ANTINEOPLASTIC ACTIVITY;
BLAST CELL CRISIS;
CANCER CHEMOTHERAPY;
CANCER GENETICS;
CHRONIC MYELOID LEUKEMIA;
COLORECTAL CANCER;
DIGESTIVE SYSTEM CANCER;
DRUG DEPENDENCE;
DRUG EFFICACY;
DRUG MECHANISM;
EDITORIAL;
GENE MUTATION;
GENE TARGETING;
GENETIC SCREENING;
HEAD AND NECK CANCER;
HUMAN;
LUNG NON SMALL CELL CANCER;
MELANOMA;
NONHUMAN;
ONCOGENE;
PROSTATE CANCER;
SIDE EFFECT;
TUMOR CELL;
DRUG COMBINATION;
DRUG EFFECT;
GENE THERAPY;
GENETICS;
GENOME;
NEOPLASM;
SIGNAL TRANSDUCTION;
ANTIBODIES, MONOCLONAL;
ANTINEOPLASTIC AGENTS;
DRUG THERAPY, COMBINATION;
GENE THERAPY;
GENOME, HUMAN;
HUMANS;
NEOPLASMS;
ONCOGENES;
PIPERAZINES;
PYRIMIDINES;
QUINAZOLINES;
SIGNAL TRANSDUCTION;
Linking molecular therapeutics to molecular diagnostics: Inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo
Mills GB, Lu Y, Kohn EC. Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo. Proc. Natl Acad. Sci. USA 98, 10031-10033 (2001).
Unravelling the complexities of the Raf/MAPK pathway for pharmacological intervention
Herrera R, Sebolt-Leopold JS. Unravelling the complexities of the Raf/MAPK pathway for pharmacological intervention. Trends Mol. Med. 8, S27-S31 (2002).
Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino, 17-demethoxy geldanamycin results in cytostasis and apoptosis
Hostein I, Robertson D, DiStefano F et al. Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino, 17-demethoxy geldanamycin results in cytostasis and apoptosis. Cancer Res. 61, 4003-4009 (2001).
A Phase III clinical trail of ZD1839 ('Iressa') in combination with gemacitabine and cisplatin in chemotherapy-naive patients with advanced non-small cell lung cancer (INTACT I)
(Abstract 4O)
Giaccone G Johnson DH, Manegold C et al. A Phase III clinical trail of ZD1839 ('Iressa') in combination with gemacitabine and cisplatin in chemotherapy-naive patients with advanced non-small cell lung cancer (INTACT I). Ann. Oncol. 13(Suppl. 5) 2 (2002) (Abstract 4O).
ZD1839 (Iressa) in combination with paclitaxel & carboplatin in chemotherapy-niave patients with advanced non-small cell lung cancer (NSCLC): Results from a Phase III trail (INTACT 2)
(Abstract 468O)
Johnson DH, Herbst R, Giaccone G et al. ZD1839 (Iressa) in combination with paclitaxel & carboplatin in chemotherapy-niave patients with advanced non-small cell lung cancer (NSCLC): results from a Phase III trail (INTACT 2). Ann. Oncol. 13(Suppl. 5) 127 (2002) (Abstract 468O).
(2002)Ann. Oncol., vol.13, Issue.SUPPL. 5, pp. 127