An assessment of docosahexaenoic acid intake from the viewpoint of safety and physiological efficacy in matured rats

Annals of Nutrition and Metabolism

Volumn 46, Issue 5, 2002, Pages 176-181

  Saito, Morio ^a   Kubo, Kazuhiro ^a  

^a NATIONAL INSTITUTE OF HEALTH AND NUTRITION   (Japan)

Author keywords

Tocopherol; Docosahexaenoic acid; Intake assessment; Lipid peroxidation; Serum lipid

Indexed keywords

ALKADIENE; ALPHA TOCOPHEROL; ANTIOXIDANT; DOCOSAHEXAENOIC ACID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID PEROXIDASE; LIPID PEROXIDE; LIVER ENZYME; PHOSPHOLIPID; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD CHEMISTRY; CHEMOLUMINESCENCE; CHOLESTEROL BLOOD LEVEL; CONJUGATE; CONTROLLED STUDY; FAT INTAKE; FOOD COMPOSITION; LIPID BLOOD LEVEL; LIPID PEROXIDATION; LIVER LEVEL; LIVER MICROSOME; MALE; MATURATION; NONHUMAN; PHOSPHOLIPID BLOOD LEVEL; PHYSIOLOGY; PRIORITY JOURNAL; RAT; TISSUE DISTRIBUTION; TRIACYLGLYCEROL BLOOD LEVEL;

AGING; ALPHA-TOCOPHEROL; ANIMALS; ANTIOXIDANTS; CHEMILUMINESCENT MEASUREMENTS; DOCOSAHEXAENOIC ACIDS; LIPID PEROXIDATION; LIPID PEROXIDES; LIPIDS; LIPOFUSCIN; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY; THIOBARBITURATES;

EID: 0036969758     PISSN: 02506807     EISSN: None     Source Type: Journal    
DOI: 10.1159/000065404     Document Type: Article

References (40)

