메뉴 건너뛰기




Volumn 12, Issue 8, 2002, Pages 325-331

Inhibition of factor VIIa/tissue factor with nematode anticoagulant protein c2: From unique mechanism to a promising new clinical anticoagulant

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT PROTEIN; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 7A; ENZYME PRECURSOR; LOW MOLECULAR WEIGHT HEPARIN; RECOMBINANT BLOOD CLOTTING FACTOR 7A; THROMBIN; THROMBOPLASTIN;

EID: 0036873001     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1050-1738(02)00185-8     Document Type: Review
Times cited : (29)

References (42)
  • 1
    • 0035525761 scopus 로고    scopus 로고
    • Thrombogenic potential of human coronary atherosclerotic plaques
    • Ardissino D., Angelica P., Bauer K.A.et al. Thrombogenic potential of human coronary atherosclerotic plaques. Blood. 98:2001;2726-2729.
    • (2001) Blood , vol.98 , pp. 2726-2729
    • Ardissino, D.1    Angelica, P.2    Bauer, K.A.3
  • 2
    • 0035970029 scopus 로고    scopus 로고
    • Combination of a brief irrigation with tissue factor pathway inhibitor (TFPI) and adenovirus-mediated local TFPI gene transfer additively reduces neointima formation in balloon-injured rabbit carotid arteries
    • Atsuchi N., Nishida T., Marutsuka K.et al. Combination of a brief irrigation with tissue factor pathway inhibitor (TFPI) and adenovirus-mediated local TFPI gene transfer additively reduces neointima formation in balloon-injured rabbit carotid arteries. Circulation. 103:2001;570-575.
    • (2001) Circulation , vol.103 , pp. 570-575
    • Atsuchi, N.1    Nishida, T.2    Marutsuka, K.3
  • 3
    • 0032549024 scopus 로고    scopus 로고
    • Regulation of extrinsic pathway factor Xa formation by tissue factor pathway inhibitor
    • Baugh R.J., Broze G.J. Jr., Krishnaswamy S. Regulation of extrinsic pathway factor Xa formation by tissue factor pathway inhibitor. J Biol Chem. 273:1998;4378-4386.
    • (1998) J Biol Chem , vol.273 , pp. 4378-4386
    • Baugh, R.J.1    Broze G.J., Jr.2    Krishnaswamy, S.3
  • 4
    • 0035971227 scopus 로고    scopus 로고
    • Role of zymogen and activated factor X as scaffolds for the inhibition of the blood coagulation factor VIIa-tissue factor complex by recombinant nematode anticoagulant protein c2
    • Bergum P.W., Cruikshank A., Maki S.L.et al. Role of zymogen and activated factor X as scaffolds for the inhibition of the blood coagulation factor VIIa-tissue factor complex by recombinant nematode anticoagulant protein c2. J Biol Chem. 276:2001;10,063-10,071.
    • (2001) J Biol Chem , vol.276 , pp. 10
    • Bergum, P.W.1    Cruikshank, A.2    Maki, S.L.3
  • 5
    • 0033395869 scopus 로고    scopus 로고
    • Low-molecular weight heparins in venous and arterial thrombotic disease
    • Bijsterveld N.R., Hettiarachchi R., Peters R.et al. Low-molecular weight heparins in venous and arterial thrombotic disease. Thromb Haemost. 82:1999;139-147.
    • (1999) Thromb Haemost , vol.82 , pp. 139-147
    • Bijsterveld, N.R.1    Hettiarachchi, R.2    Peters, R.3
  • 6
    • 0035048790 scopus 로고    scopus 로고
    • A meta-analysis of thromboembolic prophylaxis in total knee arthroplasty
    • Brookenthal K.R., Freedman K.B., Lotke P.A.et al. A meta-analysis of thromboembolic prophylaxis in total knee arthroplasty. J Arthroplasty. 16:2001;293-300.
    • (2001) J Arthroplasty , vol.16 , pp. 293-300
    • Brookenthal, K.R.1    Freedman, K.B.2    Lotke, P.A.3
  • 7
    • 0029082791 scopus 로고
    • Tissue factor pathway inhibitor
    • Broze G.J. Jr. Tissue factor pathway inhibitor. Thromb Haemost. 74:1995;90-93.
