A single dose of oral DNA immunization delivered by attenuated Salmonella typhimurium down-regulates transgene expression in HBsAg transgenic mice

European Journal of Immunology

Volumn 32, Issue 11, 2002, Pages 3294-3304

  Zheng, Bo Jian ^a   Ng, Mun Hon ^a   Chan, Koh Wah ^a   Tam, Sidney ^b   Woo, Patrick C Y ^a   Ng, Sze Park ^a   Yuen, Kwok Yung ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b QUEEN MARY HOSPITAL   (Hong Kong)

Author keywords

Inhibition of HBV transgene; Oral DNA vaccination; T cell immunity

Indexed keywords

ALANINE AMINOTRANSFERASE; DNA VACCINE; HEPATITIS B SURFACE ANTIBODY; HEPATITIS B SURFACE ANTIGEN; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN SUBCLASS; MESSENGER RNA; PLASMID DNA; RECOMBINANT ANTIGEN; VIRUS ANTIGEN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; CELL ACTIVATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; GENE EXPRESSION REGULATION; HEPATITIS B; HISTOPATHOLOGY; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGLOBULIN PRODUCTION; IMMUNOLOGICAL TOLERANCE; LIVER CELL; LIVER FUNCTION; MALE; MICROBIAL ATTENUATION; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; REVIEW; SALMONELLA TYPHIMURIUM; SINGLE DRUG DOSE; TH1 CELL; TRANSGENE; TRANSGENIC MOUSE;

ADMINISTRATION, ORAL; ANIMALS; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION; HEPATITIS B ANTIBODIES; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VACCINES; IMMUNIZATION; LIVER; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; SALMONELLA TYPHIMURIUM; T-LYMPHOCYTES, CYTOTOXIC; TH1 CELLS; TRANSCRIPTION, GENETIC; TRANSGENES; VACCINES, DNA;

EID: 0036856573     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200211)32:11<3294::AID-IMMU3294>3.0.CO;2-D     Document Type: Review

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