Evaluation of proliferative index and cell cycle protein expression in choroid plexus tumors in children

Acta Neuropathologica

Volumn 103, Issue 1, 2002, Pages 1-10

  Carlotti Jr , Carlos G ^a   Salhia, Badour ^a   Weitzman, Sheila ^a   Greenberg, Mark ^a   Dirks, Peter B ^a   Mason, Warren ^b   Becker, Lawrence E ^a   Rutka, James T ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cell cycle protein expression; Choroid plexus; Choroid plexus carcinoma; Proliferation

Indexed keywords

CARBOPLATIN; CELL CYCLE PROTEIN; CELL MARKER; CYCLIN E; ETOPOSIDE; IFOSFAMIDE; KI 67 ANTIGEN; MONOCLONAL ANTIBODY; PROTEIN P107; PROTEIN P53; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F;

ADOLESCENT; ARTICLE; BRAIN CANCER; BRAIN SURGERY; BRAIN VENTRICLE; CANCER SURVIVAL; CELL CYCLE; CELL PROLIFERATION; CHILD; CHOROID PLEXUS PAPILLOMA; CHOROID PLEXUS TUMOR; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DEATH; FEMALE; FOLLOW UP; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFANT; LABELING INDEX; MALE; MEDICAL ASSESSMENT; MEDICAL RECORD; PRIORITY JOURNAL; PROTEIN EXPRESSION; TIME; TREATMENT OUTCOME; TUMOR CELL;

ADOLESCENT; ANTIGENS, NUCLEAR; CELL CYCLE PROTEINS; CELL DIVISION; CHILD; CHILD, PRESCHOOL; CHOROID PLEXUS NEOPLASMS; CYCLIN E; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; KI-67 ANTIGEN; MALE; NUCLEAR PROTEINS; PAPILLOMA, CHOROID PLEXUS; RETINOBLASTOMA PROTEIN; RETINOBLASTOMA-LIKE PROTEIN P107; SURVIVAL ANALYSIS; SYNAPTOPHYSIN; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0036938657     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010100419     Document Type: Article

References (53)

