Impact of physiologically based pharmacokinetic modeling on benchmark dose calculations for TCDD-induced biochemical responses

Regulatory Toxicology and Pharmacology

Volumn 36, Issue 3, 2002, Pages 287-296

  Kim, Amy H ^a,b   Kohn, Michael C ^b   Portier, Christopher J ^b   Walker, Nigel J ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Benchmark dose; Biochemical responses; PBPK modeling; Risk assessment; TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; MESSENGER RNA;

ABSORPTION; ANIMAL EXPERIMENT; ARTICLE; BODY BURDEN; CLINICAL CHEMISTRY; CONTROLLED STUDY; DOSE CALCULATION; FEMALE; INTERMETHOD COMPARISON; MODEL; NONHUMAN; PRIORITY JOURNAL; QUALITY CONTROL; RAT; RISK ASSESSMENT; STEADY STATE;

EID: 0036929325     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1006/rtph.2002.1590     Document Type: Article

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