High-level expression of immunoreactive recombinant cat allergen (Fel d 1): Targeting to antigen-presenting cells

Journal of Allergy and Clinical Immunology

Volumn 110, Issue 5, 2002, Pages 757-762

  Vailes, Lisa D ^a   Sun, Amanda W ^b   Ichikawa, Kunio ^c,d   Wu, Zining ^b   Sulahian, Timothy H ^b   Chapman, Martin D ^a,d   Guyre, Paul M ^b  

^a INDOOR Biotechnologies Inc   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF TSUKUBA   (Japan)

^d UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Antigen presenting cells; Asthma; Cat allergen; Immunotherapy; In vitro diagnostics

Indexed keywords

ALLERGEN; CD64 ANTIGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; RECOMBINANT CAT ALLERGEN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ALLERGY; ANIMAL CELL; ANTIGEN BINDING; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; ASTHMA; BACULOVIRUS EXPRESSION SYSTEM; CELL SUBPOPULATION; ENZYME IMMUNOASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; IMMUNOTHERAPY; LEUKOCYTE; LYMPHOCYTE; MONOCYTE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; RADIOIMMUNOASSAY; RECEPTOR BINDING; RECOMBINANT DNA TECHNOLOGY;

EID: 0036857557     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2002.129035     Document Type: Article

References (39)