    • (1995) Thromb Haemost , vol.74 , pp. 90-93
    • Broze G.J., Jr.1
  • 8
    • 0037135531 scopus 로고    scopus 로고
    • Nematode anticoagulant protein c2 reveals a site on factor Xa that is important for macromolecular substrate binding to human prothrombinase
    • Buddai S.K., Toulokhonova L., Bergum P.W.et al. Nematode anticoagulant protein c2 reveals a site on factor Xa that is important for macromolecular substrate binding to human prothrombinase. J Biol Chem. 277:2002;22,689-26,698.
    • (2002) J Biol Chem , vol.277 , pp. 22
    • Buddai, S.K.1    Toulokhonova, L.2    Bergum, P.W.3
  • 9
    • 0034624973 scopus 로고    scopus 로고
    • Tissue factor and factor X-dependent activation of protease-activated receptor 2 by factor VIIa
    • Camerer E., Huang W., Coughlin S.R. Tissue factor and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proc Natl Acad Sci USA. 97:2000;5255-5260.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 5255-5260
    • Camerer, E.1    Huang, W.2    Coughlin, S.R.3
  • 10
    • 0029014045 scopus 로고
    • Ancylostoma caninum anticoagulant peptide: A hookworm-derived inhibitor of human coagulation factor Xa
    • Cappello M., Vlasuk G.P., Bergum P.W.et al. Ancylostoma caninum anticoagulant peptide. a hookworm-derived inhibitor of human coagulation factor Xa Proc Natl Acad Sci USA. 92:1995;6152-6156.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 6152-6156
    • Cappello, M.1    Vlasuk, G.P.2    Bergum, P.W.3
  • 11
    • 0034921205 scopus 로고    scopus 로고
    • Protease-activated receptors in vascular biology
    • Coughlin S.R. Protease-activated receptors in vascular biology. Thromb Haemost. 86:2001;298-307.
    • (2001) Thromb Haemost , vol.86 , pp. 298-307
    • Coughlin, S.R.1
  • 12
    • 0034922431 scopus 로고    scopus 로고
    • Tissue factor pathway inhibitor activity in severe sepsis
    • Creasey A.A., Reinhart K. Tissue factor pathway inhibitor activity in severe sepsis. Crit Care Med. 29:2001;S126-S129.
    • (2001) Crit Care Med , vol.29
    • Creasey, A.A.1    Reinhart, K.2
  • 13
    • 0037150191 scopus 로고    scopus 로고
    • First experience with direct factor Xa inhibition in patients with stable coronary disease: A pharmacokinetic and pharmacodynamic evaluation
    • Dyke C.K., Becker R.C., Kleiman N.S.et al. First experience with direct factor Xa inhibition in patients with stable coronary disease. a pharmacokinetic and pharmacodynamic evaluation Circulation. 105:2002;2382-2388.
    • (2002) Circulation , vol.105 , pp. 2382-2388
    • Dyke, C.K.1    Becker, R.C.2    Kleiman, N.S.3
  • 14
    • 0034912330 scopus 로고    scopus 로고
    • Role of coagulation inhibitors in inflammation
    • Esmon C.T. Role of coagulation inhibitors in inflammation. Thromb Haemost. 86:2001;51-56.
    • (2001) Thromb Haemost , vol.86 , pp. 51-56
    • Esmon, C.T.1
  • 15
    • 0035967490 scopus 로고    scopus 로고
    • Ability of recombinant factor VIIa to generate thrombin during inhibition of tissue factor in human subjects
    • Freiderich P.W., Levi M., Bauer K.A.et al. Ability of recombinant factor VIIa to generate thrombin during inhibition of tissue factor in human subjects. Circulation. 103:2001;2555-2559.
    • (2001) Circulation , vol.103 , pp. 2555-2559
    • Freiderich, P.W.1    Levi, M.2    Bauer, K.A.3
  • 16
    • 0035133938 scopus 로고    scopus 로고
    • Prevention of venous thromboembolism
    • Geerts W.H., Heit J.A., Clagett G.P.et al. Prevention of venous thromboembolism. Chest. 119(Suppl):2001;132S-175S.
    • (2001) Chest , vol.119 , Issue.SUPPL.
    • Geerts, W.H.1    Heit, J.A.2    Clagett, G.P.3
  • 17
    • 0036177902 scopus 로고    scopus 로고
    • Effective hemostasis with rFVIIa treatment in two patients with severe thrombocytopenia and life-threating hemorrhage
    • Gerotziafas G.T., Zervas C., Gavrielidis G.et al. Effective hemostasis with rFVIIa treatment in two patients with severe thrombocytopenia and life-threating hemorrhage. Am J Hematol. 69:2002;219-222.
    • (2002) Am J Hematol , vol.69 , pp. 219-222
    • Gerotziafas, G.T.1    Zervas, C.2    Gavrielidis, G.3
  • 18
    • 0029082921 scopus 로고
    • Anthrombotic benefits and hemorrhagic risks of direct thrombin antagonists
    • Harker L.A., Hanson S.R., Kelly A.B. Anthrombotic benefits and hemorrhagic risks of direct thrombin antagonists. Thromb Haemost. 74:1995;464-472.
    • (1995) Thromb Haemost , vol.74 , pp. 464-472
    • Harker, L.A.1    Hanson, S.R.2    Kelly, A.B.3
  • 19
    • 0034041209 scopus 로고    scopus 로고
    • NovoSeven as a universal haemostatic agent
    • Hedner U. NovoSeven as a universal haemostatic agent. Blood Coagul Fibrinolysis. 11:2000;S107-S111.
    • (2000) Blood Coagul Fibrinolysis , vol.11
    • Hedner, U.1
  • 20
    • 0034496733 scopus 로고    scopus 로고
    • Future possibilities in the regulation of the extrinsic pathway: RfVIIa and TFPI
    • Hedner U., Erhardtsen E. Future possibilities in the regulation of the extrinsic pathway. rfVIIa and TFPI The Finnish Society Duodecium, Ann Med. 32(Suppl 1):2000;68-72.
    • (2000) The Finnish Society Duodecium, Ann Med , vol.32 , Issue.SUPPL. 1 , pp. 68-72
    • Hedner, U.1    Erhardtsen, E.2
  • 21
    • 0035077129 scopus 로고    scopus 로고
    • Inhibition of arterial thrombosis by a soluble tissue factor mutant and active site-blocked factors IXa and Xa in the guinea pig
    • Himber J., Refino C.J., Burcklen L.et al. Inhibition of arterial thrombosis by a soluble tissue factor mutant and active site-blocked factors IXa and Xa in the guinea pig. Thromb Haemost. 85:2001;475-481.
    • (2001) Thromb Haemost , vol.85 , pp. 475-481
    • Himber, J.1    Refino, C.J.2    Burcklen, L.3
  • 22
    • 0035125405 scopus 로고    scopus 로고
    • Heparin and low-molecular-weight heparin: Mechanism of action, pharmacokinetics, dosing, monitoring, efficacy and safety
    • Hirsh J., Warkentin T.E., Shaughnessy S.G.et al. Heparin and low-molecular-weight heparin. mechanism of action, pharmacokinetics, dosing, monitoring, efficacy and safety Chest. 119(Suppl):2001;64S-94S.
    • (2001) Chest , vol.119 , Issue.SUPPL.
    • Hirsh, J.1    Warkentin, T.E.2    Shaughnessy, S.G.3
  • 23
    • 0032697246 scopus 로고    scopus 로고
    • Thrombosis and anticoagulation
    • Hirsh J., Weitz J.I. Thrombosis and anticoagulation. Sem Hematol. 36:1999;118-132.
    • (1999) Sem Hematol , vol.36 , pp. 118-132
    • Hirsh, J.1    Weitz, J.I.2
  • 24
    • 0028942281 scopus 로고
    • Surface expression and ligand-based selection of cDNAs fused to filamentous phage gene VI
    • Jespers L.S., Messens J.H., De Keyser A.et al. Surface expression and ligand-based selection of cDNAs fused to filamentous phage gene VI. Bio/Technology. 13:1995;378-382.
    • (1995) Bio/Technology , vol.13 , pp. 378-382
    • Jespers, L.S.1    Messens, J.H.2    De Keyser, A.3
  • 25
    • 0035146330 scopus 로고    scopus 로고
    • A phase II trial of intraluminal irrigation with recombinant human tissue factor pathway inhibitor to prevent thrombosis in free flap surgery
    • Khouri R.K., Sherman S., Buncke H.J.et al. A phase II trial of intraluminal irrigation with recombinant human tissue factor pathway inhibitor to prevent thrombosis in free flap surgery. Plast Reconstr Surg. 107:2001;408-415.
    • (2001) Plast Reconstr Surg , vol.107 , pp. 408-415
    • Khouri, R.K.1    Sherman, S.2    Buncke, H.J.3
  • 26
    • 0035800075 scopus 로고    scopus 로고
    • Dose-response study of recombinant factor VIIa/tissue factor inhibitor recombinant nematode anticoagulant protein c2 in prevention of postoperative venous thromboembolism in patients undergoing total knee replacement
    • Lee A., Agnelli G., Büller H.et al. Dose-response study of recombinant factor VIIa/tissue factor inhibitor recombinant nematode anticoagulant protein c2 in prevention of postoperative venous thromboembolism in patients undergoing total knee replacement. Circulation. 104:2001;74-78.
    • (2001) Circulation , vol.104 , pp. 74-78
    • Lee, A.1    Agnelli, G.2    Büller, H.3
  • 27
    • 0000386699 scopus 로고
    • The presence of a substance inhibiting the coagulation of blood in anchylostoma
    • Loeb L., Smith A.J. The presence of a substance inhibiting the coagulation of blood in anchylostoma. Proc Pathol Soc Philadelphia. 7:1904;173-178.
    • (1904) Proc Pathol Soc Philadelphia , vol.7 , pp. 173-178
    • Loeb, L.1    Smith, A.J.2
  • 28
    • 0032697618 scopus 로고    scopus 로고
    • Biochemistry and physiology of blood coagulation
    • Mann K.G. Biochemistry and physiology of blood coagulation. Thromb Haemost. 82:1999;165-174.
    • (1999) Thromb Haemost , vol.82 , pp. 165-174
    • Mann, K.G.1
  • 29
    • 79960971663 scopus 로고    scopus 로고
    • A blinded, dose-escalation phase IIa study of the fVIIa/tissue factor inhibitor rNAPc2 in patients undergoing elective percutaneous coronary angioplasty
    • [abstract]
    • Moons A., Bijsterveld N., Büller H.et al. A blinded, dose-escalation phase IIa study of the fVIIa/tissue factor inhibitor rNAPc2 in patients undergoing elective percutaneous coronary angioplasty. Blood. 98:2001;707a. [abstract].
    • (2001) Blood , vol.98
    • Moons, A.1    Bijsterveld, N.2    Büller, H.3
  • 30
    • 0034917278 scopus 로고    scopus 로고
    • Tissue factor: An enzyme cofactor and a true receptor
    • Morrissey J.H. Tissue factor. an enzyme cofactor and a true receptor Thromb Haemost. 86:2001;66-74.
    • (2001) Thromb Haemost , vol.86 , pp. 66-74
    • Morrissey, J.H.1
  • 31
    • 0035083274 scopus 로고    scopus 로고
    • Generation of a humanized, high affinity anti-tissue factor antibody for use as a novel antithrombotic therapeutic
    • Presta L., Sims P., Meng Y.G.et al. Generation of a humanized, high affinity anti-tissue factor antibody for use as a novel antithrombotic therapeutic. Thromb Haemost. 85:2001;379-389.
    • (2001) Thromb Haemost , vol.85 , pp. 379-389
    • Presta, L.1    Sims, P.2    Meng, Y.G.3
  • 32
    • 0034040810 scopus 로고    scopus 로고
    • Active site-blocked activated factor VII as an effective antithrombotic agent: Mechanism of action
    • Rao L.V.M., Ezban M. Active site-blocked activated factor VII as an effective antithrombotic agent. mechanism of action Blood Coagul Fibrinolysis. 11:2000;S135-S143.
