New insights and new issues in developmental neurotoxicology

NeuroToxicology

Volumn 23, Issue 6, 2002, Pages 659-668

  Olney, John W ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anesthetics; Apoptosis; Barbiturates; Benzodiazepines; Ethanol; GABAA receptors; Ketamine; NMDA receptors; Phencyclidine; Synaptogenesis

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; ALCOHOL; ANESTHETIC AGENT; ANTICONVULSIVE AGENT; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE DERIVATIVE; GLUTAMATE RECEPTOR; KETAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NITROUS OXIDE; PHENCYCLIDINE; SEDATIVE AGENT;

APOPTOSIS; BRAIN GROWTH; CELL ACTIVITY; CENTRAL NERVOUS SYSTEM; COGNITION; CONFERENCE PAPER; DISEASE ASSOCIATION; FETAL ALCOHOL SYNDROME; GESTATIONAL AGE; GROWTH ACCELERATION; NERVE CELL; NERVE DEGENERATION; NEUROTOXICOLOGY; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; SYNAPTIC TRANSMISSION; SYNAPTOGENESIS;

APOPTOSIS; CELL DEATH; NEURODEGENERATIVE DISEASES; NEUROTOXICITY SYNDROMES; SYNAPSES;

CAVIA PORCELLUS; SUS SCROFA;

EID: 0036902343     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-813X(01)00092-4     Document Type: Conference Paper

References (68)

