A new approach to the design of novel inhibitors of Na+,K+-ATPase: 17α-substituted seco-D 5β-androstane as cassaine analogues

Journal of Medicinal Chemistry

Volumn 41, Issue 16, 1998, Pages 3033-3040

  De Munari, Sergio ^a   Barassi, Paolo ^a   Cerri, Alberto ^a   Fedrizzi, Giorgio ^a   Gobbini, Mauro ^a   Mabilia, Massimo ^b   Melloni, Piero ^a  

^a Prassis Ist di Ricerche Sigma Tau ^*  (Italy)

^b S IN Soluzioni Informatiche   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

(3BETA HYDROXY 14 OXO 14,15,5BETA ANDROSTANE) 17ALPHA ACRYLIC ACID, 2 (N,N DIMETHYLAMINO)ETHYL ESTER; (3BETA,4 DIHYDROXY 5BETA,14BETA ANDROSTANE) 17ALPHA ACRYLIC ACID,2 (N,N DIMETHYLAMINO)ETHYL ESTER; ADENOSINE TRIPHOSPHATASE INHIBITOR; ANDROSTANE DERIVATIVE; CASSAINE; DIGITOXIGENIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG ACTIVITY; DRUG BINDING; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; INOTROPISM; NONHUMAN;

ALKALOIDS; ANDROSTANES; ANIMALS; BINDING, COMPETITIVE; DIGITALIS; DOGS; DRUG DESIGN; ENZYME INHIBITORS; KIDNEY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR MIMICRY; NA(+)-K(+)-EXCHANGING ATPASE; PLANTS, MEDICINAL; PLANTS, TOXIC; STEREOISOMERISM;

EID: 0032581658     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980108d     Document Type: Article

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