Roles of Bcl-2 and caspase 3 in the adenosine A3 receptor-induced apoptosis

Journal of Molecular Neuroscience

Volumn 17, Issue 3, 2001, Pages 285-292

  Appel, Elena ^a   Kazimirsky, Gila ^a   Ashkenazi, Ely ^b   Kim, Seong Gon ^c   Jacobson, Kenneth A ^c   Brodie, Chaya ^a  

^a BAR ILAN UNIVERSITY   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Adenosine receptor; Agonists; Apoptosis; Astrocytes; Bcl 2

Indexed keywords

1,4 DIHYDRO 2 METHYL 6 PHENYL 4 (2 PHENYLETHYNYL) 3,5 PYRIDINEDICARBOXYLIC ACID 5 BENZYL 3 ETHYL ESTER; 2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 6 N CYCLOPENTYLADENOSINE; ADENOSINE 5' (N METHYLCARBOXAMIDE); ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE A2A RECEPTOR AGONIST; ADENOSINE A3 RECEPTOR AGONIST; ADENOSINE A3 RECEPTOR ANTAGONIST; ADENOSINE DERIVATIVE; CASPASE 3; CHLORO 6 N (IODOBENZYL)ADENOSINE 5' N METHYLCARBOXAMIDE; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; ASTROCYTE; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; GENE OVEREXPRESSION; GLIA CELL; NONHUMAN; PROTEIN EXPRESSION; RAT; RECEPTOR INTRINSIC ACTIVITY;

ADENOSINE; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; ASTROCYTES; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASES; CELL CULTURE TECHNIQUES; DOWN-REGULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOBLOTTING; NEUROGLIA; PRECIPITIN TESTS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RECEPTOR, ADENOSINE A3; RECEPTORS, PURINERGIC P1; TRANSFECTION; UP-REGULATION;

ANIMALIA;

EID: 0035706502     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:17:3:285     Document Type: Article

References (23)

1. 3 adenosine receptor mediates cell spreading, reorganization of actin cytoskeleton, and distribution of Bcl-XL: Studies in human astroglioma cells
2. 2A adenosine receptor inhibits nitric oxide production in glial cells
3. Protein kinase C delta (PKCdelta) inhibits the expression of glutamine syn-thetase in glial cells via the PKCdelta regulatory domain and its tyrosine phosphorylation
4. Astrocyte activation by Sindbis virus: Expression of GFAP, cytokines, and adhesion molecules
5. 3 receptor agonists on astrocytes: Induction of cell protection at low and cell death at high concentration
6. 1 receptormediated responses in rat hippocampus
7. Nomenclature and classification of purinoceptors
8. 3-adenosine receptors. Mediation of behavioral depressant effects
9. 3 adenosine receptorselective antagonists
10. 3 adenosine receptors
11. BCL-2 gene family and the regulation of programmed cell death
12. 1 receptor
13. Identification of a p53-dependent negative response element in the bcl-2 gene
14. 2A receptors and neuroprotection
15. 1 receptor-mediated inhibition of cyclic AMP accumulation in type-2 but not type-1 rat astrocytes
16. Expression of human immunodeficiency virus type I tat results in down-regulation of bcl-2 and induction of apoptosis in hematopoietic cells
17. Protective mechanisms of adenosine in neurons and glial cells
18. Immediate early up-regulation of bax expression by p53 but not TGF beta 1: A paradigm for distinct apoptotic pathways
19. 3 adenosine receptor activation and its suppression by isoproterenol
20. 3 receptor stimulation on seizures in mice
21. 1 receptor agonist
22. 3 receptor stimulation and cerebral ischemia
23. 3 antagonists