Drug-induced hypothermia begun 5 minutes after injury with a poly(adenosine 5′-diphosphate-ribose) polymerase inhibitor reduces hypoxic brain injury in rat pups

Critical Care Medicine

Volumn 30, Issue 11, 2002, Pages 2420-2424

  Feng, Yangzheng ^a   LeBlanc, Michael H ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Focal ischemia; Neuroprotection; Poly(adenosine 5 diphosphate ribose) polymerase; Stroke

Indexed keywords

1,11B DIHYDRO 2H BENZOPYRANO[4,3,2 DE]ISOQUINOLIN 3 ONE; GPI 6150; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; BRAIN HYPOXIA; BRAIN INJURY; BRAIN WEIGHT; CAROTID ARTERY LIGATION; CONTROLLED STUDY; CORE TEMPERATURE; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; HEMISPHERE; HYPOTHERMIA; NEWBORN; NEWBORN HYPOXIA; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL; RAT; RECTUM TEMPERATURE; SCORING SYSTEM;

EID: 0036852045     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200211000-00003     Document Type: Article

References (30)

1. Pieper AA, Verma A, Zhang J, et al: Poly (ADP-ribose) polymerase, nitric oxide and cell death. Trends Pharmacol Sci 1999; 20:171-181
2. Schlicker A, Peschke P, Burkle A, et al: 4-Amino-1,8-naphthalimide: A novel inhibitor of poly(ADP-ribose) polymerase and radiation sensitizer. Int J Radiat Biol 1999; 75:91-100
3. Endres M, Wang ZQ, Namura S, et al: Ischemic brain injury is mediated by the activation of poly(ADP-ribose) polymerase. J Cereb Blood Flow Metab 1997; 17:1143-1151
4. Eliasson MJL, Sampei K, Mandir AS, et al: Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nat Med 1997; 3:1089-1095
5. Zingarelli B, Cuzzocrea S, Zsengeller Z, et al: Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly(ADP-ribose) synthetase. Cardiovasc Res 1997; 36:205-215
6. Cuzzocrea S, Zingarelli B, Costantino G, et al: Beneficial effects of 3-aminobenzamide, an inhibitor of poly(ADP-ribose) synthetase in a rat model of splanchnic artery occlusion and reperfusion. Br J Pharmacol 1997; 122:1065-1074
7. Chatterjee PK, Thiemermann C: Inhibitors of poly(ADP-ribose) synthetase protect rat renal proximal tubular cells against oxidant stress. Biochem Soc Trans 1998; 26:S318
8. Tasker RC, Sahota SK, Cotter FE, et al: Early postischemic dantrolene-induced amelioration of poly(ADP-ribose) polymerase-related bioenergetic failure in neonatal rat brain slices. J Cereb Blood Flow Metab 1998; 18:1346-1356
9. Herceg Z, Wang ZQ: Failure of poly(ADP-ribose) polymerase cleavage by caspases leads to induction of necrosis and enhanced apoptosis. Mol Cell Biol 1999; 19:5124-5133
10. Takahashi K, Greenberg JH: The effect of reperfusion on neuroprotection using an inhibitor of poly(ADP-ribose) polymerase. Neuroreport 1999; 10:2017-2022
11. Milam KM, Cleaver JE: Inhibitors of poly(adenosine diphosphate-ribose) synthesis: Effect on other metabolic processes. Science 1984; 223:589-591
12. Takshashi K, Pieper AA, Croul SE, et al: Post-treatment with an inhibitor of poly(ADP-ribose) polymerase attenuates cerebral damage in focal ischemia. Brain Res 1999; 829:46-54
13. Zhang J, Lautar S, Huang S, et al: GPI 6150 prevents H202 cytotoxicity by inhibiting poly(ADP-ribose) polymerase. Biochem Biophys Res Com 2000; 278:590-598
14. Vannucci RC, Connor JR, Mauger DT: Rat model of perinatal hypoxic-ischemic brain damage. J Neurosci Res 1999; 55:158-163
15. Dietrich WD, Busto R, Alonso O, et al: Intraischemic but not postischemic brain hypothermia protects chronically following global forebrain ischemia in rats. J Cereb Blood Flow Metab 1993; 13:541-549
16. Colbourne F, Li H, Buchan AM: Indefatigable CA1 sector neuroprotection with mild hypothermia induced 6 hours after severe forebrain ischemia in rats. J Cereb Blood Flow Metab 1999; 19:742-749
17. LeBlanc MH, Feng YZ, Fratkin JD: TPCK pretreatment reduces hypoxic ischemic brain injury in the newborn rat. Eur J Pharmacol 2000; 390:249-256
18. Zhang J, Li JH, Lautar S: Post-ischemic protection by a potent PARP inhibitor in transient cerebral focal ischemia. Abstr Soc Neurosci 1998; 24:1226
19. Lautar S, Peiper AA, Verma A, et al: Post-ischemic treatment with GPI 6150 diminishes poly(ADP-ribose) accumulation during ischemia reperfusion injury in rat brain. Abstr Soc Neurosci 1998; 24:1126
20. Ducrocq S, Benjelloun N, Plotkine M, et al: Poly(ADP-ribose) synthase inhibition reduces ischemic injury and inflammation in neonatal rat brain. J Neurochem 2000; 74:2504-2511
21. Bona E, Johansson BB, Hagberg H: Sensorimotor function and neuropathology five and six weeks after hypoxia-ischemia in seven-day-old rats. Pediatr Res 1997; 42:678-683
22. Hagberg H, Gilland E, Diemer N, et al: Hypoxia-ischemia in the neonatal rat brain: Histopathology after post-treatment with NMDA and non-NMDA receptor antagonists. Biol Neonate 1994; 66:205-213
23. Bona E, Hagberg H, Loberg EM, et al: Protective effects of moderate hypothermia after neonatal hypoxia-ischemia: Short- and long-term outcome. Pediatr Res 1998; 43:738-745
24. Yager J, Towfighi J, Vannucci RC: Influence of mild hypothermia on hypoxic-ischemic brain damage in the immature rat: Pediatr Res 1993; 34:525-529
25. Laptook AR, Corbett RJT, Sterett R, et al: Modest hypothermia provides partial neuroprotection when used for immediate resuscitation after brain ischemia. Pediatr Res 1997; 42:17-23
26. Gunn AJ, Gunn TR, de Haan HH, et al: Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs. J Clin Invest 1997; 99:248-256
27. Krieger DW, De Georgia MA, Abou-Chebl A, et al: Cooling for acute ischemic brain damage (cool aid): An open pilot study of induced hypothermia in acute ischemic stroke. Stroke 2001; 32:1847-1854
28. Azzoparti D, Robertson NJ, Cowan FM, et al: Pilot study of treatment with whole body hypothermia for neonatal encephalopathy. Pediatrics 2000; 106:684-694
29. Kleiber M: The Fire of Life: An Introduction to Animal Energetics. New York, Wiley, 1961
30. Takahashi K, Greenberg JH, Jackson P, et al: Neuroprotective effects of inhibiting poly(ADP-ribose) synthetase on focal cerebral ischemia in rats. J Cereb Blood Flow Metab 1997; 17:1137-1142