Effects of 6α-methylprednisolone acetate on an equine osteochondral fragment exercise model

American Journal of Veterinary Research

Volumn 59, Issue 12, 1998, Pages 1619-1628

  Frisbie, D D ^a   Kawcak, C E ^a   Baxter, G M ^a   Trotter, G W ^a   Powers, B E ^a   Lassen, E D ^a   McIlwraith, C W ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLPREDNISOLONE ACETATE; PROSTAGLANDIN E2; TRIAMCINOLONE ACETONIDE; DRUG DERIVATIVE; GLYCOSAMINOGLYCAN; METHYLPREDNISOLONE; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; ARTICLE; CARPAL BONE; CHONDROPATHY; CONTROLLED STUDY; DRUG EFFECT; EXERCISE; HORSE; INTRAARTICULAR DRUG ADMINISTRATION; NONHUMAN; SYNOVIAL FLUID; SYNOVIUM; ANIMAL; ANIMAL DISEASE; ANIMAL LAMENESS; ARTICULAR CARTILAGE; CHEMISTRY; CYTOLOGY; HORSE DISEASE; INJURY; JOINT; PATHOLOGY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARPAL BONES; CARTILAGE, ARTICULAR; GLYCOSAMINOGLYCANS; HORSE DISEASES; HORSES; INJECTIONS, INTRA-ARTICULAR; JOINTS; LAMENESS, ANIMAL; METHYLPREDNISOLONE; PHYSICAL CONDITIONING, ANIMAL; SYNOVIAL FLUID; SYNOVIAL MEMBRANE;

