Structure-activity relationships of flavonoids, isolated from Scutellaria baicalensis, binding to benzodiazepine site of GABAA receptor complex

Planta Medica

Volumn 68, Issue 12, 2002, Pages 1059-1062

  Wang, Hongyan ^a,b   Hui, Kwok Min ^b   Chen, Yingjie ^a   Xu, Suixu ^a   Wong, J Tze Fei ^b   Xue, Hong ^b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

BDZ receptor ligands; Flavonoids; Lamiaceae; Scutellaria baicalensis; Structure activity relationship

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 5,7,2' TRIHYDROXY 6,8 DIMETHOXYFLAVONE; DIAZEPAM; FLAVONOID; FLUNITRAZEPAM; LIGAND; SCUTELLARIA BAICALENSIS EXTRACT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONTROLLED STUDY; DRUG BINDING; DRUG BINDING SITE; DRUG DESIGN; DRUG ISOLATION; DRUG POTENCY; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; NONHUMAN; PLANT ROOT; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT;

ANIMALS; APIGENIN; BINDING SITES; FLAVANONES; FLAVONOIDS; FLUNITRAZEPAM; GABA MODULATORS; GLUCURONIC ACIDS; MOLECULAR STRUCTURE; PLANT EXTRACTS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SCUTELLARIA BAICALENSIS;

ANIMALIA; LAMIACEAE; SCUTELLARIA; SCUTELLARIA BAICALENSIS;

EID: 0036969504     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2002-36357     Document Type: Article

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