1. Adams PD, Li X, Sellers W. R, Baker KB, Leng X, Harper JW, Taya Y, Kaelin WG Jr (1999) Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes. Mol Cell Biol 19:1068-1080
2. Aguzzi A, Weber T, Paulus W (1997) Choroid plexus tumours. In: Kleihues P, Cavenee WK (eds) Pathology and genetics of tumors of the nervous system, 1st edn. International Agency for Research on Cancer, Lyon, pp 16-24
3. Ang LC, Taylor A. R, Bergin D, Kaufmann JC (1990) An immunohistochemical study of papillary tumors in the central nervous system. Cancer 65:2712-2719
4. Berger C, Thiesse P, Lellouch-Tubiana A, Kalifa C, Pierre-Kahn A, Bouffet E (1998) Choroid plexus carcinomas in childhood: clinical features and prognostic factors. Neurosurgery 42:470-475
5. Bergsagel DJ, Finegold MJ, Butel JS, Kupsky WJ, Garcea RL (1992) DNA sequences similar to those of simian virus 40 in ependymomas and choroid plexus tumors of childhood. N Engl J Med 326:988-993
6. Coffin CM, Wick MR, Braun JT, Dehner LP (1986) Choroid plexus neoplasms. Clinicopathologic and immunohistochemical studies. Am J Surg Pathol 10:394-404
7. Cruz-Sanchez FF, Rossi ML, Hughes JT, Coakham HB, Figols J, Eynaud PM (1989) Choroid plexus papillomas: an immunohistological study of 16 cases. Histopathology 15:61-69
8. Danks RA, Orian JM, Gonzales MF, Tan SS, Alexander B, Mikoshiba K, Kaye AH (1995) Transformation of astrocytes in transgenic mice expressing SV40 T antigen under the transcriptional control of the glial fibrillary acidic protein promoter. Cancer Res 55:4302-4310
9. Dirks PB, Rutka JT (1997) Current concepts in neuro-oncology. The cell cycle - a review. Neurosurgery 40:1000-1015
10. Dirks PB, Murakami M, Hubbard S. L, Rutka JT (1997) Cyclins and cyclin-dependent kinase expression in human astrocytoma cell lines. J Neuropathol Exp Neurol 56:291-300
11. Dirks PB, Patel K, Hubbard SL, Ackerley C, Hamel PA, Rutka JT (1997) Retinoic acid and cyclin-dependent kinase inhibitors synergistically alter proliferation and morphology of U343 astrocytoma cells. Oncogene 15:2037-2048
12. Dirks PB, Rutka JT, Hubbard SL, Mondal S, Hamel PA (1998) The E2F-family proteins induce distinct cell cycle regulatory factors in p16-arrested, U343 astrocytoma cells. Oncogene 17: 867-876
13. Dyson N (1998) The regulation of E2F by pRB-family proteins. Genes Dev 12:2245-2262
14. Felix CA, Slavc I, Dunn M, Strauss EA, Phillips PC, Rorke LB, Sutton L, Bunin GR, Biegel JA (1995) p53 gene mutations in pediatric brain tumors. Med Pediatr Oncol 25:431-436
15. Giaccia AJ, Kastan MB (1998) The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev 12:2973-2983
16. Gianella-Borradori A, Zeltzer PM, Bodey B, Nelson M, Britton H, Marlin A (1992) Choroid plexus tumors in childhood. Response to chemotherapy, and immunophenotypic profile using a panel of monoclonal antibodies. Cancer 69:809-816
17. Greenberg ML (1999) Chemotherapy of choroid plexus carcinoma. Childs Nerv Syst 15:571-577
18. Gupta N, Rutka JT (2000) Molecular neuro-oncology. In: Bernstein M, Berger MS (eds) Neuro-oncology: the essentials. vol 1. Thieme, New York, pp 30-41
19. Hall M, Peters G (1996) Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer. Adv Cancer Res 68:67-108
20. Helin K (1998) Regulation of cell proliferation by the E2F transcription factors. Curr Opin Genet Dev 8:28-35
21. Herbert J, Cavallaro T, Dwork AJ (1990) A marker for primary choroid plexus neoplasms. Am J Pathol 136:1317-1325
22. Hsieh JK, Chan FS, O'Connor DJ, Mittnacht S, Zhong S, Lu X (1999) RB regulates the stability and the apoptotic function of p53 via MDM2. Mol Cell 3:181-193
23. Hsu DW, Louis DN, Efird JT, Hedley-Whyte ET (1997) Use of MIB-1 (Ki-67) immunoreactivity in differentiating grade II and grade III gliomas. J Neuropathol Exp Neurol 56:857-865
24. Jay V, Ho M, Chan F, Malkin D (1996) p53 expression in choroid plexus neoplasms. An immunohistochemical study. Arch Pathol Lab Med 120:1061-1065
25. Kato T, Fujita M, Sawamura Y, Tada M, Abe H, Nagashima K, Nakamura N (1996) Clinicopathological study of choroid plexus tumors: immunohistochemical features and evaluation of proliferative potential by PCNA and Ki-67 immunostaining. Noshuyo Byori 13:99-105
26. Kepes JJ, Collins J (1999) Choroid plexus epithelium (normal and neoplastic) expresses synaptophysin. A potentially useful aid in differentiating carcinoma of the choroid plexus from metastatic papillary carcinomas. J Neuropathol Exp Neurol 58: 398-401
27. Knudsen ES, Buckmaster C, Chen TT, Feramisco JR, Wang JY (1998) Inhibition of DNA synthesis by RB: effects on G1/S transition and S-phase progression. Genes Dev 12:2278-2292
