Checkpoint genes in cancer

Annals of Medicine

Volumn 33, Issue 2, 2001, Pages 113-122

  McDonald III, E R ^a   El Deiry, W S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Checkpoints; Cyclin dependent kinases; Oncogenes; Tumour suppressor genes

Indexed keywords

CELL DNA; CYCLIN DEPENDENT KINASE; CYCLINE; LAMININ; MICROTUBULE ASSOCIATED PROTEIN 4; PROTEIN P21; PROTEIN P53; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F;

ARTICLE; CARCINOGENESIS; CELL CYCLE; DNA DAMAGE; ENZYME ACTIVITY; GENE CONTROL; GENE EXPRESSION REGULATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTO ONCOGENE; TUMOR SUPPRESSOR GENE;

EID: 0035046397     PISSN: 07853890     EISSN: None     Source Type: Journal    
DOI: 10.3109/07853890109002066     Document Type: Article

References (82)

1. Lessons from hereditary colorectal cancer
2. Cancer cell cycles
3. Creation of human tumour cells with defined genetic elements
4. Cell cycle control as a basis for cancer drug development
5. Mutations of mitotic checkpoint genes in human cancers
6. Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5′ CpG island methylation
7. The DNA damage response: Putting checkpoints in perspective
8. Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
9. The Rb/E2F pathway: Expanding roles and emerging paradigms
10. 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage
11. Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization
12. Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions
13. Inhibition of eukaryotic DNA replication by geminin binding to cdt1
14. Anticancer drug targets: Cell cycle and checkpoint control
15. Purification of maturation-promoting factor, an intracellular regulator of early mitotic events
16. Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division
17. Principles of CDK regulation
18. Rb interacts with histone deacetylase to repress transcription
19. BRG-1 is required for RB-mediated cell cycle arrest
20. Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1
21. Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF
22. Initiation of DNA replication in eukaryotic cells
23. Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization
24. A role for Cdk2 kinase in negatively regulating DNA replication during S phase of the cell cycle
25. Conducting the mitotic symphony
26. Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics
27. Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo
28. Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis
29. Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation
30. Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control
31. Structural basis of cyclin-dependent kinase activation by phosphorylation
32. A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase
33. Oncoprotein networks
34. The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts
35. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
36. WAF1, a potential mediator of p53 tumor suppression
37. A checkpoint on the road to cancer
38. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B
39. Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis
40. Chfr defines a mitotic stress checkpoint that delays entry into metaphase
41. Radiosensitivity in ataxia-telangiectasia: A new explanation
42. Cell cycle checkpoints: Preventing an identity crisis
43. A DNA damage checkpoint meets the cell cycle engine
44. Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein
45. Rapid destruction of human Cdc25A in response to DNA damage
46. Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
47. DNA damage-induced activation of p53 by the checkpoint kinase Chk2
48. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
49. Enhanced phosphorylation of p53 by ATM in response to DNA damage
50. Surfing the p53 network
51. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
52. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
53. 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression
54. Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase
55. Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks
56. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
57. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
58. Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells
59. A novel cyclin encoded by a bcl1-linked candidate oncogene
60. Enhanced protein stability: A novel mechanism of D-type cyclin over-abundance identified in human sarcoma cells
61. Cyclin D1 oncoprotein aberrantly accumulates in malignancies of diverse histogenesis
62. Cyclin E, a potential prognostic marker for breast cancer
63. Amplification of cyclin genes in colorectal carcinomas
64. A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma
65. Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer
66. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
67. The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas
68. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas
69. Loss or altered subcellular localization of p27 in Barrett's associated adenocarcinoma
70. CDC25 phosphatases as potential human oncogenes
71. Somatic mutation of the hBUB1 mitotic checkpoint gene in primary lung cancer
72. Genomic instability at the BUB1 locus in colorectal cancer, but not in non-small cell lung cancer
73. Mutation analysis of hBUB1 in aneuploid HNSCC and lung cancer cell lines
74. Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1
75. ATR disruption leads to chromosomal fragmentation and early embryonic lethality
76. The p53 pathway and apoptosis
77. Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
78. Nucleolar Arf sequesters Mdm2 and activates p53
79. Amplification of a gene encoding a p53-associated protein in human sarcomas
80. p53 mutation and MDM2 amplification in human soft tissue sarcomas
81. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
82. Distinct somatic genetic changes associated with tumor progression in carriers of BRCA1 and BRCA2 germ-line mutations