1. Ankarkona M, Zhivotovsky B, Holmstrom T. Lamin and β-tubulin fragmentation precedes chromatin degradation in glutamate-induced neuronal apoptosis. Neuroreport 1996;7:2659-64.
2. Barr HM, Streissguth AP. Identifying maternal self-reported alcohol use associated with fetal alcohol spectrum disorders. Alcohol Clin Exp Res 2001;25:283-7.
3. Bittigau P, Sifringer M, Pohl D, Stadthaus D, Ishimaru M, Shimizu H, Ikeda M, Lang D, Speer A, Olney JW, Ikonomidou C. Apoptotic neurodegeneration following trauma is markedly enhanced in the immature brain. Ann Neurol 1999;45(6):724-35.
4. Bittigau P, Genz K, Bosch-Hörster F, Vockler J, Dikranian K, Tenkova T, Olney JW, Ikonomidou C. Barbiturates and benzodiazepines cause apoptotic neurodegeneration in the developing rat brain. Soc Neurosci Abstr 1999;25:551.
5. Bittigau P, Genz K, Engelbrechten S, Hoerster F, Dikranian K, Olney JW, Ikonomidou C. Anti-epileptics which enhance GABAergic inhibition cause neuronal apoptosis in the developing CNS. Soc Neurosci Abstr 2000;26:323.
6. Bonfoco E, Krainc D, Ankarcrona M, Lipton SA. Apoptosis and necrosis: Two distinct events induced, respectively by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc Natl Acad Sci USA 1995;92:7162-6.
7. Charriaut-Marlangue C, Ben-Ari Y. A cautionary note on the use of the TUNEL stain to determine apoptosis. Neuroreport 1995;7:61-4.
8. Choi DW. Excitotoxic cell death. J Neurobiol 1992;23:1261-76.
9. Clarren SK, Alvord AC, Sumi SM. Brain malformations related to prenatal exposure to ethanol. J Pediatr 1978;92:64-7.
10. Collins RJ, Harmon BV, Gobé GC, Kerr JFR. Internucleosomal DNA cleavage should not be the sole criterion for identifying apoptosis. Int J Radiat Biol 1992;61:451-3.
11. Corso TD, Sesma MA, Tenkova TI, Der TC, Wozniak DF, Farber NB, Olney JW. Multifocal brain damage induced by phencyclidine is augmented by pilocarpine. Brain Res 1997;752:1-14.
12. Dessens AB, Cohen-Kettenis PT, Mellenbergh GJ. Association of prenatal phenobarbital and phenytoin exposure with small head size and with learning problems. Acta Paediatr 2000;89:533-41.
13. Dikranian K, Tenkova T, Ikonomidou C, Olney JW. Histological characterization of apoptotic neurodegeneration induced in the developing rodent brain by barbiturates and benzodiazepines. Soc Neurosci Abstr 1999;25:1777.
14. Dikranian K, Ishimaru MJ, Tenkova T, Labruyere J, Qin YQ, Ikonomidou C, Olney JW. Apoptosis in the in vivo mammalian forebrain. Neurobiol Dis 2001;8:359-79.
15. Dobbing J, Sands J. The brain growth spurt in various mammalian species. Early Human Dev 1979;3:79-84.
16. Famy C, Streissguth AP, Unis AS. Mental illness in adults with fetal alcohol syndrome or fetal alcohol effects. Am J Psych 1998;155:552-4.
17. Farber NB, Wozniak DF, Price MT, Labruyere J, Huss J, St. Peter H, Olney JW. Age-specific neurotoxicity in the rat associated with NMDA receptor blockade: Potential relevance to schizophrenia. Biol Psychiatr 1995;38(12):788-96.
18. A receptors blocks neurotoxicity in the adult brain, but augments neurotoxicity in the developing brain. Soc Neurosci Abstr 1999;25:551.
19. Ferrer I, Martin F, Serrano T, Reiriz J, Perez-Navarro E, Alberch J, Macaya A, Planas AM. Both apoptosis and necrosis occur following intrastriatal administration of excitotoxins. Acta Neuropathol 1995;90:504-10.
20. Filipkowski RK, Hetman M, Kaminska B, Kaczmarek L. DNA fragmentation in rat brain after intraperitoneal administration of kainate. Neuroreport 1994;5:1538-40.
21. Fix AS, Long GG, Wozniak DF, Olney JW. Pathomorphologic effects of N-methyl-D-aspartate antagonists in the rat posterior cingulate/retrosplenial cerebral cortex. Drug Dev Res 1994;24:147-52.
22. Grasl-Kraupp B, Ruttkay-Nedecky B, Koudelka H, Bukowska K, Bursch W, Schulte-Hermann R. In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note. Hepatology 1995;21:1465-8.
23. Gwag BJ, Koh JY, Demaro JA, Ying HS, Jacquin M, Choi DW. Slowly triggered excitotoxicity occurs by necrosis in cortical cultures. Neuroscience 1997;77:393-401.
24. Harris RA, Proctor WR, McQuilkin SR, Klein RL, Mascia MP, Whatley V, Whiting PJ, Dunwiddie TV. Ethanol increases GABAA responses in cells stably transfected with receptor subunits. Alcohol Clin Exp Res 1995;19:226-32.
25. Hartman RE, Jevtovic-Todorovic V, Olney JW, Wozniak DF. Neonatal exposure to common anesthetics leads to spatial learning deficits in juvenile rats. Soc Neurosci Abstr 2001;27:398.
26. Hoffman PL, Rabe CS, Moses F, Tabakoff B. N-Methyl-D-aspartate receptors and ethanol: Inhibition of calcium flux and cyclic GMP production. J Neurochem 1989;52:1937-40.
27. Ikonomidou C, Price MT, Mosinger JL, Frierdich G, Labruyere J, Shahid Salles K, Olney JW. Hypobaric-ischemic conditions produce glutamate-like cytopathology in infant rat brain. J Neurosci 1989;9:1693-700.
28. Ikonomidou C, Qin Y, Labruyere J, Kirby C, Olney JW. Prevention of trauma-induced neurodegeneration in infant rat brain. Pediatr Res 1996;39:1020-7.
29. Ikonomidou C, Bosch F, Miksa M, Bittigau P, Vöckler J, Dikranian K, Tenkova T, Stevoska V, Turski L, Olney JW. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science 1999;283:70-4.
30. Ikonomidou C, Bittigau P, Ishimaru MJ, Wozniak DF, Koch C, Genz K, Price MT, Stefovska V, Hörster F, Tenkova T, Dikranian K, Olney JW. Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome. Science 2000;287:1056-60.
31. Ikonomidou C, Bittigau P, Ishimaru MJ, Wozniak DF, Koch C, Genz K, Price MT, Stefovska V, Hörster F, Tenkova T, Dikranian K, Olney JW. Drug-induced damage in the developing brain. Science 2000;288:976-7.
32. Ikonomidou C, Genz K, Engelbrechten Sv, Dikranian K, Olney JW, Bittigau P. Anti-epileptic drugs which block sodium channels cause neuronal apoptosis in the developing rat brain. Soc Neurosci Abstr 2000;26:323.
