalis
8. Digitalis: Its mode of action, receptor, and structure - Activity relationships
9. Ouabain-like factor: Is this the natriuretic hormone?
10. Synthesis of 20α 20β-acetaminado, amino, nitro and hydroxy derivatives of 14-hydroxy-5β14βpregnane-3β-glycosides: Pregnanes that bind to the digitalis receptor
11. +-ATPase: 17β-substituted seco-D-5β-androstane as cassaine analogues
12. Isozymes of the Na-K-ATPase: Heterogeneity in structure, diversity in function
13. Significance of sodium pump isoforms in digitalis therapy
14. Transport and pharmacological properties of nine different human Na,K-ATPase isozymes
15. Identification of a specific role for the Na,K-ATPase alpha 2 isoform as a regulator of calcium in the heart
16. Synthesis and evaluation of cardiotonic activity of diterpenic butenolides
17. Conformational factors in cardiac glycoside activity
18. Synthesis and evaluation of cardiotonic activity of simple butenolides II
19. Hydroindenic-guanylhydrazones. Synthesis and evaluation as inotropic agents
20. Synthesis and inotropic activity of hydroindene derivatives
21. Canthine analogs via intramolecular diels - Alder reactions
22. +-ATPase receptor
23. Cardiac drugs
24. A short, general access to folded all-cis-azatetraquinane ring systems
25. The use of diethyl azodicarboxylate and triphenylphosphine in synthesis and transformation of natural products
26. Progress in the Mitsunobu reaction. A review
27. Stereochemistry of the epoxidations of acyclic allylic amides. Applications towards the synthesis of 2,3,6-trideoxy-3-aminohexoses
28. Análogos sintéticos de cardenolidea con estructura simplificada. Derivados perhidroindénicos
29. One carbon elongation of the hajos - Parrish ketone. Synthesis of (+)-(3aS,7aR)-octahydro-3a-hydroxy-7amethyl-1-methylene-5H-inden-5-one
30. L'utilisation du t-amylate de sodium dans les réctions de Wittig
31. Effects of (S)-nafenodone, a new antidepressant, in isolated guinea-pig atrial and ventricular muscle fibres
32. +-ATPase activity highly sensitive to ouabain
33. Asymmetric synthesis of (+)-(3aS,4S,7aS)-3ahydroxy-4,7a-dimethylperhydroindane-1,5-dione
34. Isolation of impermeable inside-out vesicles from an enriched sarcolemma fraction of rat heart
35. Cardenolide analogs. An explanation for the usual properties of AY 22241
36. 2 terminus of the beta subunit with the alpha subunit