6-bromoflavone, a high affinity ligand for the central benzodiazepine receptors is a member of a family of active flavonoids

Biochemical and Biophysical Research Communications

Volumn 223, Issue 2, 1996, Pages 384-389

  Marder, Mariel ^a   Viola, Haydee ^b   Wasowski, Cristina ^a   Wolfman, Claudia ^b   Waterman, Peter G ^c   Cassels, Bruce K ^d   Medina, Jorge H ^b   Paladini, Alejandro C ^a  

^a Instituto de Quimica y Fisicoquimica Biologicas Buenos Aires   (Argentina)

^b Facultad de Medicina   (Argentina)

^c UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^d UNIVERSITY OF CHILE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE RECEPTOR; FLAVONE DERIVATIVE; FLAVONOID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BROMINATION; CONTROLLED STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; TRANQUILIZING ACTIVITY;

ANIMALIA;

EID: 0004396593     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.1996.0903     Document Type: Article

References (15)

1. 1. Medina, J. H., Paladini, A. C., Wolfman, C., Levi de Stein, M., Calvo, D., Diaz, L. E., and Peña, C. (1990) Biochem. Pharmacol. 40, 2227-2231.
2. 2. Wolfman, C., Viola, H., Paladini, A. C., Dajas, F., and Medina, J. H. (1994) Pharmacol. Biochem. Behav. 47, 1-4.
3. 3. Viola, H., Wasowski, C., Levi de Stein, M., Wolfman, C., Silveira, R., Dajas, F., Medina, J. H., and Paladini, A. C. (1995) Planta Medica 61, 213-216.
4. 4. Sternbach, L. H. (1978) Prog Drug Res. 22, 229-266.
5. 5. Medina, J. H., and De Robertis, E. (1985) J. Neurochem 44, 1340-1344.
6. 6. Levi de Stein, M., Medina, J. H., and De Robertis, E. (1989) Mol. Brain Res. 5, 9-15.
7. 7. Quader, A., Gray, A. I., Waterman, P. G., Lavaud, C., Massiot, G., and Sadler, I. H. (1991) Tetrahedron 47, 3611-3620.
8. 8. Bax, A., and Summers, M. F. (1986) J. Am. Chem. Soc. 108, 2093-2094.
9. 9. Braestrup, C., Schmiechen, R., Neef, E., Nielsen, M., and Petersen, E. N. (1982) Science 216, 1241-1243.
10. 10. Viola, H., Wolfman, C., Levi de Stein, M., Wasowski, C., Peña, C., Medina, J. H., and Paladini, A. C. (1994) J. Ethnopharmacol. 44, 47-53.
11. 11. Marder, M., Viola, H., Wasowski, C., Wolfman, C., Waterman, P. G., Medina, J. H., and Paladini, A. C. Phytomedicine (in press).
12. 12. Shen, X. L., Nielsen, M., Witt, M. R., Sterner, O., Bergendorff, O., and Khayyal, M. (1994) Acta Pharmacologica Sinica 15, 5-8.
13. 13. Häberlein, H., Tschiersch, K. P., and Schäfer, L. (1994) Pharmazie 49, 912-922.
14. 3, 300 MHz) of compound 15 (Table 1): δ 7.86 (2H, m, H-2′, H-6′), 7.48 (3H, m, H-3′, H-4′, H-5′), 6.67 (1H, s, H-3), 6.56 (1H, d, J = 2.2 Hz, H-8), 6.37 (1H, d, J = 2.2 Hz, H-6), 3.95, 3.90 (2×3H, 2×s, 2×OMc).
15. 15. Marder, M., Viola, H., Wasowski, C., Wolfman, C., Waterman, P. G., Medina, J. H., and Paladini, A. C. (1995) Bioorg. Med. Chem. Lett. 5, 2717-2720.