Activation of the phosphatidylinositol-3′-kanase/protein kinase B-dependent antiapoptotic pathway plays an important role in the development of radioresistance of human glioma cells

Annals of the New York Academy of Sciences

Volumn 973, Issue , 2002, Pages 224-227

  Schlegel, J ^a   Durchschlag, G ^a   Piontek, G ^a   Grosu, A L ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Human glioblastoma cells; Protein kinase B dependent antiapoptotic pathway; PTEN deletions; Radioresistanee

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; APOPTOSIS INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; WORTMANNIN;

APOPTOSIS; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVATION; GLIOMA; HUMAN; HUMAN CELL; IRRADIATION; PROTEIN EXPRESSION; RADIOSENSITIVITY;

EID: 0036964788     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2002.tb04638.x     Document Type: Conference Paper

References (4)

1. SCHLEGEL, J., B. BUDDE, F. NEFF, et al. 2000. The Akt/protein kinase B-dependent anti-apoptotic pathway and the mitogen activated protein kinase cascade are alternatively activated in human glioblastoma multiforme. Cancer Lett. 158: 103-108.
2. HAAS-KOGAN, D., N. SHALEV, M. WONG, et al. 1998. Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. Curr. Biol. 8: 1195-1198.
3. KRAUS, A., M. GROSS, R. KNUELCHEL, et al. 2000. Aberrant p21 regulation in radioresistant primary glioblastoma cells bearing wild-type p53. J. Neurosurg. 93: 863-872.
4. WICK, W., F.B. FURNARI, U. NAUMANN, et al. 1999. PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis. Oncogene 18: 3936-3943.