Distinct sites on ABCA1 control distinct steps required for cellular release of phospholipids

Journal of Lipid Research

Volumn 43, Issue 12, 2002, Pages 2077-2086

  Rigot, Véronique ^a   Hamon, Yannick ^a   Chambenoit, Olivier ^a   Alibert, Mélanie ^a   Duverger, Nicolas ^b   Chimini, Giovanna ^a  

^a CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

^b SANOFI   (France)

Author keywords

ABC transporter; Lipid flipping; Membrane topology; Structure function map; Tangier disease

Indexed keywords

ABC TRANSPORTER; APOLIPOPROTEIN; APOLIPOPROTEIN A1; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; MEMBRANE LIPID; PHOSPHOLIPID; ABC TRANSPORTER A1;

ARTICLE; CELL SECRETION; CELL SURFACE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MEMBRANE BINDING; MEMBRANE STRUCTURE; MUTATION; PHOSPHOLIPID TRANSFER; PRIORITY JOURNAL; PROTEIN FUNCTION; STRUCTURE ACTIVITY RELATION; TANGIER DISEASE; BINDING SITE; CELL MEMBRANE; GENETICS; HELA CELL; IMMUNOBLOTTING; METABOLISM; MISSENSE MUTATION; SECRETION;

ATP-BINDING CASSETTE TRANSPORTERS; BINDING SITES; CELL MEMBRANE; HELA CELLS; HUMANS; IMMUNOBLOTTING; MUTATION, MISSENSE; PHOSPHOLIPIDS; STRUCTURE-ACTIVITY RELATIONSHIP; TANGIER DISEASE;

EID: 0036906543     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1194/jlr.M200279-JLR200     Document Type: Article

References (36)

