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Volumn 45, Issue 1, 2002, Pages 115-126

7-Substituted 5-amino-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as A2A adenosine receptor antagonists: A study on the importance of modifications at the side chain on the activity and solubility

(8) Baraldi, P G a Cacciari, B a Romagnoli, R a Spalluto, G b Monopoli, A c Ongini, E c Varani, K a Borea, P A a

a UNIVERSITY OF FERRARA (Italy)

b UNIVERSITY OF TRIESTE (Italy)

c Parco Scientifico San Raffaele (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 FURAN 2 YL 7H PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDIN 5 YLAMINE; 4 [3 (5 AMINO 2 FURAN 2 YLPYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDIN 7 YL)ETHYL] N HYDROXYBENZAMIDINE; 5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 5 AMINO 2 (2 FURYL) 7 (3 PHENYLPROPYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 7 [3 (4 AMINOPHENYL)ETHYL] 2 FURAN 2 YL 7H PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDIN 5 YLAMINE; 7 [3 (4 AMINOPHENYL)PROPYL] 2 FURAN 2 YL 7H PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDIN 5 YLAMINE; [5 [3 (5 AMINO 2 FURAN 2 YLPYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDIN 7 YL)PROPYL] 2 HYDROXYMETHYLBENZO[1,3]DIOXOL 2 YL]METHANOL; ADENOSINE A2A RECEPTOR; ADENOSINE A2A RECEPTOR ANTAGONIST; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; AMINE; FURAN; PHENYL GROUP; PYRAZOLE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; WATER;

ANIMAL CELL; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG SYNTHESIS; HYDROPHILICITY; NONHUMAN; PARKINSON DISEASE; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

BINDING, COMPETITIVE; CHROMATOGRAPHY, THIN LAYER; DRUG DESIGN; FURANS; HUMANS; PYRIMIDINES; RADIOLIGAND ASSAY; RECEPTOR, ADENOSINE A2A; RECEPTORS, PURINERGIC P1; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037011899 PISSN: 00222623 EISSN: None Source Type: Journal
DOI: 10.1021/jm010924c Document Type: Article

Times cited : (114)

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