Role of Zymogen and Activated Factor X as Scaffolds for the Inhibition of the Blood Coagulation Factor VIIa-Tissue Factor Complex by Recombinant Nematode Anticoagulant Protein c2

Journal of Biological Chemistry

Volumn 276, Issue 13, 2001, Pages 10063-10071

  Bergum, Peter W ^a   Cruikshank, Amy ^a   Maki, Steven L ^a   Kelly, Curtis R ^b,c   Ruf, Wolfram ^b   Vlasuk, George P ^a  

^a Dendreon   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c ALCON RESEARCH LTD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; BLOOD; DERIVATIVES; ENZYME INHIBITION; PHOSPHOLIPIDS; RNA; TISSUE;

BLOOD COAGULATION FACTORS;

PROTEINS;

4 CARBOXYGLUTAMIC ACID; ANTICOAGULANT PROTEIN; ANTICOAGULANT PROTEIN C2; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 7A; ENZYME PRECURSOR; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLSERINE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; ANTI COAGULANT PROTEIN C2, ANCYLOSTOMA CANINUM; ANTI-COAGULANT PROTEIN C2, ANCYLOSTOMA CANINUM; ANTICOAGULANT AGENT; CANCER PROCOAGULANT; CYSTEINE PROTEINASE; HELMINTH PROTEIN; PHOSPHOLIPID; TUMOR PROTEIN;

ANTICOAGULATION; ARTICLE; BLOOD CLOTTING; CONTROLLED STUDY; ENZYME ACTIVE SITE; HYDROLYSIS; NEMATODE; NONHUMAN; PHOSPHOLIPID MEMBRANE; PRIORITY JOURNAL; ANIMAL; BINDING SITE; BIOLOGICAL MODEL; CELL MEMBRANE; CHEMICAL MODEL; CHEMISTRY; CHO CELL; DOSE RESPONSE; HAMSTER; HUMAN; KINETICS; METABOLISM; MUTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SURFACE PLASMON RESONANCE; TICK; TIME;

ANIMALS; ANTICOAGULANTS; BINDING SITES; CATALYTIC DOMAIN; CELL MEMBRANE; CHO CELLS; CRICETINAE; CYSTEINE ENDOPEPTIDASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME PRECURSORS; FACTOR VIIA; FACTOR XA; HELMINTH PROTEINS; HUMANS; HYDROLYSIS; KINETICS; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MUTATION; NEOPLASM PROTEINS; PHOSPHOLIPIDS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SURFACE PLASMON RESONANCE; TICKS; TIME FACTORS;

EID: 0035971227     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M009116200     Document Type: Article

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