EID: 0032217172     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Rossdale PD, Hopes R, Digby NJW, et al. Epidemiological study of wastage among racehorses. Vet Rec 1985;116:66-69.
2. Genovese RL. The use of corticosteroids in race track practice, in Proceedings. Symp Effect Corticosteroids Vet Pract, 1983;56-65.
3. Todhunter R, Lust G. Pathophysiology of synovitis: clinical signs and examination in horses. Compend Contin Educ Pract Vet 1990;12:979-992.
4. Wheat JD. The use of hydrocortisone in the treatment of joint and tendon disorders in large animals. J Am Vet Med Assoc 1955;127:64-67.
5. Auer J, Fackelman G. Treatment of degenerative joint disease of the horse - a review and commentary. Vet Surg 1981;2:80-90.
6. Gray R, Gottlieb M. Intra-articular corticosteroids. Clin Orthop 1983;177:235-263.
7. McIlwraith CW. The usefulness and side effects of intra-articular corticosteroids - What do we know?. in Proceedings. Am Assoc Equine Pract 1992;38:21-30.
8. Meagher DM. The effect of intra-articular corticosteroids and continued training on continued carpal chip fractures of horses, in Proceedings. Am Assoc Equine Pract 1979;16:405-412.
9. McKay G, Milne FJ. Observations on the intraarticular use of corticosteroids in the racing thoroughbred. J Am Vet Med Assoc 1976;168:1039-1041.
10. Howell DS. Pathogenesis of osteoarthritis. Am J Med 1986;80:24-28.
11. McIlwraith CW, Vachon A. Review of pathogenesis and treatment of degenerative joint disease. Equine Orthop 1988;(Suppl 6):3-11.
12. Pelletier J, Martel-Pelletier J, Ghandur-Mnaymneh L, et al. Role of synovial membrane inflammation in cartilage matrix breakdown in the pond-nuki dog model of osteoarthritis. Arthritis Rheum 1985;28:554-561.
13. Poole AR. Cartilage in health and disease. In: McCarty DJ, ed. Arthritis and allied conditions: a textbook of rheumatology. 2nd ed. Philadelphia: Lea & Febiger, 1993;279-331.
14. Reife RA, Stuart JM, Hasky KA. The pathological cartilage degradation in human arthritides. In: Woessner FJ, Howell DS, eds. Joint cartilage degradation: basic and clinical aspects. New York: Marcel Dekker Inc, 1993;409-433.
15. Owen R. Intra-articular corticosteroid therapy in the horse. J Am Vet Med Assoc 1980;177:710-713.
16. Mankin HJ, Conger KA. The acute effects of intra-articular hydrocortisone on articular cartilage in rabbits. J Bone Joint Surg 1966;48:1383-1388.
17. Gray RG, Gottlieb NL. Intra-articular corticosteroids: an updated assessment. Clin Orthop 1983;177:235-263.
18. Chunekamrai S, Krook LP, Lust G, et al. Changes in articular cartilage after intraarticular injections of methylprednisolone acetate in horses. Am J Vet Res 1989;50:1733-1741.
19. Behrens F, Shepard N, Mitchell N. Alteration of rabbit articular cartilage by intra-articular injections of glucocorticoids. J Bone Joint Surg 1975;57:70-76.
20. Shoemaker RS, Bertone AL, Martin GS, et al. Effects of intra-articular administration of methylprednisolone acetate on normal articular cartilage and on healing of experimentally induced osteochondral defects in horses. Am J Vet Res 1992;53: 1446-1453.
21. Behrens F, Shepard N, Mitchell N. Metabolic recovery of articular cartilage after intra-articular injections of glucocorticoid. J Bone Joint Surg Am 1976;58:1157-1169.
22. Pelletier JP, Martel-Pelletier J, Cloutier JM, et al. Proteoglycan-degrading acid metalloprotease activity in human osteoarthritic cartilage, and the effect of intraarticular steroid injections. Arthritis Rheum 1987;30:541-548.
23. Williams JN, Brandt KD. Triamcinolone hexacetonide protects against fibrillation and osteophyte formation following chemically induced articular cartilage damage. Arthritis Rheum 1985;28: 1267-1274.
24. Pelletier J, Martell-Pelletier J. Protective effects of corticosteroids on cartilage lesions and osteophyte formation in the pondnuki dog model of OA. Arthritis Rheum 1989;32:181-193.
25. Haraoui B, Pelletier JP, Cloutier JM, et al. Synovial membrane histology and immunopathology in rheumatoid arthritis and osteoarthritis. In vivo effects of antirheumatic drugs. Arthritis Rheum 1991;34:153-163.
26. Allen RC, Gross KR, Laxer RM, et al. Intraarticular triamcinolone hexacetonide in the management of chronic arthritis in children. Arthritis Rheum 1986;29:997-1001.
27. Van Pelt RW, Tillotson PJ, Gertsen KE. Intra-articular injection of betamethasone in arthritis in horses J Am Vet Med Assoc 1970;156:1589-1599.
28. De Vries BJ, van den Berg WB. Impact of NSAIDS on murine antigen induced arthritis. 1. An investigation of anti-inflammatory and chondroprotective effects. J Rheum 1989;16:10-18.
29. Frisbie DD, Kawcak CE, Trotter GW, et al. The effects of triamcinolone acetate on an in vivo equine osteochondral fragment exercise model. Equine Vet J 1997;29:349-359.
30. McIlwraith CW. Diagnostic and surgical arthroscopy in the horse. 2nd ed. Philadelphia: Lea & Febiger, 1990;33-83.
31. Kawcak CE, Frisbie DD, Mcllwraith CW, et al. Effects of intravenous administration of sodium hyaluronate on carpal joints in exercising horses after arthroscopic surgery and osteochondral fragmentation. Am J Vet Res 1997;58:1132-1140.
32. Foland JW, McIlwraith CW, Trotter GW, et al. Effect of betamethasone and exercise on equine carpal joints with osteochondral fragments. Vet Surg 1994;23:369-376.
33. Definition and classification of lameness. In: Guide for veterinary service and judging of equestrian events. Lexington, Ky: Am Assoc Equine Pract, 1991;19.
34. Little CB, Hilbert BJ, Wickstrom S, et al. Quantitative microanalysis of equine synovial fluid glycosaminoglycan concentration. Am J Vet Res 1990;51:1534-1539.
35. Carroll GJ. Spectrophotometric measurement of proteoglycans in osteoarthritic synovial fluid. Ann Rheum Dis 1987;46:375-379.
36. Farndale RW, Sayers CA, Barrett AJ. A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures. Conn Tiss Res 1982;9:247-248.
37. Trotter GW, McIlwraith CW, Yovich JV, et al. Effects of intra-articular administration of methylprednisolone acetate on normal equine articular cartilage. Am J Vet Res 1991;52:83-87.
38. Verschure PJ, van der Kraan PM, Vitters EL, et al. Stimulation of proteoglycan synthesis by triamcinolone acetonide and insulin-like growth factor 1 in normal and arthritic murine articular cartilage. J Rheum 1994;21:920-926.
39. Verbruggen G, Veys EM, Malfait A, et al. Proteoglycan metabolism in tissue cultured human articular cartilage. Influence of piroxicam. J Rheum 1989;16:355-362.
40. Behrens F, Shepard N, Mitchell N Metabolic recovery of articular cartilage after intra-articular injections of glucocorticoid. J Bone Joint Surg Am 1976;58:1157-1160.