Adenovirus-mediated gene transfer of VEGF121 improves lower-extremity endothelial function and flow reserve

Circulation

Volumn 104, Issue 7, 2001, Pages 753-755

  Rajagopalan, Sanjay ^a,d   Shah, Manan ^a   Luciano, Ann ^a   Crystal, Ronald ^c   Nabel, Elizabeth G ^b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d Women's Hospital   (United States)

Author keywords

Angiogenesis; Endothelium; Gene therapy; Growth substances; Nitric oxide

Indexed keywords

ACETYLCHOLINE; GLYCERYL TRINITRATE; VASCULOTROPIN; VIRUS VECTOR;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; GENE THERAPY; GENE TRANSFER; HEMODYNAMICS; HUMAN; LIMB BLOOD FLOW; LIMB ISCHEMIA; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL;

EID: 0035859782     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/hc3201.095192     Document Type: Article

References (11)

1. Vascular endothelial growth factor induces EDRF-dependent relaxation in coronary arteries
2. Vascular endothelial growth factor up-regulates nitric oxide synthase expression in endothelial cells
3. VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells
4. Endothelium-dependent relaxation of collateral microvessels after intramuscular gene transfer of vascular endothelial growth factor in a rat model of hindlimb ischemia
5. Recovery of disturbed endothelium-dependent flow in the collateral-perfused rabbit ischemic hindlimb after administration of vascular endothelial growth factor
6. Vascular endothelial growth factor administration in chronic myocardial ischemia
7. Local delivery of vascular endothelial growth factor accelerates reendothelialization and attenuates intimal hyperplasia in balloon-injured rat carotid artery
8. Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation
9. Nitric oxide synthase modulates angiogenesis in response to tissue ischemia
10. Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells
11. Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis