Mutations conferring ganciclovir resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis

Journal of Infectious Diseases

Volumn 183, Issue 2, 2001, Pages 333-337

  Jabs, Douglas A ^a,b   Martin, Barbara K ^b   Forman, Michael S ^c   Dunn, J P ^a   Davis, Janet L ^d   Weinberg, David V ^e   Biron, Karen K ^f   Baldanti, Fausto ^g  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c DEPARTMENT OF PATHOLOGY   (United States)

^d UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^e NORTHWESTERN UNIVERSITY   (United States)

^f GLAXOSMITHKLINE   (United States)

^g Istituto di Ricovero e Cura a Carattere Scientifico di Diritto Pubblico   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CIDOFOVIR; FOSCARNET; GANCICLOVIR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; AGED; ARTICLE; BLOOD CULTURE; CONTROLLED STUDY; CYTOMEGALOVIRUS; DRUG SENSITIVITY; FEMALE; GENE MUTATION; GENOTYPE; HUMAN; IC 50; MAJOR CLINICAL STUDY; MALE; OPPORTUNISTIC INFECTION; PHENOTYPE; PRIORITY JOURNAL; RETINITIS; RISK FACTOR; URINE CULTURE; VIRUS ISOLATION;

ADULT; AGED; AIDS-RELATED OPPORTUNISTIC INFECTIONS; ANTIVIRAL AGENTS; BLOOD; COHORT STUDIES; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS RETINITIS; DNA-DIRECTED DNA POLYMERASE; DRUG RESISTANCE, MICROBIAL; FEMALE; GANCICLOVIR; GENOTYPE; HUMANS; MALE; MIDDLE AGED; MUTATION; PHENOTYPE; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROSPECTIVE STUDIES; URINE; VIRAL PROTEINS;

EID: 0035863450     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/317931     Document Type: Article

References (18)

1. Ocular manifestations of HIV infection
2. Prevalence of resistance in patients receiving ganciclovir for serious cytomegalovirus infection
3. Cytomegalovirus resistance and viral resistance: Ganciclovir resistance
4. Incidence of foscarnet resistance and cidofovir resistance in patients treated for cytomegalovirus retinitis
5. Antiviral susceptibility testing of cytomegalovirus: Criteria for detecting resistance to antivirals
6. Viral resistance and CMV retinitis: Design and methods of a prospective study
7. Frequency of UL97 phosphotransferase mutations related to ganciclovir resistance in clinical cytomegalovirus isolates
8. Point mutations in the DNA polymerase gene of human cytomegalovirus that result in resistance to antiviral agents
9. Evolution of mutations conferring multidrug resistance during prophylaxis and therapy for cytomegalovirus disease
10. High-level resistance of cytomegalovirus to ganciclovir is associated with alterations in both the UL97 and DNA polymerase genes
11. Resistance of human cytomegalovirus to antiviral drugs
12. Analysis of the UL97 phosphotransferase coding sequence in clinical cytomegalovirus isolates and identification of mutations conferring ganciclovir resistance
13. Interstrain variation in the human cytomegalovirus DNA polymerase sequence and its effect on genotypic diagnosis of antiviral drug resistance
14. Sequence variation within three important cytomegalovirus gene regions in isolates from four different patient populations
15. Double resistance to ganciclovir and foscarnet of four human cytomegalovirus strains recovered from AIDS patients
16. Ganciclovir resistance as a result of oral ganciclovir in a heart transplant recipient with multiple human cytomegalovirus strains in blood
17. Identification of multiple strains in cytomegalovirus in homosexual men
18. Novel mutation in the CMV UL97 gene associated with resistance to ganciclovir therapy