Synthesis and evaluation of a novel series of pyrrolizine derivatives as dual cyclooxygenase-1 and 5-lipoxygenase inhibitors

Archiv der Pharmazie

Volumn 330, Issue 9-10, 1997, Pages 307-312

  Laufer, Stefan ^a   Striegel, Hans Günter ^a   Neher, Karola ^a   Zechmeister, Pia ^a   Donat, Cornelia ^a   Stolingwa, Katrin ^a   Baur, Sibylle ^a   Tries, Susanne ^a   Kammermeier, Thomas ^a   Dannhardt, Gerd ^b   Kiefer, Werner ^b  

^a TEVA PHARMACEUTICALS   (Israel)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

5 lipoxygenase; 5 LOX; COX 1; Cyclooxygenase 1; ELISA; Enzyme linked immunosorbent assay; Heteroarylpyrrolizines; Non steroidal antiinflammatory drugs; NSAIDs

Indexed keywords

CALCIMYCIN; CYCLOOXYGENASE 1 INHIBITOR; DICLOFENAC; INDOMETACIN; LEUKOTRIENE B4; NONSTEROID ANTIINFLAMMATORY AGENT; NORDIHYDROGUAIARETIC ACID; PIROXICAM; PROSTAGLANDIN E2; PYRROLIZINE DERIVATIVE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG SCREENING; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SCREENING; STRUCTURE ACTIVITY RELATION; THROMBOCYTE;

ARACHIDONATE 5-LIPOXYGENASE; BLOOD PLATELETS; CYCLOOXYGENASE 1; CYCLOOXYGENASE INHIBITORS; FEMALE; HUMANS; ISOENZYMES; LIPOXYGENASE INHIBITORS; MALE; MEMBRANE PROTEINS; NEUTROPHILS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRROLES;

EID: 0030782456     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/ardp.19973300908     Document Type: Article

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