Anxiolytic natural and synthetic flavonoid ligands of the central benzodiazepine receptor have no effect on memory tasks in rats

Pharmacology Biochemistry and Behavior

Volumn 58, Issue 4, 1997, Pages 887-891

  Salgueiro, J B ^a   Ardenghi, P ^a   Dias, M ^a   Ferreira, M B C ^a   Izquierdo, I ^a   Medina, J H ^b  

^a Depto Bioquim ICBS Univ F   (Brazil)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Anxiolytic action; Apigenin; Chrysin; Diazepam; Dinitroflavone; Effects on analgesia; Effects on memory; Quercetin

Indexed keywords

APIGENIN; BENZODIAZEPINE RECEPTOR; CHRYSIN; DIAZEPAM; FLAVONOID; QUERCETIN;

ANALGESIA; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HABITUATION; LEARNING; MALE; MEMORY; NONHUMAN; OPEN FIELD BEHAVIOR; PRIORITY JOURNAL; RAT; TRAINING;

ANIMALS; ANTI-ANXIETY AGENTS; AVOIDANCE LEARNING; CHAMOMILE; DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FLAVONOIDS; LIGANDS; MALE; MEMORY; OILS, VOLATILE; PLANTS, MEDICINAL; PSYCHOMOTOR PERFORMANCE; QUERCETIN; RATS; RATS, WISTAR; REACTION TIME; RECEPTORS, GABA-A;

EID: 0031415450     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(97)00054-3     Document Type: Article

References (15)

1. Greenblatt D. J., Shader R. I., Abernethy D. R. Current status of benzodiazepines. N. Engl. J. Med. 309:1983;354-358.
2. Izquierdo I., Fin C., Schmitz P. K., Da Silva R. C., Jerusalinsky D., Quillfeldt J. A., Ferreira M. B. C., Medina J. H., Bazan N. G. Memory enhancement by intra-hippocampal, intra-amygdala or intra-entorhinal infusion of platelet-activating factor. Proc. Natl. Acad. Sci. USA. 92:1995;5047-5051.
3. Izquierdo I., Pereira M. E., Median J. H. Benzodiazepine ligand influences on acquisition. Suggestions of an endogenous modulatory mechanism mediated by benzodiazepine receptors Behav. Neural Biol. 54:1990;27-41.
4. Marder M., Viola H., Wasowski C., Wolfman C., Waterman P. G., Medina J. H., Paladini A. C. 6,3′-Dinitroflavone, a novel high afinity ligand for the venzodiazepine receptor with potent anxiolytic properties. Bioorganic Med. Chem. Lett. 5:1995;2717-2720.
5. Marder M., Viola H., Wasowski C., Wolfman C., Waterman P., Cassels B. K., Medina J. H., Paladini A. C. 6-Bromoflavone, a high affinity ligand for the central benzodiazepine receptors is a member of a family of active flavonoids. Biochem. Biophys. Res. Commun. 223:1996;384-389.
6. Martin J. R., Haefely W. E. Drugs used for the treatment of anxiety and sleep disorders. Munson P. L. Principles of pharmacology. 1995;243-278 Chapman & Hall, New York.
7. Medina J. H., Paladini A. C., Wolfman C., Levi de Stein M., Calvo L. E., Peña D. Chrysin (5,7,-di-HO-Flavone), a naturally-occurring ligand for benodiazepine receptors with anticonvulsant properties. Biochem. Pharmacol. 40:1990;2227-2232.
8. Pellow S., Chopin P., File S. H., Briley M. Validation of open:closed arm entries in the elevated plus maze as a measure of anxiety in the rat. J. Neurosci. Methods. 14:1985;149-167.
9. Pereira M. E., Rosat R., Huang C. H., Godoy M. G. C., Izquierdo I. Inhibition by diazepam of the effect of additional training and of extinction on the retention of shuttle avoidance behavior in rats. Behav. Neurosci. 103:1993;202-205.
10. Salgueiro, J. B.: Estudos psicofarmacológicos com quercetina, 52 pp. Master's Thesis, Universidade Federal do Rio Grande do Sul (UFRGS); 1996.
11. Siegfried B., Netto C. A., Izquierdo I. Exposure to novelty induces naltrexone-Reversible analgesia in rats. Behav. Neurosci. 101:1987;436-438.
12. Viola H., Wolfman C., Levi de Stein M., Wasowski C., Peña C., Median J. H., Paladini A. C. Isolation of pharmacologically active benozodiazepine receptor ligands from Tilia tomentosa (Tiliaceae). J. Ethnopharmacol. 44:1994;47-53.
13. Viola H., Wasowski C., Levi de Stein M., Wolfman C., Silveira R., Dejas F., Medina J. H., Paladini A. C. Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. Planta Med. 61:1995;213-216.
14. Wolfman C., Viola H., Paladini A., Dajas F., Median J. H. Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora coerulea. Pharmacol. Biochem. Behav. 47:1994;1-4.
15. Wolfman, C.; Viola, H.; Marder, M.; Ardenghi, P.; Wasowski, C.; Izquierdo, I.; Paladini, A. C.; Medina, J. H.: Anxioselective properties of 6,3′-dinitroflavone, a high affinity benzodiazepine receptor ligand. Eur. J. Pharmacol. (in press).