Sensitivity of HaCat keratinocytes to diabetogenic toxins

Biochemical Pharmacology

Volumn 63, Issue 2, 2002, Pages 171-178

  Harel, Avikam ^a,b   Bloch, Olga ^a,b   Vardi, Pnina ^b   Bloch, Konstantin ^b  

^a TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Alloxan; Apoptosis; Cytotoxicity; HaCat keratinocytes; Necrosis; Streptozotocin

Indexed keywords

3 AMINOBENZAMIDE; 3 METHYLGLUCOSE; ALLOXAN; ENZYME INHIBITOR; GLUCOSE TRANSPORTER; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; STREPTOZOCIN;

APOPTOSIS; ARTICLE; CELL DAMAGE; CELL DEATH; CELL IMMORTALIZATION; CELL LINE; CELL METABOLISM; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; DIABETES MELLITUS; DNA ALKYLATION; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVATION; GENOTOXICITY; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL;

ALLOXAN; ANALYSIS OF VARIANCE; APOPTOSIS; BENZAMIDES; CELL LINE; CELL SURVIVAL; ENZYME INHIBITORS; GUANOSINE; HUMANS; KERATINOCYTES; NECROSIS; NIACINAMIDE; POLY(ADP-RIBOSE) POLYMERASES; STREPTOZOCIN;

EID: 0037081753     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00847-4     Document Type: Article

References (32)

1. Maintenance of human skin in organ culture: Role for insulin-like growth factor-1 receptor and epidermal growth factor receptor
2. Statistical association between psoriasis and diabetes: Further results
3. In vitro dermal intoxication by bis(chloroethyl)sulfide. Effect on secondary epidermization
4. Failure to observe a relationship between bis-(beta-chloroethyl)sulfide-induced NAD depletion and cytotoxicity in the rat keratinocyte culture
5. Appearance of interleukin 1 alpha relates DNA interstrand cross-links and cytotoxicity in cultured human keratinocytes exposed to bis-(2-chloroethyl) sulfide
6. DNA damage, poly(ADP-ribosyl)ation and apoptotic cell death as a potential common pathway of cytotoxic drug action
7. Alkylation of DNA in rat tissues following administration of streptozotocin
8. Alloxan: History and mechanism of action
9. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line
10. Reconstruction of a human skin equivalent using a spontaneously transformed keratinocyte cell line HaCat
11. Skin lesions in diabetes mellitus: Prevalence and clinical correlations
12. Effect of auto-oxidized phospholipids on oxidative enzyme assays based on tetrazolium salt reduction
13. Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program
14. A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis
15. 2 as an intermediate
16. Protection by superoxide dismutase, catalase, and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis
17. Nicotinamide protects human beta cells against chemically-induced necrosis, but not against cytokine-induced apoptosis
18. STZ transport and cytotoxicity. Specific enhancement in GLUT-2-expressing cells
19. Different signaling pathways mediate insulin and IGF-1 induced proliferation of cultured keratinocytes
20. Streptozotocin and alloxan-based selection improves toxin resistance of insulin-producing RINm cells
21. Site-specific DNA methylation and apoptosis: Induction by diabetogenic streptozotocin
22. Characterization of the oxidative stress initiated in cultured human keratinocytes by treatment with peroxides
23. Insulinoma cells in culture show pronounced sensitivity to alloxan-induced oxidative stress
24. Acute effects of near ultraviolet and visible light on the cutaneous antioxidant defense system
25. Metal-mediated DNA damage induced by diabetogenic alloxan in the presence of NADH
26. β-Cell maturation leads to in vitro sensitivity to cytotoxins
27. Tissue distribution of streptozotocin (NSC-85998)
28. Prediction of stability in pharmaceutical preparations. Part VII. The solution degradation of the antibiotic streptozotocin
29. Streptozotocin: A review of its pharmacology, efficacy, and toxicity
30. Degradation products of streptozotocin do not induce hyperglycemia in rats
31. Pancreatic islet cell tumors produced by the combined action of streptozotocin and nicotinamide
32. Effects of nicotinamide on biochemical changes and microblistering induced by sulfur mustard in human skin organ cultures