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Volumn 30, Issue SUPPL. 2, 2002, Pages 93-98

Selected biostatistical aspects of the validation of in vitro toxicological assays

Author keywords

In vitro studies; Interlaboratory studies; Statistics; Validation

Indexed keywords

ANIMAL TESTING REPLACEMENT; BIOSTATISTICS; CONFERENCE PAPER; DECISION MAKING; DOSE RESPONSE; IN VITRO STUDY; INTERMETHOD COMPARISON; NONPARAMETRIC TEST; PRIORITY JOURNAL; TOXICITY TESTING; VALIDATION PROCESS;

EID: 0036978503     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119290203002s14     Document Type: Conference Paper
Times cited : (9)

References (32)
  • 1
    • 0030830989 scopus 로고    scopus 로고
    • Statistical analysis of dose-response data from in vitro assays: An illustration using Salmonella mutagenicity data
    • Combes, R.D. (1997). Statistical analysis of dose- response data from in vitro assays: an illustration using Salmonella mutagenicity data. Toxicology in Vitro 11, 683-687.
    • (1997) Toxicology in Vitro , vol.11 , pp. 683-687
    • Combes, R.D.1
  • 2
    • 0032940837 scopus 로고    scopus 로고
    • Issues related to the experimental design and subsequent statistical analysis of in vivo and in vitro comet studies
    • Lovell, D.P., Thomas, G. & Dubow, R. (1999). Issues related to the experimental design and subsequent statistical analysis of in vivo and in vitro comet studies. Teratogenesis Carcinogenesis and Mutagenesis 19, 109-119
    • (1999) Teratogenesis Carcinogenesis and Mutagenesis , vol.19 , pp. 109-119
    • Lovell, D.P.1    Thomas, G.2    Dubow, R.3
  • 3
    • 0011358590 scopus 로고    scopus 로고
    • The statistical analysis of the in vitro chromosome aberration assay using Chinese hamster ovary cells
    • Kim, B.S., Zhao, B., Kim, H.J. & Cho, M. (2000). The statistical analysis of the in vitro chromosome aberration assay using Chinese hamster ovary cells. Mutation Research 469, 243-252.
    • (2000) Mutation Research , vol.469 , pp. 243-252
    • Kim, B.S.1    Zhao, B.2    Kim, H.J.3    Cho, M.4
  • 4
    • 0032922504 scopus 로고    scopus 로고
    • Statistical methods for the Ames Salmonella assay
    • Kim, B.S. & Margolin, B.H. (1999). Statistical methods for the Ames Salmonella assay. Mutation Research 436, 113-122.
    • (1999) Mutation Research , vol.436 , pp. 113-122
    • Kim, B.S.1    Margolin, B.H.2
  • 6
    • 0033982904 scopus 로고    scopus 로고
    • Dose-response and threshold-mediated mechanisms in mutagenesis: Statistical models and study design
    • Lovell, D.P. (2000). Dose-response and threshold-mediated mechanisms in mutagenesis: statistical models and study design. Mutation Research 464, 87-95.
    • (2000) Mutation Research , vol.464 , pp. 87-95
    • Lovell, D.P.1
  • 7
    • 0034113930 scopus 로고    scopus 로고
    • Report and summary of the major conclusions from statistics in genotoxicity testing working group from the International Workshop on Genotoxicity Test Procedures (IWGTP), March 1999
    • Lovell, D.P., Yoshimura, I., Hothorn, L.A., Margolin, B.H. & Soper, K. (2000). Report and summary of the major conclusions from statistics in genotoxicity testing working group from the International Workshop on Genotoxicity Test Procedures (IWGTP), March 1999. Environmental and Molecular Mutagenesis 35, 260-263.
    • (2000) Environmental and Molecular Mutagenesis , vol.35 , pp. 260-263
    • Lovell, D.P.1    Yoshimura, I.2    Hothorn, L.A.3    Margolin, B.H.4    Soper, K.5
  • 9
    • 19244384015 scopus 로고    scopus 로고
    • Statistical planning and analysis considerations in the evaluation of in vitro alternatives to whole animal use for eye irritation testing
    • Feder, P., Carr, G., Holzhütter, H.G., Lovell, D. & Springer, J. (1997). Statistical planning and analysis considerations in the evaluation of in vitro alternatives to whole animal use for eye irritation testing. Food and Chemical Toxicology 35, 167-174.
    • (1997) Food and Chemical Toxicology , vol.35 , pp. 167-174
    • Feder, P.1    Carr, G.2    Holzhütter, H.G.3    Lovell, D.4    Springer, J.5
  • 10
    • 0032875977 scopus 로고    scopus 로고
    • Principal component analysis of tissue scores from substances used in the COLIPA eye irritation validation study