1. Tall, A. R., and N. Wang. 2000. Tangier disease as a test of the reverse cholesterol transport hypothesis. J. Clin. Invest. 106: 1205-1207.
2. Fielding, P. E., K. Nagao, H. Hakamata, G. Chimini, and C. J. Fielding. 2000. A two-step mechanism for free cholesterol and phospholipid efflux from human vascular cells to apolipoprotein A-1. Biochemistry. 39: 14113-14120.
3. Bodzioch, M., E. Orso, J. Klucken, T. Langmann, A. Böttcher, W. Diederich, W. Drobnik, S. Barlage, C. Büchler, M. Porsch-Özcürümez, W. E. Kaminski, H. W. Hahmann, K. Oette, G. Rothe, C. Aslanidis, K. J. Lackner, and G. Schmitz. 1999. The gene encoding ATP-binding casette transporter 1 is mutated in Tangier disease. Nature Genet. 22: 347-351.
4. Brooks-Wilson, A., M. Marcil, S. M. Clee, L. H. Zhang, K. Roomp, M. van Dam, B. F. Yu, C. Brewer, J. A. Collins, H. O. Molhuizen, O. Loubser, B. F. Oueleue, K. Fichter, K. J. Ashbourne-Excoffon, C. W. Sensen, S. Scherer, S. Mott, M. Denis, D. Martindale, J. Frohlich, K. Morgan, B. Koop, S. Pimstone, J. J. Kastelein, J. Genest, Jr., and M. R. Hayden. 1999. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Nature Genet. 22: 336-345
5. Lawn, R. M., D. P. Wade, M. R. Garvin, X. Wang, K. Schwartz, J. G. Porter, J. J. Seilhamer, A. M. Vaughan, and J. F. Oram. 1999. The tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway. J. Clin. Invest. 104: R25-31.
6. Rust, S., M. Rosier, H. Funke, J. Real, Z. Amoura. J. C. Piette, J. F. Deleuze, H. B. Brewer, N. Duverger, P. Denefle, and G. Assmann. 1999. Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter I. Nature Genet. 22: 352-355
7. Christiansen-Weber, T. A., J. R. Voland, Y. Wu, K. Ngo, B. L. Roland, S. Nguyen, P. A. Peterson, and W. P. Fung-Leung. 2000. Functional loss of ABCA1 in mice causes severe placental malformation, aberrant lipid distribution, and kidney glomerulonephritis as well as high-density lipoprotein cholesterol deficiency. Am. J. Pathol. 157: 1017-1029.
8. McNalsh, J., R. J. Aiello, D. Guyot, T. Tuff, C. Gabel, C. Aldinger, K. L. Hoppe, M. L. Roach, I. J. Royer, J. de Wet, C. Broccardo, G. Chimini, and O. L. Francone. 2000. High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1. Proc. Natl. Acad. Sci. USA. 97: 4245-4250.
9. Hamon, Y., C. Broccado, O. Chambenoit, M. F. Luciani, F. Toli, S. Chaslin, J. M. Freyssinet, F. Devaux, J. Neish, D. Marguet, and G. Chimini. 2000. ABC1 promotes engulfment of apoplotic cells and transbilayer redistribution of phosphatidylserine. Nat. Cell Biol. 2: 399-406.
10. Assmann, G., A. von Eckardstein, and H. B. Brewer. 2001. Familial analphalipoproteinemia: Tangier disease. In The Metabolic Basis of Inherited Disease. C. R. Scriver, A. L. Beaudel, W. S. Sly, D. Valle, editor. McGraw-Hill, New York. 2937-2960.
11. Remaley, A. T., U. K. Schumacher, J. A. Stonik, B. D. Farsi, H. Nazih, and H. B. Brewer, Jr. 1997. Decreased reverse cholesterol transport from Tangier disease fibroblast. Acceptor specificity and effect of brefeldin on lipid efflux. Arterioscler. Thromb. Vasc. Biol. 17: 1813-1821.
12. Chambenoit, O., Y. Hamon, D. Marguet, H. Rigneault, M. Rosseneu, and G. Chimini. 2001. Specific docking of apolipoprotein A-I at the cell surface requires a functional ABCA1 transporter. J. Biol. Chem. 276: 9955-9960.
13. Wang, N., D. L. Silver, C. Thiele, and A. R. Tall. 2001. ABCA1 functions as a cholesterol efflux regulatory protein. J. Biol. Chem. 276: 23742-23747.
14. Vallejo, A. N. 1995. Mutagenesis and synthesis of novel recombinant genes using PCR. In PCR Primers. C. W. Dieffenbach, editor. Cold Springs Harbor Laboratory Press, New York. 603-625.
15. Bligh, E. G. and W. J. Dyer., 1959. A rapid method of total lipid extraction and purification. Can. J. Biochem. Phys. 37: 911-917.
16. Dean, M., Y. Hamon, and G. Chimini. 2001. The human ATP-binding cassette (ABC) transporter superfamily. J. Lipid Res. tramsporter superfamily. J. Lipid Roi. 42: 1007-1017.
17. Wang, N., D. L. Silver, P. Costet, and A. R. Tall. 2000. Specific binding of ApoA-1, enhanced cholesterol efflux, and altered plasma membrane morphology in cells expressing ABC1. J. Biol. Chem. 275: 33053-33058.
