Aberrant p21 regulation in radioresistant primary glioblastoma multiforme cells bearing wild-type p53

Journal of Neurosurgery

Volumn 93, Issue 5, 2000, Pages 863-872

  Kraus, Alison ^b   Gross, Markus W ^b   Knuechel, Ruth ^b   Munkel, Kristin ^b   Neff, Frauke ^b   Schlegel, Jürgen ^b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b NONE

Author keywords

Glioblastoma multiforme; p21; p53; Radioresistance

Indexed keywords

MESSENGER RNA; PROTEIN P21; PROTEIN P53;

APOPTOSIS; ARTICLE; CANCER GRADING; CANCER RADIOTHERAPY; CELL ACTIVITY; CELL CYCLE; CELL CYCLE G1 PHASE; CLINICAL ARTICLE; CONTROLLED STUDY; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IONIZING RADIATION; MITOSIS INHIBITION; MOLECULAR DYNAMICS; PRIORITY JOURNAL; RADIOSENSITIVITY; REGULATORY MECHANISM; TREATMENT FAILURE; TREATMENT PLANNING;

EID: 0034433688     PISSN: 00223085     EISSN: None     Source Type: Journal    
DOI: 10.3171/jns.2000.93.5.0863     Document Type: Article

References (34)

1. p53 protein accumulation and gene mutations in human glioma cell lines
2. p53 status has no prognostic significance in glioblastomas treated with radiotherapy
3. Amplification and overexpression of MDM2 in primary (de novo) glioblastomas
4. The p53 gene and its role in human brain tumors
5. Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts
6. Patient age, histologic features, and length of survival in patients with glioblastoma multiforme
7. Effects of ectopic overexpression of p21(WAF1/CIP1) on aneuploidy and the malignant phenotype of human brain tumor cells
8. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
9. WAF1/CIP1 is induced in p53-mediated Gl arrest and apoptosis
10. Analysis of cell cycle-related Ki-67 and p120 expression by flow cytometric BrdUrd-Hoechst/7AAD and immunolabeling technique
11. Overexpression of E2F-1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo
12. Ataxia telangiectasia mutated deficiency affects astrocyte growth but not radiosensitivity
13. Increased levels of p21WAF1/Cip1 in human brain tumors
14. Apoptosis. Its significance in cancer and cancer therapy
15. Multiple polymorphisms, but no mutations, in the WAF1/CIP 1 gene in human brain tumors
16. Expression of alternatively spliced mdm2 transcripts correlates with stabilized wild-type p53 protein in human glioblastoma cells
17. Regulation of DNA binding and transactivation in p53 by nuclear localization and phosphorylation
18. Cell cycle arrests and radiosensitivity of human tumour cell lines: Dependence on wild-type p53 for radiosensitivity
19. Genetic alterations associated with the evolution and progression of astrocytic brain tumors
20. The cyclin-dependent kinase inhibitor p21 (WAF1) is required for survival of differentiating neuroblastoma cells
21. Alterations of the TP53 gene in human gliomas
22. Overexpressed WAF1/Cip1 renders glioblastoma cells resistant to chemotherapy agents 1,3-bis(2-chloroethyl)-1-nitrosourea and cisplatin
23. Accumulation of wild type p53 protein in human astrocytomas
24. A p53-independent pathway for activation of WAF1/CIP1 expression following oxidative stress
25. Detection of complex genetic alterations in human glioblastoma multiforme using comparative genomic hybridization
26. The intrinsic radioresistance of glioblastoma-derived cell lines is associated with a failure of p53 to induce p21(BAX) expression
27. The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21 WAF1/CIP1
28. Analysis of the p53 gene and its expression in human glioblastoma cells
29. Current diagnostic concepts of astrocytic tumors
30. Association of epidermal growth factor receptor gene amplification with loss of chromosome 10 in human glioblastoma multiforme
31. Resistance to apoptosis conferred by Cdk inhibitors during myocyte differentiation
32. p53 and E2f-1 cooperate to mediate apoptosis