1. Ohman JL, Lowell FC, Block KJ. Allergens of mammalian origin. III. Properties of a major feline allergen. J Immunol 1974;113:1168-77.
2. Leitermann K, Ohman JL. Cat allergen 1: Biochemical, antigenic, and allergenic properties. J Allergy Clin Immunol 1984;74:147-53.
3. Lowenstein H, Lind P, Weeke B. Identification and clinical significance of allergenic molecules of cat origin. Allergy 1985;40:430-41.
4. van Ree R, van Leeuwen A, Bulder I, Bond J, Aalberse RC. Purified natural and recombinant Fel d 1 and cat albumin in in vitro diagnostics for cat allergy. J Allergy Clin Immunol 1999;104:1223-30.
5. Ichikawa K, Vailes LD, Pomés A, Chapman MD. Molecular cloning, expression and modeling of cat allergen, cystatin (Fel d 3), a cysteine protease inhibitor. Clin Exp Allergy 2001;31:1279-86.
6. Péne J, Descroches A, Paradis L, et al. Immunotherapy with Fel d 1 peptides decreases IL-4 release by peripheral blood T cell of patients allergic to cats. J Allergy Clin Immunol 1998;102:571-8.
7. Prescott S, Macaubas C, Smallacombe T, Holt BJ, Sly PD, Holt PG. Development of allergen-specific T-cell memory in atopic and normal children. Lancet 1999;353:196-200.
8. Larché M, Haselden BM, Oldfield WLG, et al. Mechanisms of T cell peptide epitope-dependent late asthmatic reactions. Int Arch Allergy Immunol 2001;124:272-5.
9. Finn PW, Boudreau JO, He H, et al. Children at risk for asthma: Home allergen levels, lymphocyte proliferation, and wheeze. J Allergy Clin Immunol 2000;105:933-42.
10. Platts-Mills TAE, Sporik R, Squillace SP, Woodfolk J, Vaughan J. Decreased risk of sensitization and asthma in children with high exposure to cat allergen is associated with a modified Th2 response. Lancet 2001;357:752-6.
11. Ichikawa K, Iwasaki E, Baba M, Chapman MD. High prevalence of sensitization to cat allergen among Japanese children with asthma, living without cats. Clin Exp Allergy 1999;29:754-61.
12. Chapman MD, Wood RA. The role and remediation of animal allergens in allergic diseases. J Allergy Clin Immunol 2001;107:S414-21.
13. van Ree R. Analytic aspects of the standardization of allergenic extracts. Allergy 1997;52:795-805.
14. American Academy of Allergy, Asthma and Immunology (AAAAI). Position Statement: The use of standardized allergen extracts. J Allergy Clin Immunol 1997;99:583-6.
15. Chapman MD, Smith AM, Vailes LD, Arruda LK, Dhanaraj V, Pomes A. Recombinant allergens for diagnosis and therapy of allergic disease. J Allergy Clin Immunol 2000;106:409-18.
16. Duffort OA, Carreira J. Nitti G, Polo F, Lombardero M. Studies on the biochemical structure of the major cal allergen Felis domesticus 1. Mol Immunol 1991;28:301-9.
17. Morgenstern JP, Griffith IJ, Brauer AW, et al. Amino acid sequence of Fel d 1, the major allergen of the domestic cat: Protein sequence analysis and cDNA cloning. Proc Natl Acad Sci U S A 1991;88:9690-4.
18. Slunt JB, Rogers BL, Chapman MD. IgE antibodies to recombinant forms of Fel d 1: Dichotomy between fluid-phase and solid-phase binding studies. J Allergy Clin Immunol 1995;95:1221-8.
19. Rogers BL, Morgenstern JP, Garman RD, Bond JF, Kuo MC. Recombinant Fel d 1: Expression, purification, IgE binding and reaction with cat-allergic human T cells. Mol Immunol 1993;30:559-68.
20. Counsell CM, Bond JF, Ohman JL, Greenstein JL, Garman RD. Definition of the human T-cell epitopes of Fel d 1, the major allergen of the domestic cat. J Allergy Clin Immunol 1996;98:884-94.
21. Haselden BM, Kay AB, Larché M. Immunoglobulin E-independent major histocompatibility complex-restricted T cell peptide epitope-induced late asthmatic reactions. J Exp Med 1999;189:1885-94.
22. Maguire P, Nicodemus C, Robinson D, Aaronson D, Umetsu DT. The safety and efficacy of ALLERVAX CAT in cat allergic patients. Clin Immunol 1999;93:222-31.
23. Keler T, Guyre PM, Vitale LA, et al. Targeting weak antigens to CD64 elicits potent humoral responses in human CD64 transgenic mice. J Immunol 2000;165:6738-42.
24. Fanger NA, Voigtlaender D, Liu C, et al. Characterization of expression, cytokine regulation, and effector function of the high affinity IgG receptor Fc gamma RI (CD64) expressed on human blood dendritic cells. J Immunol 1997;158:3090-8.
25. Van Vugt MJ, Kleijmeer MJ, Keler T, et al. The FcγRIa (CD64) ligand binding chain triggers major histocompatibility complex class II antigen presentation independently of its associated FcR γ-chain. Blood 1999;94:808-17.
26. Raag R, Whitlow M, Single-chain Fvs. FASEB J 1995;9:73-80.
27. De Groot H, van Swieten P, van Leeuwen J, Lind P, Aalberse RC. Monoclonal antibodies to the major feline allergen Fel d 1. I. Serologic and biologic activity of affinity purified Fel d 1 and of Fel d I-depleted extract. J Allergy Clin Immunol 1988;82:778-86.
28. Chapman MD, Aalberse RC, Brown MJ, Platts-Mills TAE. Monoclonal antibodies to the major feline allergen Fel d 1. II. Single step affinity purification of Fel d 1, N-terminal sequence analysis, and development of a sensitive two-site immunoassay to assess Fel d I exposure. J Immunol 1988;140:812-8.
29. Morganelli PM, Guyre PM. IFN-gamma plus glucocorticoids stimulate the expression of a newly identified human mononuclear phagocyte-specifiec antigen. J Immunol 1988;140:2296-304.
30. Hoffman RA, Kung PC, Hansen WP, Goldstein G. Simple and rapid measurement of human T lymphocytes and their subclasses and their subclasses in peripheral blood. Proc Natl Acad Sci U S A 1980;77:4914-7.
31. Keler T, Graziano RF, Mandal A, et al. Bispecific antibody-dependent cellular cytotoxicity of HER2/neu overexpressing tumor cells by Fc gamma receptor type I-expressing effector cells. Cancer Res 1997;57:4008-14.
32. Best EA, Stedman KE, Bozic CM, et al. A recombinant Group 1 house dust mite allergen, rDer f 1, with biological activities similar to those of the native allergen. Protein Expr Purif 2000;20:462-71.
33. Smith SM, Benjamin DC, Hozic N. et al. The molecular basis of antigenic cross-reactivity between the group 2 mite allergens. J Allergy Clin Immunol 2001;107:977-84.
34. Vailes LD, Ichikawa K, Pomés A, et al. Validation of recombinant allergens: ELISA reactivity, IgE antibody binding, and skin test reactivity [abstract]. J Allergy Clin Immunol 2001;107:S219.
35. Vailes LD, Ying L, Yongde B, Degroot H, Aalberse RC, Chapman MD. Fine specificity of B-cell epitopes on Fells domesticus allergen 1 (Fel d 1): Effect of reduction and alkylation or deglycosylation on Fel d 1 structure and antibody binding. J Allergy Clin Immunol 1994;93:22-33.
36. Wallace PK, Tsang KW, Goldstein J, et al. Exogenous antigen targeted to FcγRI on myeloid cells is presented in association with MHC classI. J Immunol Methods 2001;248:183-94.
37. Okayama Y, Kirshenbaum AS, Metcalfe DD. Expression of a functional high affinity 1gG receptor, FcγRI on human mast cells. J Immunol 2000;164:4332-9.
38. Hiller R, Laffer S, Harwanegg C, et al. Microarrayed allergen molecules: Diagnostic gatekeepers for allergy treatment. FASEB J 2002;16:414-6.
39. Kraft D, Ferreira F, Vrtala S, et al. The importance of recombinant allergens for diagnosis and therapy of IgE-mediated allergies. Int Arch Allergy Immunol 1999;118:171-6.