18. Tanaka, A. R., Y. Ikeda, S. Abe-Dohmae, R. Arakawa, K. Sadanami, A, Kidera, S. Nakagawa, T. Nagase, R. Aoki, N. Kioka, T. Amachi, S. Yokoyama, and K. Ueda. 2001. Human ABCA1 comains a large amino-terminal extracellular domain homologous to an epitope of Sjogren's syndrome. Biochem. Biophys. Res. Commun. 283: 1019-1025.
19. Fitzgerald, M. L., A. J. Mendez, K. J. Moore, L. P. Andersson, H. A. Panjeton, and M. W. Freeman. 2001. ABCA1 contains an N-terminal signal-anchor sequence that translocates the protein's first hydrophilic domain to the exoplasmic space. J. Biol. Chem. 276: 15137-15145.
20. Glee, S. M., J. J. Kastelein, M. van Dam, M. Marcil, K. Roomp, K. Y. Zwarts, J. A. Collins, R. Roelants, N. Tamasawa, T. Suda, R. Ceska, B. Boucher, C. Rondeau, G. DeSouich, A. Brooks-Wilson, H. O. Molhuizen, J. Frohlich, J. Genest, Jr., and M. R. Hayden. 2000. Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes. J. Clin. Invest. 106: 1263-1270.
21. Luciani, M. F., F. Denizot, S. Savary, M. G. Mattei, and G. Chimini. 1994. Cloning of two novel ABC transporters mapping on human chromosome 9. Genomics. 21: 150-159.
22. Fitzgerald, M. L., A. L. Morris, J. S. Rhee, L. P. Andersson, A. J. Mendez, and M. W. Freeman. 2002. Naturally occuring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-1. J. Biol. Chem. 277: 33178-33187.
23. Bungert, S., L. L. Molday, and R. S. Molday. 2001. Membrane topology of the ATP binding cassette transporter ABCR and its relationship to ABC1 and related ABCA transporters. J. Biol. Chem. 276: 23539-23546.
24. Illing, M., L. L. Molday, and R. S. Molday. 1997. The 220-kDa rim protein of retinal rod outer segment is a member of the ABC transporter superfamily. J. Biol. Chem. 272: 10303-10310.
25. Wine, J.J. 1995. Cystic fibrosis: How do CFTR mutations cause cystic fibrosis? Curr. Biol. 5: 1357-1359.
26. Smith, J. D., C. Waelde, A. Horwitz, and P. Zheng. 2002. Evaluation of the role of phosphatidylserine translocase activity in ABCA1 mediated lipid efflux. J. Biol. Chem. 13: 13.
27. Tall, A. R., N. Wang, and P. Mucksavage. 2001. Is it time to modify the reverse cholesterol transport model? J. Clin. Invest. 108: 1273-1275.
28. Haghpassand, M., P. A. Bourassa, O. L. Francone, and R. J. Aiello. 2001. Monocyte/macrophage expression of ABCA1 has minimal contribution to plasma HDL levels. J. Clin. Invest. 108: 1315-1320.
29. Wellington, C. L., E. K. Walker, A. Suarez, A. Kwok, N. Bissada, R. Singaraja, Y. Z. Yang, L. H. Zhang, E. James, J. E. Wilson, O. Francone, B. M. McManus, and M. R. Hayden. 2002. ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation. Lab. Invest. 82: 273-283.
30. Luciani, M. F., and G. Chimini. 1996. The ATP binding cassette transporter ABC1, is required for the engulfment of corpses generated by apoptoic cell death. EMBO J. 15: 226-235.
31. Oram, J. F., R. M. Lawn, M. R. Garvin, and D. P. Wade. 2000. ABCAI is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages. J. Biol. Chem. 275: 34508-34511.
32. Bertolini, S., L. Pisciotta, M. Seri, R. Gusano, A. Cantafora, L. Calabresi, G. Franceschini, R. Ravazzolo, and S. Calandra. 2001. A point mutation in ABC1 gene in a patient with severe premature coronary heart disease and mild clinical phenotype of Tangier disease. Atherosclerosis. 154: 599-605.
33. Clee, S. M., A. H. Zwindermann, J. C. Engert, K. Y. Zwarts, H. O. F. Molhuizen, K. Roomp, J. W. Jukema, M. van Wijland, M. van Dam, T. J. Hudson, A. Brooks-Wilson, J. Genest, Jr., J. J. P. Kastelein, and M. R. Hayden. 2001. Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease. Circulation. 103: 1198-1205.
34. Wang, J., J. R. Burnett, S. Near, K. Young, B. Zinman, A. J. Hanley, P. W. Connelly, S. B. Harris, and R. A. Hegele. 2000. Common and rare ABCA1 variants affecting plasma HDL cholesterol. Arterioscler. Thromb. Vasc. Biol. 20: 1983-1989.
35. Attie, A. D., J. P. Kastelein, and M. R. Hayden. 2001. Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis. J. Lipid Res. 42: 1717-1726.
36. van Dam, M. J., E. de Groot, S. M. Clee, G. K. Hovingh, R. Roelants, A. Brooks-Wilson, A. H. Zwinderman, A. J. Smit, A. H. Smelt, A. K., Groen, M. R. Hayden, and J. J. Kzstelein. 2002. Association between increased arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux: An observational study. Lancet. 359: 37-42.