A protein C pathway (PCP) screening test for the detection of APC resistance and protein C or S deficiencies

Seminars in Thrombosis and Hemostasis

Volumn 24, Issue 4, 1998, Pages 355-362

  Haas, Fred J L M ^a   Van Sterkenburg Kamp, Barbara M ^a   Scheepers, Helma A M M ^a  

^a ST ANTONIUS HOSPITAL   (Netherlands)

Author keywords

APC resistance; Factor V Leiden; Protein C; Protein C pathway; Protein S; Russells viper venom test; Thrombophilia

Indexed keywords

ANTICOAGULANT AGENT; PROTEIN C; VIPER VENOM;

ACTIVATED PROTEIN C RESISTANCE; AUTOMATION; BLOOD CLOTTING TIME; DIAGNOSTIC TEST; GENE MUTATION; HUMAN; PRIORITY JOURNAL; PROTEIN C DEFICIENCY; PROTEIN EXPRESSION; PROTEIN S DEFICIENCY; REVIEW; RISK FACTOR; SCREENING TEST; THROMBOPHILIA;

EID: 0031656642     PISSN: 00946176     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-996023     Document Type: Review

References (15)

1. Bertina RM, Koeleman BP, Koster T, et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994;369:64-67
2. Svensson PJ, Dahlbäck B. Resistance to activated protein C as a basis for venous thrombosis. N Engl J Med 1994;330:517-522
3. Koster T, Rosendaal FR, de Ronde H, Briet E, Vandenbroucke JP, Bertina RM. Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study. Lancet 1993;342:1503-1506
4. Seligsohn U, Zivelin A. Thrombophilia as a multigenic disorder. Thromb Haemostas 1997;78:297-301
5. Kraus M, Noah M, Fickenscher K. The PCAT - A simple screening assay for assessing the functionality of the protein C anticoagulant pathway. Thromb Res 1995;79:217-222
6. Preda L, Simioni P, Legnani C, et al. A new globel test for the evaluation of the protein C-protein S system. Blood Coag Fibrinolysis 1996;7:465-469
7. Robert A, Eschewege V, Hameg H, Drouet L, Aillaud MF. Anticoagulant response to Agkistrodon contortrix venom (ACV test): a new global test to screen for defects in the anticoagulant protein C pathway. Thromb Haemostas 1996;75:562-566
8. Denson KW, Haddon ME, Reed SV, Davidson S, Littlewood TJ. A more discriminating test for APC resistance and a possible screening test to include protein C and protein S. Thromb Res 1996;81:151-156
9. Bertina RM, Broekmans AW, van der Linden IK, Mertens K. Protein C deficiency in a Dutch family with thrombotic disease. Thromb Haemostas 1982;48:1-5
10. Deutz-Terlouw PP, Ballering L, van Wijngaarden A, Bertina RM. Two ELISA's for the measurement of protein S and their use in the laboratory diagnosis of protein S deficiency. Clin Chim Acta 1990;186:321-334
11. de Ronde H, Bertina RM. Laboratory diagnosis of APC-resistance: A critical evaluation of the test and the development of diagnostic criteria. Thromb Haemostas 1994;72:880-886
12. Jorquera JI, Montoro JM, Fernandez MA, Aznar JA, Aznar J. Modified test for activated protein C resistance. Lancet 1994; 344:1162-1163
13. Dahlbäck B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: Prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA 1993;90:1004-1008
14. Sweeney JD, Blair AJ, King TC. Comparison of an activated partial thromboplastin time with a Russell viper venom time test in screening for factor V-Leiden (FV R506Q). Am J Clin Pathol 1997;108:74-77
15. Tripodi A, Negri B, Bertina RM, Mannuci PM. Screening for the FV:Q506 mutation - Evaluation of thirteen plasma-based methods for their diagnostic efficacy in comparison with DNA analysis. Thromb Haemostas 1997;77:436-439