1. Grundy SM, Denke MA: Dietary influences on serum lipids and lipoproteins. J Lipid Res 1990;31:1149-1172.
2. Stehbens WE: Diet and atherogenesis. Nutr Rev 1989,47:1-12.
3. Nordoy A, Goodnight SH: Dietary lipids and thrombosis. Relationships to atherosclerosis. Arteriosclerosis 1990;10:149-163.
4. Dyberg J: Linolenate-derived polyunsaturated fatty acids and prevention of atherosclerosis. Nutr Rev 1986;44:125-134.
5. Herold PM, Kinsella JE: Fish oil consumption and decreased risk of cardiovascular disease: A comparison of findings form animal and human feeding trials. Am J Clin Nutr 1986;43:566-598.
6. Harris WS: Fish oils and plasma lipid and lipoprotein metabolism in humans: A critical review. J Lipid Res 1989,30:785-807.
7. Nestel PJ: Effects of n-3 fatty acids on lipid metabolism. Annu Rev Nutr 1990;10:149-167.
8. Simopoulos AP: Omega-3 fatty acids in health and disease and in growth and development. Am J Clin Nutr 1991;54:438-463.
9. Drevon CA: Marine oils and their effects. Nutr Rev 1992;50:38-45.
10. Lands WEM: Biochemistry and physiology of n-3 fatty acids. FASEB J 1992;6:2530-2536.
11. Hammer CT, Wills ED: The role of lipid components of the diet in the regulation of the fatty acid composition of the rat liver endoplasmic reticulum and lipid peroxidation. Biochem J 1978;174:585-593.
12. Mouri K, Ikesu H, Esaka T, Igarashi O: The influence of marine oil intake upon levels of lipids, alpha-tocopherol and lipid peroxidation in serum and liver of rats. J Nutr Sci Vitaminol 1984;30:307-318.
13. Hu M-L, Frankel EN, Leibovitz BE, Tappel AL: Effect of dietary lipids and vitamin E on in vitro lipid peroxidation in rat liver and kidney homogenates. J Nutr 1989;119:1574-1582.
14. Kaasgaard SG, Holmer G, Hoy C-E, Behrens WA, Beare-Rogers JL: Effects of dietary linseed oil and marine oil on lipid peroxidation in monkey liver in vivo and in vitro. Lipids 1992;27:740-745.
15. Saito M, Kubo K, Ikegami S: An assessment of docosahexaenoic acid (DHA) intake with special reference to lipid metabolism in rats. J Nutr Sci Vitaminol 1996;42:195-207.
16. Meydani M, Natiello F, Golden B, Free N, Woods M, Schaefer E, Blumberg JB, Gorbachi SL: Effect of long-term fish oil supplementation on vitamin E status lipid peroxidation in women. J Nutr 1991;121:484-491.
17. Kubo K, Saito M, Tadokoro T, Maekawa A: Changes in susceptibility of tissues to lipid peroxidation after ingestion of various levels of docosahexaenoic acid and vitamin E. Br J Nutr 1997;78:655-669.
18. Kubo K, Saito M, Tadokoro T, Maekawa A: Docosahexaenoic acid dose not promote lipid peroxidation in rat tissue to the extent expected from peroxidizability index of the lipid. Biosci Biotechnol Biochem 1998;62:1698-1706.
19. Kubo K, Saito M, Tadokoro T, Maekawa A: Preferential incorporation of docosahexaenoic acid into nonphosphorus lipids and phosphatidylethanolamine protects rats from dietary DHA-stimulated lipid peroxidation. J Nutr 2000;130:1749-1759.
20. Saito M, Iwamoto T, Kaga A, Matsumoto A, Itakura H: An assessment of appropriate vitamin E content in fish oil capsules as estimated by lipid peroxide and vitamin E levels in human blood. J Clin Biochem Nutr 1999;26:35-50.
21. American Institute of Nutrition: Second report of the Ad Hoc Committee on standards for nutritional studies. J Nutr 1980;110:1726.
22. Pietrangelo A, Grandi R, Tripodi A, Tomasi A, Ceccarelli D, Ventura E, Masini A: Lipid composition and fluidity of liver mitochondria, microsomes and plasma membrane of rats with chronic dietary iron overload. Biochem Pharmacol 1990;39:123-128.
23. Rao KS, Recknagel RO: Early onset of lipoperoxidation in rat liver after carbon tetrachloride administration. Exp Mol Pathol 1968;9:271-278.
24. Yagi K: A simple fluorometric assay for lipoperoxide in blood plasma. Biochem Med 1976;15:212-216.
25. Ohkawa H, Ohishi N, Yagi K: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351-358.
26. Miyazawa T, Tsuchida K, Kaneda T: Riboflavin tetrabutyrate: An antioxidative synergist of alfa-tocopherol as estimated by hepatic chemiluminescence. Nutr Rep Intern 1984;29:157-165.
27. Tuchida M, Miura T, Mizutani K, Aibara K: Fluorescent substances in mouse and human sera as a parameter of in vivo lipid peroxidation. Biochim Biophys Acta 1985;834:196-204.
28. Saito M, Yamaguchi M: Influence of excessive ascorbic acid dose on liver microsomal mixed function oxidase system in guinea pigs. J Clin Biochem Nutr 1988;4:123-137.
29. Fletcher BL, Dillard CJ, Tappel AL: Measurement of fluorescent lipid peroxidation products in biological systems and tissues. Anal Biochem 1973;52:1-9.
30. Saito M, Nakatsugawa K, Oh-hashi A, Nishimuta M, Kodama N: Comparison of vitamin E levels in human plasma, red blood cells, and platelets following varying intakes of vitamin E. J Clin Biochem Nutr 1992;12:59-68.
31. Duncan DB: Multiple range tests for correlated and heteroscedastic means. Biometrics 1957;13:164-176.
32. Dillard CJ, Tappel AL: Fluorescent products of lipid peroxidation of mitochondria and microsomes. Lipids 1971;6:715-721.
33. Rabbani PI, Sheikh NM, Chirtel SJ, Jackson R, Ruffin G: Effects of long-term consumption of high doses of fish oil concentrates on clinical parameters in male and female rats. J Nutr Sci Vitaminol 1999;45:553-565.
34. Boswell K, Koskelo E-K, Carl L, Glaza S, Hensen DJ, Williams KD, Kyle DJ: Preclinical evaluation of single-cell oils that are highly enriched with arachidonic acid and docosahexaenoic acid. Food Chem Toxicol 1996;34:585-593.
35. Wibert GJ, Burns RA, Diersen-Schade DA, Kelly CM: Evaluation of single cell sources of docosahexaenoic acid and arachidonic acid: A 4-week oral safety study in rats. Food Chem Toxicol 1997;35:967-974.
36. Kobatake Y, Kuroda K, Jinnouchi H, Nishide E, Innami S: Differential effects of dietary eicosapentaenoic and docosahexaenoic fatty acids on lowering of triglyceride and cholesterol levels in the serum of rats on hypercholesterolemic diet. J Nutr Sci Vitaminol 1984;30:357-372.
37. Ikeda I, Wakamatsu K, Inayoshi A, Imaizumi K, Sugano M, Yazawa K: Alpha-linolenic, eicosapentaenoic and docosahexaenoic acids affect lipid metabolism differently in rats. J Nutr 1994;124:1898-1906.
38. Yamada N, Kobatake Y, Ikegami S, Takita T, Wada M, Shimizu J, Kanke Y, Innami S: Changes in blood coagulation, platelet aggregation, and lipid metabolism in rats given lipids containing docosahexaenoic acid. Biosci Biotech Biochem 1997;61:1454-1458.
39. Cosgrove JP, Church DF, Pryor WA: The kinetics of the autoxidation of polyunsaturated fatty acids. Lipids 1987;22:299-304.
40. Sugano M, Hirahara F: Polyunsaturated fatty acids in the food chain in Japan. Am J Clin Nutr 2000;71(suppl):189S-196S.