Molecular simulation reveals structural determinants of the hanatoxin binding in Kv2.1 channels

Journal of Molecular Modeling

Volumn 8, Issue 8, 2002, Pages 253-257

  Shiau, Yu Shuan ^a,c   Lin, Tze Bin ^b   Liou, Horng Huey ^c   Huang, Po Tsarng ^c   Lou, Kuo Long ^c   Shiau, Yuh Yuan ^c  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Docking simulation; Hanatoxin binding; Kv2.1 (drk1); S3C helix; Spatial freedom

Indexed keywords

HANATOXIN; POTASSIUM; TOXIN; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; CONTROLLED STUDY; HYDROPHOBICITY; MEMBRANE POTENTIAL; MOLECULAR INTERACTION; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; STRUCTURE ANALYSIS; TOXIN STRUCTURE;

BINDING SITES; COMPUTER SIMULATION; DELAYED RECTIFIER POTASSIUM CHANNELS; ELECTROSTATICS; HYDROPHOBICITY; MODELS, MOLECULAR; PEPTIDES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN BINDING; SHAB POTASSIUM CHANNELS;

EID: 0036979653     PISSN: 16102940     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00894-002-0095-8     Document Type: Article

References (49)

1. MacKinnon R, Miller C (1989) Science 245:1382-1385
2. MacKinnon R, Yellen G (1990) Science 250:276-279
3. Hartmann HA, Kirsch GE, Drewe JA, Taglialatela M, Joho RH, Brown AM (1991) Science 251:942-944
4. MacKinnon R (1991) Nature 350:232-235
5. Yellen G, Jurman ME, Abramson T, MacKinnon R (1991) Science 251:939-942
6. Yool AJ, Schwarz TL (1991) Nature 349:700-704
7. Liman ER, Tytgat J, Hess P (1992) Neuron 9:861-871
8. Heginbotham L, Lu Z, Abramson T, MacKinnon R (1994) Biophys J 66:1061-1067
9. Ranganathan R, Lewis JH, MacKinnon R (1996) Neuron 16:131-139
10. Armstrong CM, Hille B (1998) Neuron 20:371-380
11. Schrempf H, Schmidt O, Kummerlen R, Hinnah S, Müller D, Betzler M, Steinkamp T, Wagner R (1995) EMBO J 14:5170-5178
12. Doyle DA, Morais-Cabral J, Pfuetzner RA, Kuo A, Morais Gulbis J, Cohen SL, Chait BT, MacKinnon R (1998) Science 280:69-77
13. Liman ER, Hess P, Weaver F, Koren G (1991) Nature 353:752-756
14. Papazian DM, Timpe LC, Jan YN, Jan LY (1991) Nature 349:305-310
15. Perozo E, Santacruz-Toloza L, Stefani E, Bezanilla F, Papazian DM (1994) Biophys J 66:345-354
16. Aggarwal SK, MacKinnon R (1996) Neuron 16:1169-1177
17. Larsson HP, Baker OS, Dhillon DS, Isacoff EY (1996) Neuron 16:387-397
18. Mannuzzu LM, Moronne MM, Isakoff EY (1996) Science 271:213-216
19. Seoh SA, Sigg D, Papazian DM, Bezanilla F (1996) Neuron 16:1159-1167
20. Yang N, George Jr AL, Horn R (1996) Neuron 16:113-122
21. Smith-Maxwell CJ, Ledwell JL, Aldrich RW (1998) J Gen Physiol 111:399-420
22. Smith-Maxwell CJ, Ledwell JL, Aldrich RW (1998) J Gen Physiol 111:421-439
23. Ledwell JL, Aldrich RW (1999) J Gen Physiol 113:389-414
24. Frech GC, van Dongen AM, Schuster G, Brown AM, Joho RH (1989) Nature 340:642-645
25. Papazian DM, Shao XM, Seoh SA, Mock AF, Huang Y, Wainstock DH (1995) Neuron 14:1293-1301
26. Planells-Cases R, Ferrer-Montiel AV, Patten CD, Montal M (1995) Proc Natl Acad Sci USA 92:9422-9426
27. Cha A, Bezanilla F (1997) Neuron 19:1127-1140
28. Tiwari-Woodruff SK, Schulteis CT, Mock AF, Papazian DM (1997) Biophys J 72:1489-1500
29. Cha A, Snyder GE, Selvin PR, Bezanilla F (1999) Nature 402:809-813
30. Monks SA, Needleman DJ, Miller C (1999) J Gen Physiol 113:415-423
31. Li-Smerin Y, Hackos DH, Swartz KJ (2000) J Gen Physiol 115:33-50
32. Li-Smerin Y, Swartz KJ (2000) J Gen Physiol 115:673-684
33. Takahashi H, Kim JI, Min HJ, Sato K, Swartz KJ, Shimada I (2000) J Mol Biol 297:771-780
34. Winterfield JR, Swartz KJ (2000) J Gen Physiol 116:637-644
35. Li-Smerin Y, Swartz KJ (2001) J Gen Physiol 117:205-218
36. Rogers JC, Qu Y, Tanada TN, Scheuer T, Catterall WA (1996) J Biol Chem 271:15950-15962
37. Swartz KJ, Mackinnon R (1997) Neuron 18:675-682
38. Li-Smerin Y, Swartz KJ (1998) Proc Natl Acad Sci USA 95:8585-8589
39. Swartz KJ, Mackinnon R (1995) Neuron 15:941-949
40. Swartz KJ, Mackinnon R (1997) Neuron 18:665-673
41. O'Neil KT, DeGrado WF (1990) Science 250:646-651
42. MacArthur MW, Thornton JM (1991) J Mol Biol 218:397-412
43. Blaber M, Zhang XJ, Matthews BW (1993) Science 260: 1637-1640
44. Mathur R, Zheng J, Yan Y, Sigworth FJ (1997) J Gen Physiol 109:191-199
45. Monne M, Hermansson M, von Heijne G (1999) J Mol Biol 288:141-145
46. Hong KH, Miller C (2000) J Gen Physiol 115:51-58
47. Bezanilla F, Perozo E, Papazian DM, Stefani E (1996) Science 254:679-683
48. Yusaf SP, Wray D, Sivaprasadarao A (1996) Pflüg Arch 433:91-97
49. Huang PT, Liou HH, Lin TB, Chen TY, Spatz HC, Tseng LJ, Shiau YY, Lou KL (2002) Recept Channels 8:79-85