28. Kouno M, Kumanishi T, Washiyama K, Sekiguchi K, Saito T, Tanaka R (1988) An immunohistochemical study of cytokeratin and glial fibrillary acidic protein in choroid plexus papilloma. Acta Neuropathol 75:317-320
29. Marks JR, Lin J, Hinds P, Miller D, Levine AJ (1989) Cellular gene expression in papillomas of the choroid plexus from transgenic mice that express the simian virus 40 large T antigen. J Virol 63:790-797
30. Miettinen M, Clark R, Virtanen I (1986) Intermediate filament proteins in choroid plexus and ependyma and their tumors. Am J Pathol 123:231-240
31. Mittnacht S (1998) Control of pRB phosphorylation. Curr Opin Genet Dev 8:21-27
32. Muthuphei MN (1995) Divergent differentiation in choroid plexus papilloma. An immunohistochemical study of five cases. Cent Afr J Med 41:103-104
33. Nakamura M, Yonekawa Y, Kleihues P, Ohgaki H (2001) Promoter hypermethylation of the RB1 gene in glioblastomas. Lab Invest 81:77-82
34. Newbould MJ, Kelsey AM, Arango JC, Ironside JW, Birch J (1995) The choroid plexus carcinomas of childhood: histopathology, immunocytochemistry and clinicopathological correlations. Histopathology 26:137-143
35. Ohgaki H, Eibl RH, Schwab M, Reichel MB, Mariani L, Gehring M, Petersen I, Holl T, Wiestler OD, Kleihues P (1993) Mutations of the p53 tumor suppressor gene in neoplasms of the human nervous system. Mol Carcinog 8:74-80
36. Pan H, Yin C, Dyson NJ, Harlow E, Yamasaki L, Van Dyke T (1998) Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors. Mol Cell 2: 283-292
37. Park WY, Kim JI, Shim EH, Lee WH, Kim SH, Seo JW, Jang JJ, Seo JS (1996) Development of thymic carcinoma in transgenic mice expressing SV40 T antigen. Cancer Lett 107:293-300
38. Paulus W, Brandner S (1999) Synaptophysin in choroid plexus epithelial cells: no useful aid in differential diagnosis. J Neuropathol Exp Neurol 58:1111-1112
39. Paulus W, Janisch W (1990) Clinicopathologic correlations in epithelial choroid plexus neoplasms: a study of 52 cases. Acta Neuropathol 80:635-641
40. Pencalet P, Sainte-Rose C, Lellouch-Tubiana A, Kalifa C, Brunelle F, Sgouros S, Meyer P, Cinalli G, Zerah M, Pierre-Kahn A, Renier D (1998) Papillomas and carcinomas of the choroid plexus in children. J Neurosurg 88:521-528
41. Prives C (1998) Signaling to p53: breaking the MDM2-p53 circuit. Cell 95:5-8
42. Rubinstein LJ, Brucher JM (1981) Focal ependymal differentiation in choroid plexus papillomas. An immunoperoxidase study. Acta Neuropathol 53:29-33
43. Saenz Robles MT, Symonds H, Chen J, Van Dyke T (1994) Induction versus progression of brain tumor development: differential functions for the pRB- and p53-targeting domains of simian virus 40 T antigen. Mol Cell Biol 14:2686-2698
44. Sherr CJ (1998) Tumor surveillance via the ARF-p53 pathway. Genes Dev 12:2984-2991
45. Sidle A, Palaty C, Dirks P, Wiggan O, Gill RM, Wong AK, Hamel PA (1996) Activity of the retinoblastoma family proteins, pRB, p107, and p130, during cellular proliferation and differentiation. Crit Rev Biochem Mol Biol 31:237-271
46. Souweidane MM, Johnson JH Jr, Lis E (1999) Volumetric reduction of a choroid plexus carcinoma using preoperative chemotherapy. J Neurooncol 43:167-171
47. St. Clair SK, Humphreys RP, Pillay PK, Hoffman HJ, Blaser SI, Becker LE (1991) Current management of choroid plexus carcinoma in children. Pediatr Neurosurg 17:225-233
48. Tsugu A, Dirks P, Jung S, Kurimoto M, Jay V, Murakami M, Rutka JT (1997) Cell cycle control in pediatric neuro-oncology. Pediatric Neurosurg (in press)
49. Vital A, Bringuier PP, Huang H, San Galli F, Rivel J, Ansoborlo S, Cazauran JM, Taillandier L, Kleihues P, Ohgaki H (1998) Astrocytomas and choroid plexus tumors in two families with identical p53 germline mutations. J Neuropathol Exp Neurol 57:1061-1069
50. Vogelstein B, Kinzler KW (1992) p53 function and dysfunction. Cell 70:523-526
51. Xiangming C, Natsugoe S, Takao S, Hokita S, Tanabe G, Baba M, Kuroshima K, Aikou T (2000) The cooperative role of p27 with cyclin E in the prognosis of advanced gastric carcinoma. Cancer 89:1214-1219
52. Yasui W, Naka K, Suzuki T, Fujimoto J, Hayashi K, Matsutani N, Yokozaki H, Tahara E (1999) Expression of p27Kip1, cyclin E, and E2F-1 in primary and metastatic tumors of gastric carcinoma. Oncol Rep 6:983-987
53. Zhang SY, Liu SC, Al-Saleem LF, Holloran D, Babb J, Guo X, Klein-Szanto AJ (2000) E2F-1: a proliferative marker of breast neoplasia. Cancer Epidemiol Biomarkers Prev 9:395-401