    • Lovell, D.P. (1999). Principal component analysis of tissue scores from substances used in the COLIPA eye irritation validation study. Toxicology in Vitro 13, 491-503.
    • (1999) Toxicology in Vitro , vol.13 , pp. 491-503
    • Lovell, D.P.1
  • 12
    • 2742601432 scopus 로고    scopus 로고
    • Recommendations for the application of biostatistical methods during the development and validation of alternative toxicological methods. ECVAM Biostatistics Task Force Report 1
    • Holzhütter, H-G., Archer, G., Dami, N., Lovell, D.P., Saltelli, A. & Sjöström, M. (1996). Recommendations for the application of biostatistical methods during the development and validation of alternative toxicological methods. ECVAM Biostatistics Task Force Report 1. ATLA 24, 511-530.
    • (1996) ATLA , vol.24 , pp. 511-530
    • Holzhütter, H.-G.1    Archer, G.2    Dami, N.3    Lovell, D.P.4    Saltelli, A.5    Sjöström, M.6
  • 13
    • 77956887333 scopus 로고
    • Recursive nonparametric testing for dose-response relationships subject to downturns at high doses
    • Simpson, D.G. & Margolin, B.H. (1986). Recursive nonparametric testing for dose-response relationships subject to downturns at high doses. Biometrika 73, 589-596.
    • (1986) Biometrika , vol.73 , pp. 589-596
    • Simpson, D.G.1    Margolin, B.H.2
  • 14
    • 0000436702 scopus 로고
    • Adaptive statistical procedures for the analysis of nonmonotone dose-response relationships
    • Schmoor, C. & Schumacher, M. (1992). Adaptive statistical procedures for the analysis of nonmonotone dose-response relationships. Biometrie und Informatik in Medizin und Biologie 23, 113-126.
    • (1992) Biometrie und Informatik in Medizin und Biologie , vol.23 , pp. 113-126
    • Schmoor, C.1    Schumacher, M.2
  • 15
    • 0009663357 scopus 로고
    • A multiple comparison procedure for comparing several treatments with a control
    • Dunnett, C.W. (1955). A multiple comparison procedure for comparing several treatments with a control. Journal of the American Statistical Association 50, 1096-1121.
    • (1955) Journal of the American Statistical Association , vol.50 , pp. 1096-1121
    • Dunnett, C.W.1
  • 16
    • 0040968778 scopus 로고    scopus 로고
    • A unified approach to simultaneous rank test procedures in the unbalanced one-way layout
    • Munzel, U. & Hothorn, L.A. (2001). A unified approach to simultaneous rank test procedures in the unbalanced one-way layout. Biometrical Journal 43, 553-559
    • (2001) Biometrical Journal , vol.43 , pp. 553-559
    • Munzel, U.1    Hothorn, L.A.2
  • 17
    • 0033450725 scopus 로고    scopus 로고
    • Exact unconditional distributions for dichotomous data in many-to-one comparisons
    • Koch, H-F. & Hothorn, L.A. (1999). Exact unconditional distributions for dichotomous data in many-to-one comparisons. Journal of Statistics and Planning Inference 82, 83-99.
    • (1999) Journal of Statistics and Planning Inference , vol.82 , pp. 83-99
    • Koch, H.-F.1    Hothorn, L.A.2
  • 18
    • 0042697233 scopus 로고    scopus 로고
    • Statistical analysis of monotone or non-monotone dose-response data from in vitro toxicological assays
    • in press
    • Bretz, F. & Hothorn, L.A. (2003). Statistical analysis of monotone or non-monotone dose - response data from in vitro toxicological assays. ATLA, in press.
    • (2003) ATLA
    • Bretz, F.1    Hothorn, L.A.2
  • 19
    • 0041695386 scopus 로고    scopus 로고
    • Dose-response and thresholds in mutagenicity studies: A statistical testing approach
    • in press
    • Hothorn, L.A. & Bretz, F. (2003). Dose-response and thresholds in mutagenicity studies: a statistical testing approach. ATLA, in press.
    • (2003) ATLA
    • Hothorn, L.A.1    Bretz, F.2
  • 20
    • 0011358590 scopus 로고    scopus 로고
    • The statistical analysis of the in vitro chromosome aberration assay using Chinese hamster ovary cells
    • Kim, B.S., Zhao, B., Kim, H.J. & Cho, M. (2000). The statistical analysis of the in vitro chromosome aberration assay using Chinese hamster ovary cells. Mutation Research 469, 243-252.
    • (2000) Mutation Research , vol.469 , pp. 243-252
