Progesterone antagonists increase androgen receptor expression in the rhesus macaque and human endometrium

Journal of Clinical Endocrinology and Metabolism

Volumn 86, Issue 6, 2001, Pages 2668-2679

  Slayden, Ov D ^a   Nayak, Nihar R ^a   Burton, Kevin A ^b   Chwalisz, Kristof ^c,d   Cameron, Sharon T ^b   Critchley, Hilary O D ^b   Baird, David T ^b   Brenner, Robert M ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c BAYER PHARMA AG   (Germany)

^d TAP Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ANTIGESTAGEN; ESTRADIOL; MIFEPRISTONE; PROGESTERONE;

ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENDOMETRIUM; FEMALE; HORMONE ACTION; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IN SITU HYBRIDIZATION; MENSTRUAL CYCLE; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION;

ANIMALS; DRUG SYNERGISM; ENDOMETRIUM; ESTRADIOL; FEMALE; HORMONE ANTAGONISTS; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MACACA MULATTA; MIFEPRISTONE; OVARIECTOMY; PROGESTERONE; RECEPTORS, ANDROGEN; UP-REGULATION;

ANIMALIA; MACACA; MACACA MULATTA; PRIMATES;

EID: 0034967057     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.86.6.2668     Document Type: Article

References (41)

1. Delayed endometrial maturation induced by daily administration of the antiprogestin RU 486: A potential new contraceptive strategy
2. Contraceptive efficacy of low doses of mifepristone
3. Effects of daily low dose mifeptistone on endometrial maturation and proliferation
4. Chronic treatment of cycling rhesus monkeys with low doses of the antiprogestin ZK 137 316: Morphometric assessment of the uterus and oviduct
5. Noncompetitive antiestrogenic effect of RU 486 in blocking the estrogen-stimulated luteinizing hormone surge and the proliferative action of estradiol on endometrium in castrate monkeys
6. Estrogen action in the reproductive tract of rhesus monkeys during antiprogestin treatment
7. RU 486 action after estrogen priming in the endometrium and oviducts of rhesus monkeys (Macaca mulatta)
8. Histological changes in the genital tract in transsexual women following androgen therapy
9. Histopathological effects of exogenously administered testosterone in 19 female to male transsexuals
10. The action of testosterone propionate on the uterus and breast
11. Serum androgen levels in women who have recurrent miscarriages and their correlation with markers of endometrial function
12. Androgens suppress estrogen and progestin receptors in the endometrium and oviduct of rhesus monkeys
13. Immunohistochemical localization of androgen receptor in the human endometrium, decidua, placenta and pathological conditions of the endometrium
14. Androgen receptor content in human endometrium
15. Immunocytochemical localization of androgen receptor with polyclonal antibody in paraffin-embedded human tissues: Authors' response
16. Androgen receptor expression in human tissues: An immunohistochemical study
17. Androgen receptor expression in human ovarian and uterine tissue of long term androgen-treated transsexual women
18. Location and sex steroid regulation of androgen receptor gene espression in rhesus monkey uterus
19. The effect of estrogen and androgen on androgen receptors and mRNA levels in uterine leiomyoma, myometrium and endometrium of human subjects
20. Dating the endometrial biopsy
21. Effect of two antiprogestins (mifpristone and onapristone) on endometrial factors of potential importance for implantation
22. Cyclic changes in the primate oviduct and endometrium
23. Microwave stabilization enhances immunocytochemical detection of estrogen receptor in frozen sections of macaque oviduct
24. Immunocytochemical localization of androgen receptors in brains of developing and adult male rhesus monkeys
25. A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid
26. Regulation of androgen receptor expression in the human heterotransplantable prostate carcinoma PC-82
27. Brief, high-temperature heat denaturation (pressure cooking): A simple and effective method of antigen retrieval for routinely processed tissues
28. Androgen receptor messenger ribonucleic acid in brains and pituitaries of male rhesus monkeys: Studies of distribution, hormonal control, and relationship to luteinizing hormone secretion
29. Progesterone withdrawl up-regulates vascular endothelial growth factor receptor type-2 in the superficial zone stroma of the human and macaque endometrium: Potential relevance to menstruation
30. Design and analysis of experiments, ed 66
31. The effects of progesterone on the patterns of testosterone and estradiol concentrations in the systemic plasma of the female rhesus monkey during the intermenstrual period
32. Behavior and origin of plasma androgens throughout the menstrual cycle
33. RU 486 (Mifepristone): Induction of dose dependent elevations of estradiol receptor in endometrium from ovariectomized monkeys
34. Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities
35. Inhibition of the estradiol-mediated endometrial gland formation by the antigestagen onapristone in rabbits: Relationship to uterine estrogen receptors
36. Stimulation of gonadotropin-releasing hormone surges by estrogen.1. Role of hypothalamic progesterone receptors
37. The inhibitory effects of danazol, danazol metabolites, gestrinone, and testosterone on the growth of human endometrial cells in vitro
38. Do androgens have a direct effect on endometrial function? An in vitro study
39. Endocrine abnormalities during the follicular phase in women with recurrent spontaneous abortion
40. Polycystic ovaries and levels of gonadotropins and androgens in recurrent miscarriage: Prospective study in 50 women
41. The effects of RU 486 and leuprolide acetate on uterine artery blood flow in the fibroid uterus: A prospective, randomized study