Visible light induced photocleavage of DNA by a mixed-metal supramolecular complex: [{(bpy)2Ru(dpp)}2RhCl2]5+

Inorganic Chemistry

Volumn 41, Issue 24, 2002, Pages 6196-6198

  Swavey, Shawn ^a   Brewer, Karen J ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,2' BIPYRIDINE; CIRCULAR DNA; METAL COMPLEX; OXYGEN; PLASMID DNA; PYRAZINE DERIVATIVE; RHODIUM DERIVATIVE; RUTHENIUM 2,3 BIS(2 PYRIDYL)PYRAZINE; RUTHENIUM DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; DNA CLEAVAGE; EXCITATION; IRRADIATION; LIGHT; MACROMOLECULE;

EID: 0037010943     PISSN: 00201669     EISSN: None     Source Type: Journal    
DOI: 10.1021/ic0257726     Document Type: Article

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43. pUC18 plasmid is 2686 bp (Bayou Biolabs). Irradiation used a 1000 W xenon arc lamp, a water IR filter, and a 475 nm cut off filter. Solutions were 3.5 μM in metal complex and 6.9 mM in phosphate buffer (pH = 7) and allowed for ionic association of the cationic metal complexes with DNA. Dexoygenation was accomplished by bubbling with Ar for 30 min prior to the photolysis of the samples in an airtight cell blanketed with Ar.