Transformation of bone marrow B-cell progenitors by E2A-HLF requires coexpression of BCL-2

Molecular and Cellular Biology

Volumn 22, Issue 21, 2002, Pages 7678-7687

  Smith, Kevin S ^a   Rhee, Joon Whan ^a   Cleary, Michael L ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 7; PROTEIN BCL 2; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E2A HLF; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL GROWTH; CELL IMMORTALIZATION; CELL LINE; CELL TRANSFORMATION; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HEMATOPOIETIC CELL; LEUKEMIA; LEUKEMOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STEM CELL; TRANSCRIPTION REGULATION;

ANIMALS; B-LYMPHOCYTES; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; BLOTTING, SOUTHERN; BLOTTING, WESTERN; BONE MARROW CELLS; CELL DIVISION; CELL SEPARATION; CELL TRANSFORMATION, NEOPLASTIC; DISEASE PROGRESSION; DNA; DNA-BINDING PROTEINS; FLOW CYTOMETRY; GENOTYPE; INTERLEUKIN-7; LEUKEMIA; METHYLCELLULOSE; MICE; MICE, INBRED BALB C; MODELS, GENETIC; MUTATION; ONCOGENE PROTEINS, FUSION; PHENOTYPE; PROTO-ONCOGENE PROTEINS C-BCL-2; RETROVIRIDAE; STEM CELLS; TIME FACTORS; TRANSGENES; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; MURINAE;

EID: 0036837682     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.21.7678-7688.2002     Document Type: Article

References (37)

1. Carsetti, R. 2000. The development of B cells in the bone marrow is controlled by the balance between cell-autonomous mechanisms and signals from the microenvironment. J. Exp. Med. 191:5-8.
2. Cleary, M. L., S. D. Smith, and J. Sklar. 1986. Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation. Cell 47:19-28.
3. Dedera, D. A., E. K. Waller, D. P. LeBrun, A. