Acute synovitis and intra-articular methylprednisolone acetate in ponies

Osteoarthritis and Cartilage

Volumn 6, Issue 2, 1998, Pages 94-105

  Todhunter, Rory J ^a   Fubini, Susan L ^a   Vernier Singer, Margaret ^a   Wootton, Joyce A M ^a   Lust, George ^a   Freeman, Kathleen P ^b   Macleod, James N ^a  

^a Department of Obstetrics Gynecology   (United States)

^b LABORATORY CORPORATION OF AMERICA   (United States)

Author keywords

Cartilage; Corticosteroids; Metabolism; Synovitis

Indexed keywords

COLLAGEN; CORTICOSTEROID; HYALURONIC ACID; HYDROXYPROLINE; INTERLEUKIN 1; LIPOPOLYSACCHARIDE; METHIONINE; METHYLPREDNISOLONE ACETATE; METHYLPREDNISOLONE SODIUM SUCCINATE; MONOMER; PROLINE; PROTEIN; PROTEOGLYCAN; SODIUM SULFATE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL LAMENESS; ANIMAL TISSUE; ARTHROPATHY; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; COLLAGEN SYNTHESIS; CONTROLLED STUDY; EXPLANT; HORSE; JOINT EFFUSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PROTEOGLYCAN SYNTHESIS; SYNOVITIS; SYNOVIUM; WRIST;

EID: 0032031898     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1053/joca.1997.0099     Document Type: Article

References (68)

1. 1. McIlwraith CW. General pathobiology of the joint and response to joint injury. In: Joint Disease in the Horse. McIlwraith CW, Trotter GW, eds. WB Saunders, Philadelphia, 1996, pp. 40-70.
2. 2. Palmer JL, Bertone AL. Joint structure, biochemistry and biochemical disequilibrium in synovitis and equine joint disease. Equine Vet J 1994;26(4):263-77.
3. 3. May SA, Hooke RE, Lees P. Equine chondrocyte activation by a variety of stimuli. Br Vet J 1992;148:389-97.
4. 4. Spiers S, May SA, Bennett D, Edwards GB. Cellular sources of proteolytic enzymes in equine joints. Equine Vet J 1994;26:43-7.
5. 5. Revell PA, Mayston V, Lalor P, Mapp P. The synovial membrane in osteoarthritis: a histological study including the characterisation of the cellular infiltrate present in inflammatory osteoarthritis using monoclonal antibodies. Ann Rheum Dis 1988;47:300-7.
6. 6. Myers SL, Brandt KD, Ehlich JW, Braunstein EM, Shelbourne KD, Heck DA, Kalasinski LA. Synovial inflammation in patients with early osteoarthritis of the knee. J Rheumatol 1990;17:1662-9.
7. 7. Frost L, Ghosh P. Microinjury to the synovial membrane may cause disaggregation of proteogylcans in rabbit knee joint articular cartilage. J Orthop Res 1984;2:207-20.
8. 8. Zvaifler NJ, Boyle D, Firestein GS. Early synovitis -Synoviocytes and mononuclear cells. Semin Arth Rheum 1994;23(6):11-6.
9. 9. May SA, Hooke RE, Lees P. Interleukin-1 stimulation of equine articular cells. Res Vet Sci 1992;52:342-8.
10. 10. Bertone AL, Palmer JL, Jones J. Synovial fluid inflammatory mediators as markers of equine synovitis. Vet Surg 1993;22:372.
11. 11. Arend WP, Joslin FG, Massoni RJ. Characteristics of chondrocyte responses to a human interleukin 1-like factor. Clin Immunol Immunopathol 1985;36:358-70.
12. 12. Ratcliff A, Tyler JA, Hardingham TE. Articular cartilage cultured with interleukin 1. Increased release of link protein, hyaluronate-binding region and other proteoglycan fragments. Biochem J 1986;238:571-80.
13. 13. Morales TI, Hascall VC. Effects of interleukin-1 and lipopolysaccharides on protein and carbohydrate metabolism in bovine articular cartilage organ cultures. Connect Tiss Res 1989;19:255-75.
14. 14. Richardson DW, Dodge GR. Effects of tumor necrosis factor-alpha, interleukin 1-beta and dexamethasone on the matrix metabolism of cultured equine chondrocytes. In: Proceedings 42nd Annual Meeting, Orthopaedic Research Society, February, 1996; Vol. 21:126.
15. 15. Eyre DR, McDevitt CA, Billingham ME, Muir H. Biosynthesis of collagen and other matrix proteins by articular cartilage in experimental osteoarthrosis. Biochem J 1980;188(3):823-37.
16. 16. Lark MW, MacNaul KA, Donatelli S, McDonnell J, Hoerrner LA, Stevens KA, Saphos CA, Bayne EK, Hutchinson NI, Moore VL. Induction of increased levels of proteoglycan fragments in synovial fluid (SF) and increased levels of stromelysin in cartilage, synovium and SF by intraarticular injection of canine monocyte conditioned medium into dogs. J Rheumatol 1994;21:1716-24.
17. 16. Matyas JR, Adams ME, Huang D, Sandell LJ. Discoordinate gene expression of aggrecan and type II collagen in experimental osteoarthritis. Arthritis Rheum 1995;38(3):420-5.
18. 17. Adams ME, Matyas JR, Huang D, Dourado GS. Expression of proteoglycans and collagen in the hypertrophic phase of experimental osteoarthritis. J Rheumatol 1995;22(1):94-7.
19. 18. Palmer J, Bertone Al, Papay RS, Malemud CJ. Effect of experimentally induced acute synovitis on articular cartilage proteoglycan synthesis and composition. In: Proceedings of 40th Annual Meeting, Orthopedic Research Society, 1994;19:480.
20. 19. Fubini SL, Todhunter RJ, Gu DN, MacLeod JN. Synovitis and corticosteroids alter transcription of articular cartilage matrix proteins. Vet Surg 1996;25:425.
21. 20. Pelletier J-P, Haraoui B, Martel-Pelletier J. Modulation of cartilage degradation in arthritic diseases by therapeutic agents. In: Joint Cartilage Degradation: Basic and Clinical Aspects, eds. Woessner, Jr., J.F., Howell, D.S. Marcel Dekker, Inc., New York, NY, pp. 503-528, 1993.
22. 21. Fubini SL, Boatwright A, Todhunter RJ, Lust G. Effect of polysulfated glycosaminoglycan on articular cartilage of equine joints injected with methylprednisolone acetate. Am J Vet Res 1993;54:1359-65.
23. 22. Salber RB, Gross A, Hall JH. Hydrocortisone arthropathy: an experimental investigation. Can Med J 1967;97:374-7.
24. 23. Moskowitz RW, Davis W, Sammarco J, Mast W, Chase SW. Experimentally induced corticosteroid arthropathy. Arthritis Rheum 1970;13:236-43.
25. 23. Verschure PJ, van der Kraan PM, Viters EL, van den Berg W. Stimulation of proteoglycan synthesis by triamcinolone acetonide and insulin-like growth factor 1 in normal and arthritic murine articular cartilage. J Rheumatol 1994;21:920-6.
26. 24. Maier R, Wilhelm G. Preclinical investigations of drug effects in models of osteoarthrosis. In: Effects of drugs on osteoarthrosis. Eds. Muntle E., Bjelle A. Proceedings of 10th European Congress of Rheumatology, Moscow. Berne, Hans Huber, 90-96, 1983.
27. 25. Kalben DA. Chemical models of osteoarthritis: a pharmacological evaluation. J Rheumatol 1987;14(suppl. 14):130-1.
28. 26. Silberberg N, Silberberg R, Hasler N. Fine structure of articular cartilage in mice receiving cortisone acetate. Arch Pathol 1966;82:569-82.
29. 27. Mankin HF, Conger KA. The effects of intra-articular hydrocortisone on articular cartilage in rabbits. J Bone J Surg 1966;48A:1383-8.
30. 28. Behrens F, Shepard N, Mitchell N. Metabolic recovery of articular cartilage after intra-articular injections of glucocorticoid. J Bone J Surg 1976;58A:1157-60.
31. 29. Chunekamrai S, Krook LP, Lust G, Maylin GA. Changes in articular cartilage after injections of methylprednisolone acetate into equine joints. Am J Vet Res 1990;50:1733-41.
32. 30. Trotter GW, McIlwraith CW, Yovich JV, Norrdin RW, Wrigley RH, Lamar CH. Effects of intra-articular administration of methylprednisolone acetate on normal equine articular cartilage. Am J Vet Res 1991;52:83-7.
33. 31. Shoemaker RS, Bertone AL, Martin GS, McIlwraith CW, Roberts ED, Pechman R, Kearney MT. Effects of intra-articular administration of methylprednisolone acetate on normal articular cartilage and on healing of experimentally induced osteochondral defects in horses. Am J Vet Res 1992;53:1446-53.
34. 32. Todhunter RJ, Fubini SL, Wootton JAM, Lust G. Effect of methylprednisolone acetate on proteoglycan and collagen metabolism of articular cartilage explants. J Rhematol 1996;23:1207-13.
35. 33. Jee WSS, Li XJ, Ke HZ, Li M, Smith RJ, Dunn CJ. Application of computer-based histomorphometry to the quantitative analysis of methylprednisolone-treated adjuvant arthritis in rats. Bone Miner 1993;22:221-47.
36. 34. Thonar EJ, Lenz ME, Klintworth GK, Caterson B, Pachman LM, Glickman P, Katz R, Huff J, Kuettner KE. Quantitation of keratan sulfate in blood as a marker of cartilage catabolism. Arthritis Rheum 1985;28:1367-76.
37. 35. Todhunter RJ, Yeager AE, Freeman KP, Parente E, Lust G. Keratan sulfate as a marker of articular cartilage catabolism and joint treatment in ponies. Am J Vet Res 1993;54:1007-16.
38. 36. Todhunter RJ, Fubini SC, Freeman KP, Lust G. Concentrations of keratan sulfate in plasma and synovial fluid from clinically normal horses and horses with joint disease. J Am Vet Med Assoc 1997 (in press).
39. 37. Gogia PP, Brown M, Al-Obaidi S. Hydrocortisone and exercise effects on articular cartilage in rats. Arch Phys Med Rehabil 1993;74:463-7.
40. 38. Meagher DM. The effects of intra-articular corticosteroids and continued training on carpal chip fractures of horses. Proc Am Assoc Equine Pract 1979;16:405-12.
41. 39. Farquhar T, Todhunter RJ, Fubini SL, Burton-Wurster N, Lust L. Effect of methylprednisolone and mechanical loading on canine articular cartilage in explant culture. Osteoarthritis Cart 1996;4:55-62.
42. 40. Poland JW, McIlwraith CW, Trotter GW, Powers BE, Lamar CH. Effect of betamethasone and exercise on equine carpal joints with osteochondral fragments. Vet Surg 1994;23:369-76.
43. 41. Murphy DL, Todhunter RJ, Fubini SL, Lust G. Dose-dependent effects of methylprednisolone on normal and cytokine-challenged equine articular cartilage. Am Assoc Equine Pract 1996;42:126-9.
44. 42. Palmer JL, Bertone AL. Experimentally-induced synovitis as a model for acute synovitis in the horse. Equine Vet J 1994;26(6):492-5.
45. 43. Freeman KP, Todhunter RJ, Lust G. Polychrome-stained equine synovial fluid cytology: comparison with clinical findings, histologic specimens, Wright-Giemsa smears, and clinical outcome. Acta Cytologica 1991;35:512-20.
46. 44. Todhunter RJ, Freeman KP, Yeager A, Lust G. Effect of postoperative exercise and polysulfated glycosaminoglycan on development of osteoarthritis in equine carpal joints with osteochondral defects. Vet Surg 1993;22:330-42.
47. 45. Todhunter PG, Kincaid SA, Todhunter RJ, Baird AN, Hanson RR, Wright JM, Lin H-C, Purohit RC. Immunohistochemical analysis of an equine model of synovitis-induced arthritis. Am J Vet Res 1996;57:1080-93.
48. 46. Burton-Wurster N, Lust G. Fibronectin and proteoglycan synthesis in long-term cultures of cartilage explants in Ham's F12 supplemented with insulin and calcium: effects of addition of TGFβ. Arch Biochem Biophys 1990;283:27-33.
49. 47. Farndale RW, Buttle DJ, Barrett AJ. Improved quantitation and discrimination of sulfated glycosaminoglycans by use of dimethylmethylene blue. Biochim Biophys Acta 1986;883:173-7.
50. 48. MacDonald MH, Benton HP. Cellular responses and receptor mechanisms in joint disease: a bacterial lipopolysaccharide-induced model of articular damage. In: Joint Disease of the Horse, eds. McIlwaith CW, Trotter GW. WB Saunders, Philadelphia, pp. 447-467, 1996.
51. 49. Caterson B, Mahmoodian F, Sorrell JM. Modulation of native chondroitin sulfate structure in tissue development and in disease. J Cell Sci 1990;97:411-7.
52. 50. Floman Y, Eyre DR, Glimcher MJ. Induction of osteoarthrosis in the rabbit knee joint: biochemical studies on the articular cartilage. Clin Orthop 1980;147:278-86.
53. 51. McDevitt CA, Muir H. Biochemical changes in the cartilage of the knee in experimental and natural osteoarthritis in the dog. J Bone J Surg 1976;58:94-101.
54. 52. Frisbie DD, Nixon AJ. Insulin-like growth factor 1 and corticosteroid modulation of chondrocyte metabolic and mitogenic activities in interleukin-1 conditioned equine cartilage. Am J Vet Res 1997;58:524-30.
55. 53. DiBattista JA, Martel-Pelletier J, Antakly T, Tardif G, Cloutier J-M, Pelletier J-P. Reduced expression of glucocorticoid receptor levels in human osteoarthritic chondrocytes. Role in the suppression of metalloprotease synthesis. J Clin Endocrinol Metab 1993;76:1128-34.
56. 54. Cato ACB, Ponta H, Herrlich P. Regulation of gene expression by steroid hormones. Prog Nucleic Acid Res Mol Biol 1992;43:1-36.
57. 55. Zilliacus J, Wright APH, Carlstedt-Duke J, Gustafsson J-A. Structural determinants of DNA-binding specificity by steroid receptors. Mol Endocrinol 1995;9(4):389-400.
58. 56. Diamond MI, Minor JN, Yoshinaga SK, Yamamoto KR. Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. Science 1990;249:1266-72.
59. 57. Jonat C, Rahmsdorf HJ, Park KK, Cato ACB, Gebel S, Ponta H, Herrlich P. Antitumor promotion, anti-inflammation: down-modulation of AP-1 (Fos/ Jun) activity by glucocorticoid hormone. Cell 1990;62:1189-204.
60. 58. Yang-Yen H-F, Chambard J-C, Sun Y-L, Smeal T, Schmidt TJ, Drouin J, Karin M. Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 1990;62:1205-15.
61. 59. Schüle R, Rangarajan P, Kliewer S, Ransone LJ, Bolado J, Yang N, Verma IM, Evans RM. Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell 1990;62:1217-26.
62. 60. Scheinman RI, Cogswell PC, Lofquist AK, Baldwin AS Jr. Role of transcriptional activation of I-kappa Bα in mediation of immunosuppression by glucocorticoids. Science 1995;270:283-6.
63. 61. Auphan N, Didonato JA, Rosetti C, Helmberg A. Karin M. Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of IkB synthesis. Science 1995;270:286-90.
64. 62. Pelletier JP, Martel-Pelletier J, Cloutier JM, Woessner JF. Proteoglycan-degrading acid metalloprotease activity in human osteoarthritic cartilage and the effect of intraarticular steroid injections. Arthritis Rheum 1987;30:541-8.
65. 63. Pelletier J-P, Martel-Pelletier J. Protective effects of corticosteroids on cartilage lesions and osteophyte formation in the Pond-Nuki dog model of osteoarthritis. Arthritis Rheum 1989;32:181-93.
66. 64. Pelletier J-P, Mineau F, Raynauld J-P, Woessner JF, Gunja-Smith Z, Martel-Pelletier J. Intraarticular injections with methylprednisolone acetate reduce osteoarthritic lesions in parallel with chondrocyte stromelysin synthesis in experimental osteoarthritis. Arthritis Rheum 1994;37:414-23.
67. 65. Pelletier JP, DiBattista JA, Raynauld JP, Wilhelm S, Martel-Pelletier J. The in vivo effects of intraarticular corticosteroid injections on cartilage lesions, stromelysin, interleukin-1, and oncogene protein synthesis in experimental osteoarthritis. J Lab Invest 1995;72:578-86.
68. 66. Jafari HS, Saez-Llorens X, Paris M, Rinderknecht S, Friedland I, Ehrett S, Severien C, Olsen KD, Burns DK, Harper CF, Lark MW, Thonar EJ-MA, McCracken GH. Dexamethasone attenuation of cytokine-mediated articular cartilage degradation in experimental lapine haemophilus arthritis. J Infect Dis 1993;168:1186-93.