Growth inhibition of human mammary carcinoma by liposomal hexadecylphosphocholine: Participation of activated macrophages in the antitumor mechanism

International Journal of Cancer

Volumn 92, Issue 3, 2001, Pages 426-433

  Eue, Ines ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Hexadecylphosphocholine; IL 6; Liposomes; Macrophage; Mammary carcinoma; MDA MB 231; MDA MB 435; TNF

Indexed keywords

COLLAGENASE; INTERFERON; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MATRIX METALLOPROTEINASE INHIBITOR; MILTEFOSINE; NITRIC OXIDE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER INHIBITION; CYTOKINE RELEASE; CYTOTOXICITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GROWTH INHIBITION; HUMAN; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; TUMOR CELL LINE; ZYMOGRAPHY;

ANIMALS; ANTINEOPLASTIC AGENTS; DISEASE MODELS, ANIMAL; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HUMANS; INTERLEUKIN-6; LIPOSOMES; LYMPHOCYTES, TUMOR-INFILTRATING; MACROPHAGE ACTIVATION; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; MICE, NUDE; NEOPLASMS, EXPERIMENTAL; PHOSPHORYLCHOLINE; RNA, MESSENGER; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0035342579     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.1201     Document Type: Article

References (44)

1. Antitumor effect of alkylphosphocholines in different tumor models: Use of liposomal preparations
2. Antineoplastic activity of alkylphosphocholines (APC) in human breast carcinomas in vivo and in vitro: Use of liposomes
3. Pharmocokinetics of sterically stabilized hexadecylphosphocholine liposomes versus conventional liposomes and free hexadecylphosphocholine in tumor-free and human breast carcinoma bearing mice
4. Hexadecylphosphocholine: Preclinical and first clinical results of a new antitumor drug
5. Topical applied miltefosin (hexadecylphosphocholine) in cutaneous relapses and/or skin metastasized breast cancer: A French multicentric study
6. Trial of oral miltefosine for visceral leishmaniasis
7. Topical treatment with hexadecylphosphocholine (Miltex) efficiently reduces parasite burden in experimental cutaneous leishmaniasis
8. PhaseII-study of daily oral miltefosine (hexadecylphosphocholine) in advanced colorectal cancer
9. PhaseII-study of miltefosine (hexadecylphosphocholine) in advanced soft tissue carcinomas of the adult - An EORTC Soft Tissue and Bone Sarcoma Group Study
10. Alkylphosphocholine induced production of nitric oxide and TNFα by U 937 cells
11. Induction of nitric oxide production and tumoricidal properties in murine macrophages by a new synthetic lipopeptide JBT3002 encapsulated in liposomes
12. Influence of hexadecylphosphocholine on the release of tumor necrosis factor and nitroxide from peritoneal macrophages in vitro
13. Effects of antineoplastic phospholipids on parameters of cell differentiation in U 937 cells
14. Effects of hexadecylphosphocholine on protein kinase C and TPA-induced differentiation in HL 60 cells
15. Induction of tumor cell differentiation by alkylphosphocholines: A new approach for in vitro screening
16. Cytotoxic effects of alkylphosphocholines and alkylphosphocholine-liposomes and macrophages on tumor cells
17. Immunmodifying and tumorcytotoxic properties of free and liposomal alkylphosphocholines
18. Stimulation of human hematopoietic progenitor cells by the alkylphosphocholines hexadecylphosphocholine and hexadecyl-N,N,N-trimethyl-hexanolamine
19. Long term human breast carcinoma cell lines of metastatic origin: Preliminary characterization
20. Relative malignant potential of human breast carcinoma cell lines established from pleural effusions and a brain metastasis
21. Antineoplastic activity in vitro of free and liposomal alkylphosphocholines
22. Expression of inflammatory cytokines by murine macrophages activated with a new synthetic lipopeptide JT 3002
23. Suppression of angiogenesis, tumorigenicity and metastasis by human prostate cancer cells engineered to produce interferon β
24. Synergistic activation of recombinant mouse IFNγ and muramyl dipeptide of tumoricidal properties in mouse macrophages
25. Computerized assessment of production of multiple human cytokines at the single cell level using image analysis
26. Inhibition of retinoic acid of type IV collagenolysis and invasion through reconstituted basement membrane by metastatic rat mammary adenocarcinoma cells
27. Effects of antineoplastic ether lipids on model and biological membranes
28. The phospholipid analogue, hexadecylphosphocholine, inhibits protein kinase C in vitro and antagonises phorbol ester-stimulated cell proliferation
29. Hexadecylphosphocholine inhibits translocation of CTP: Choline-phosphate cytidylyltransferase in Madin-Darby canine kidney cells
30. Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues
31. Elevation of leukemic cell intracellular calcium by the ether lipid SRI 62-834
32. Etherlipids-side chain- and polar headgroup-dependent effects on phosphatidylcholine biosynthesis
33. Synthetic alkyl-phospholipid analogues: A new class of antitumor agents
34. Antineoplastic actions of ether lipids related to platelet-activating factor
35. Antitumoral and other biomedical activities of synthetic lysophospholipids
36. Alkylphosphocholines: A new class of membrane-active anticancer agents
37. Activation of mouse peritoneal macrophages by lysophospholipids and ether derivates of neutral lipids and phospholipids
38. Tumor cytotoxicity of human macrophages after incubation with synthetic analogues of 2-lysophosphocholine
39. Differential effects of ether lipids on the activity and secretion of interleukin-1 and interleukin-2
40. Differential uptake of conventional and polyethylene clycol modified alkylphosphocholine-liposomes by J774A.1 murine macrophages
41. Tumour necrosis factor and interferon are selectively cytostatic in vitro for hormone-dependent and hormone-independent human breast cancer cells
42. Tumor necrosis factor-mediated cell lysis in vitro: Relationship to cAMP accumulation and guanine nucleotide-binding proteins
43. Expression of interleukin-6, interleukin-6 receptor, and glycoprotein 130 correlates with good prognoses for patients with breast carcinoma
44. Subcutaneous administration of recombinant glycosylated interleucin 6 in patients with cancer: Pharmacokinetics, pharmacodynamics and immunmodulatory effects