Statistical planning and analysis considerations in the evaluation of in vitro alternatives to whole animal use for eye irritation testing

Food and Chemical Toxicology

Volumn 35, Issue 1, 1997, Pages 167-174

  Feder, P ^d   Carr, G ^a   Holzhutter H G ^b   Lovell, D ^d   Springer, J ^c  

^a PROCTER AND GAMBLE COMPANY   (United States)

^b HUMBOLDT UNIVERSITY   (Germany)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

IRRITANT AGENT; SURFACTANT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CONFERENCE PAPER; EYE IRRITATION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; NONHUMAN; STANDARDIZATION; STATISTICAL ANALYSIS; TOXICITY TESTING;

ANIMALIA;

EID: 19244384015     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(96)00108-1     Document Type: Conference Paper

References (6)

1. American Society for Testing and Materials (1988) Standard practice for conducting an interlaboratory study to determine the precision of a test method. ASTM Standard Practice E 691-87. Annual Book of ASTM Standards.
2. Feder P. I. et al. (1991) The CTFA Evaluation of Alternatives Program: An Evaluation of In Vitro Alternatives to the Draize Primary Eye Irritation Test. (Phase I) Hydroalcoholic Formulations; (Part 1) Statistical Methods. In Vitro Toxicology 4, 231-246.
3. Gettings S. D. et al. (1990) The CTFA Evaluation of Alternatives Program: An Evaluation of In Vitro Alternatives to the Draize Primary Eye Irritation Test. (Phase I) Hydroalcoholic Formulations; Preliminary Communication. In Vitro Toxicology 3, 293-302.
4. Gettings S. D. et al. (1991) The CTFA Evaluation of Alternatives Program: An Evaluation of In Vitro Alternatives to the Draize Primary Eye Irritation Test. (Phase I) Hydroalcoholic Formulations; (Part 2) Data Analysis and Biological Significance. In Vitro Toxicology 4, 247-288.
5. Gettings S. D. et al. The CTFA Evaluation of Alternatives Program. Presented at World Congress on Animal Use and Alternatives in the Life Sciences: Education, Research, and Testing. Johns Hopkins University, Baltimore, MD.
6. Hahn G. J. and Meeker W. Q. (1991) Statistical Intervals. John Wiley & Sons. New York.