33. Ishimaru M, Fukamauchi F, Olney JW. Halothane prevents MK801 neurotoxicity in the rat cingulate cortex. Neurosci Lett 1995;193:1-4.
34. Ishimaru MJ, Ikonomidou C, Tenkova TI, Der TC, Dikranian K, Sesma MA, Olney JW. Distinguishing excitotoxic from apoptotic neurodegeneration in the developing rat brain. J Comp Neurol 1999;408:461-76.
35. Jevtovic-Todorovic V, Kirby CO, Olney JW. Isoflurane and propofol block neurotoxicity caused by MK801 in the rat posterior cingulate/retrosplenial cortex. J Cereb Blood Flow Metab 1997;17:168-74.
36. Jevtovic-Todorovic V, Todorovic SM, Mennerick S, Powell S, Dikranian K, Bensoff N, Zorumski CF, Olney JW. Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin. Nature Med 1998;4:460-3.
37. Jevtovic-Todorovic V, Wozniak DF, Benshoff N, Olney JW. Commonly used anesthesia protocol causes neuronal suicide in the immature rat brain. Soc Neurosci Abstr 2001;27:398.
38. Jones KL, Smith DW. Recognition of the fetal alcohol syndrome in early infancy. Lancet 1973;999-1001.
39. Jones KL, Smith DW. The fetal alcohol syndrome. Teratology 1975;12:1-10.
40. Jones KL, Smith DW, Ulleland CN, Streissguth AP. Pattern of malformation in offspring of chronic alcoholic mothers. Lancet 1973;1267-71.
41. Kerr JFR, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wideranging implications in tissue kinetics. Brit J Cancer 1972;26:239-57.
42. Lesort M, Esclaire F, Yardin C, Hugon J. NMDA induces apoptosis and necrosis in neuronal cultures. Increased APP immunoreactivity is linked to apoptotic cells. Neurosci Lett 1997;221:213-6.
43. Lipton SA, Rosenberg PA. Excitatory amino acids as a final common pathway for neurologic disorders. N Eng J Med 1994;330:613-22.
44. Lovinger DM, White G, Weight FF. Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science 1989;243:1721-4.
45. Mennerick S, Jevtovic-Todorovic V, Todorovic SM, Shen W, Olney JW, Zorumski CF. Effect of nitrous oxide on excitatory and inhibitory synaptic transmission in hippocampal cultures. J Neurosci 1998;18(23):9716-26.
46. Mennerick S, Zorumski CF. Neural activity and survival in the developing nervous system. Mol Neurobiol 2000;22(1-3):41-54.
47. Olney JW. Brain lesions, obesity and other disturbances in mice treated with monosodium glutamate. Science 1969;164:719-21.
48. Olney JW. Glutamate-induced neuronal necrosis in the infant mouse hypothalamus: An electron microscopic study. J Neuropathol Exp Neurol 1971;30:75-90.
49. Olney, JW. Toxic effects of Glu and related amino acids on the developing central nervous system. In: Nyhan WN, editor. Heritable Disorders of Amino Acid Metabolism. New York: Wiley, 1974. p. 501-12.
50. Olney JW. Neurotoxicity of excitatory amino acids. In: McGeer E, Olney JW, McGeer P, editors. Kainic Acid as a Tool in Neurobiology. New York: Raven, 1978. p. 95-121.
51. Olney JW. Excitatory amino acids and neuropsychiatric disorders. Biol Psychiatr 1989;26:505-25.
52. Olney JW, Ishimaru MJ. Excitotoxic cell death. In: Koliatsos VE, Ratan RR, editors. Cell Death and Diseases of the Nervous System. Totowa (NJ): Humana Press Inc., 1999. p. 197-219.
53. Olney JW, Ho OL, Rhee V. Cytotoxic effects of acidic and sulphur-containing amino acids on the infant mouse central nervous system. Exp Brain Res 1971;14:61-76.
54. Olney JW, Sharpe LG, Feigin RD. Glutamate-induced brain damage in infant primates. J Neuropathol Exp Neurol 1972;31:464-88.
55. Olney JW, Rhee V, Ho OL. Kainic acid: A powerful neurotoxic analogue of glutamate. Brain Res 1974;77:507-12.
56. Olney JW, Labruyere J, Price MT. Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science 1989;244:1360-2.
57. Olney JW, Labruyere J, Wang G, Wozniak DF, Price MT, Sesma MA. NMDA antagonist neurotoxicity: Mechanism and prevention. Science 1991;254:1515-8.
58. Olney JW, Price MT, Labruyere J, Tenkova T. Perinatal hypoxia/ischemia kills neurons directly by excitotoxic necrosis and indirectly by deafferentation apoptosis. Soc Neurosci Abstr 2000;26:1880.
59. Olney JW, Tenkova T, Dikranian K, Muglia LJ, Roth KA. Ethanol-induced caspase-3 activation in the in vivo developing mouse brain. Neurobiol Dis 2002, in press.
60. Pohl D, Bittigau P, Ishimaru MJ, Stadthaus D, Hubner C, Olney JW, Turski L, Ikonomidou C. Apoptotic cell death triggered by head injury in infant rats is potentiated by NMDA antagonists. Proc Natl Acad Sci USA 1999;96:2508-13.
61. Portera-Cailliau C, Price DL, Martin LJ. Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum. J Comp Neurol 1997;378:70-87.
62. Sloviter RS, Dean E, Neubort S. An electron microscopic analysis of adrenalectomy-induced hippocampal granule cell degeneration in the rat, apoptosis in the adult central nervous system. J Comp Neurol 1993;330:337-51.
63. Stratton K, Howe C, Battaglia FF, et al. Alcohol Syndrome: Diagnosis, Epidemiology, Prevention and Treatment. Washington (DC): National Academy Press, 1996.
64. Streissguth AP, O'Malley K. Neuropsychiatric implications and long-term consequences of fetal alcohol spectrum disorders. Semin Clin Neuropsych 2000;5:177-90.
65. Swayze VW, Johnson VP, Hanson JW, Piven J, Sato Y, Andreasen NC. Magnetic resonance imaging of brain anomalies in fetal alcohol syndrome. Pediatrics 1997;99:232-40.
66. Tenkova T, Muglia L, Dikranian K, Roth KA, Olney JW. Ethanol triggers a widespread pattern of caspase-3 activation and an identical pattern of apoptotic neurodegeneration in the developing mouse brain. Soc Neurosci Abstr 2001;27:450.
67. Van Lookeren Compagne M, Gill R. Ultrastructural morphological changes are not characteristic of apoptotic cell death following focal cerebral ischaemia in the rat. Neurosci Lett 1996;213:111-4.
68. Wyllie AH, Kerr JFR, Currie AR. Cell death: The significance of apoptosis. Int Rev Cytol 1980;68:251-306.