    • (2000) Blood Coagul Fibrinolysis , vol.11
    • Rao, L.V.M.1    Ezban, M.2
  • 33
    • 0034933683 scopus 로고    scopus 로고
    • Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor
    • Riewald M., Ruf W. Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor. Proc Natl Acad Sci USA. 98:2001;7742-7747.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 7742-7747
    • Riewald, M.1    Ruf, W.2
  • 34
    • 0033573837 scopus 로고    scopus 로고
    • Importance of factor VIIa gla-domain residue Arg-36 for recognition of the macromolecular substrate factor X gla-domain
    • Ruf W., Shobe J., Rao S.M.et al. Importance of factor VIIa gla-domain residue Arg-36 for recognition of the macromolecular substrate factor X gla-domain. Biochemistry. 38:1999;1957-1966.
    • (1999) Biochemistry , vol.38 , pp. 1957-1966
    • Ruf, W.1    Shobe, J.2    Rao, S.M.3
  • 35
    • 0000455702 scopus 로고    scopus 로고
    • Antocoagulant repertoire of the hookworm Ancylostoma caninum
    • Stanssens P., Bergum P.W., Gansemans Y.et al. Antocoagulant repertoire of the hookworm Ancylostoma caninum. Proc Natl Acad Sci USA. 93:1996;2149-2154.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 2149-2154
    • Stanssens, P.1    Bergum, P.W.2    Gansemans, Y.3
  • 36
    • 0025904459 scopus 로고
    • Lethal E. coli septic shock is prevented by blocking tissue factor with monoclonal antibody
    • Taylor F.B. Jr., Chang A., Ruf W.et al. Lethal E. coli septic shock is prevented by blocking tissue factor with monoclonal antibody. Circ Shock. 33:1991;127-134.
    • (1991) Circ Shock , vol.33 , pp. 127-134
    • Taylor F.B., Jr.1    Chang, A.2    Ruf, W.3
  • 38
    • 0001627096 scopus 로고    scopus 로고
    • Early clinical evaluation of rNAPc2, a novel inhibitor of blood coagulation factor VIIa/tissue factor (fVIIa/TF)
    • [abstract]
    • Vlasuk G.P., Bradbury A.E., Bergum P.W.et al. Early clinical evaluation of rNAPc2, a novel inhibitor of blood coagulation factor VIIa/tissue factor (fVIIa/TF). J Am Coll Cardiol. 33:1999;255A-256A. [abstract].
    • (1999) J Am Coll Cardiol , vol.33
    • Vlasuk, G.P.1    Bradbury, A.E.2    Bergum, P.W.3
  • 39
    • 33645545971 scopus 로고    scopus 로고
    • Stochiometric binding to zymogen factor X determines the in vivo fate of rNAPc2 in man
    • [abstract]
    • Vlasuk G.P., Maki S., Cruikshank A.et al. Stochiometric binding to zymogen factor X determines the in vivo fate of rNAPc2 in man. Blood. 92:1998;361A. [abstract].
    • (1998) Blood , vol.92
    • Vlasuk, G.P.1    Maki, S.2    Cruikshank, A.3
  • 40
    • 0037176941 scopus 로고    scopus 로고
    • Direct thrombin inhibitors in acute coronary syndromes. Present and future
    • Weitz J.I., Büller H.R. Direct thrombin inhibitors in acute coronary syndromes. Present and future. Circulation. 105:2002;1004-1011.
    • (2002) Circulation , vol.105 , pp. 1004-1011
    • Weitz, J.I.1    Büller, H.R.2
  • 41
    • 0035128439 scopus 로고    scopus 로고
    • New anticoagulant drugs
    • Weitz J.I., Hirsh J. New anticoagulant drugs. Chest. 119(Suppl):2001;95S-107S.
    • (2001) Chest , vol.119 , Issue.SUPPL.
    • Weitz, J.I.1    Hirsh, J.2
  • 42
    • 0033179471 scopus 로고    scopus 로고
    • Extensive venous and arterial thrombosis associated with an inhibitor to activated protein C
    • Zivelin A., Gitel S., Griffin J.H.et al. Extensive venous and arterial thrombosis associated with an inhibitor to activated protein C. Blood. 94:1999;895-901.
    • (1999) Blood , vol.94 , pp. 895-901
    • Zivelin, A.1    Gitel, S.2    Griffin, J.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.