    • Kim, B.S.1    Zhao, B.2    Kim, H.J.3    Cho, M.4
  • 21
    • 0034557649 scopus 로고    scopus 로고
    • Evaluation of animal carcinogenicity studies. Cochran-Armitage trend test vs. multiple contrast tests
    • Hothorn, L.A. & Bretz, F.(2000). Evaluation of animal carcinogenicity studies. Cochran-Armitage trend test vs. multiple contrast tests. Biometrical Journal 42, 553-567
    • (2000) Biometrical Journal , vol.42 , pp. 553-567
    • Hothorn, L.A.1    Bretz, F.2
  • 22
    • 0031668828 scopus 로고    scopus 로고
    • Statistical procedures for estimating the detection limit and determination limit of the Ames Salmonella mutagenicity assay
    • Takanashi, H. & Urano, K. (1998). Statistical procedures for estimating the detection limit and determination limit of the Ames Salmonella mutagenicity assay. Science of the Total Environment 221, 31-42.
    • (1998) Science of the Total Environment , vol.221 , pp. 31-42
    • Takanashi, H.1    Urano, K.2
  • 25
    • 0012962972 scopus 로고    scopus 로고
    • Safety assessment in toxicology studies: Proof of safety versus proof of hazard
    • ed. S.C. Chow & J.P. Liu. New York, NY, USA: Marcel Dekker
    • Hauschke, D. & Hothorn, L.A. (1998). Safety assessment in toxicology studies: proof of safety versus proof of hazard. In Design and Analysis of Animal Studies in Pharmaceutical Development (ed. S.C. Chow & J.P. Liu), pp. 197-226. New York, NY, USA: Marcel Dekker.
    • (1998) Design and Analysis of Animal Studies in Pharmaceutical Development , pp. 197-226
    • Hauschke, D.1    Hothorn, L.A.2
  • 26
    • 85138941649 scopus 로고    scopus 로고
    • The role of control groups in mutagenicity studies: Matching biological and statistical relevance
    • in press
    • Hauschke, D. & Hothorn, L.A. (2003). The role of control groups in mutagenicity studies: matching biological and statistical relevance. ATLA, in press.
    • (2003) ATLA
    • Hauschke, D.1    Hothorn, L.A.2
  • 27
    • 0032856082 scopus 로고    scopus 로고
    • The validation and acceptance of alternatives to animal testing
    • Balls, M. & Fentem, J.H. (1999). The validation and acceptance of alternatives to animal testing. Toxicology in Vitro 13, 837-846.
    • (1999) Toxicology in Vitro , vol.13 , pp. 837-846
    • Balls, M.1    Fentem, J.H.2
  • 28
    • 0042196050 scopus 로고    scopus 로고
    • Statistics of interlaboratory in vitro toxicological studies
    • in press
    • Hothorn, L.A. (2003). Statistics of interlaboratory in vitro toxicological studies. ATLA, in press.
    • (2003) ATLA
    • Hothorn, L.A.1
  • 29
    • 0032579169 scopus 로고    scopus 로고
    • Comparison of responses of base-specific Salmonella tester strains with the traditional strains for identifying mutagens: The results of a validation study
    • Gee, P., Sommers, C.H., Melick, A.S., Gidrol, X.M., Todd, M.D., Burris, R.B., Nelson, M.E., Klemm, R.C. & Zeiger, E. (1998). Comparison of responses of base-specific Salmonella tester strains with the traditional strains for identifying mutagens: the results of a validation study. Mutation Research 412, 115-30.
    • (1998) Mutation Research , vol.412 , pp. 115-130
    • Gee, P.1    Sommers, C.H.2    Melick, A.S.3    Gidrol, X.M.4    Todd, M.D.5    Burris, R.B.6    Nelson, M.E.7    Klemm, R.C.8    Zeiger, E.9
  • 30
    • 0042697276 scopus 로고    scopus 로고
    • Biostatistical methods for the validation of alternative methods for the in vitro toxicity testing
    • in press
    • Edler, L. & Ittrich, C. (2003). Biostatistical methods for the validation of alternative methods for the in vitro toxicity testing. ATLA, in press.
    • (2003) ATLA
    • Edler, L.1    Ittrich, C.2
  • 32
    • 12244264237 scopus 로고    scopus 로고
    • Diagnostic test evaluation without a gold standard
    • ed. M.H. Gail & J. Benichou. New York, NY, USA: John Wiley
    • De Bock, G.H. & Houweling, J.C. (2000). Diagnostic test evaluation without a gold standard. In Encyclopedia of Epidemiologic Methods (ed. M.H. Gail & J. Benichou), pp. 301-303. New York, NY, USA: John Wiley.
    • (2000) Encyclopedia of Epidemiologic Methods , pp. 301-303
    • De Bock, G.H.1    Houweling, J.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.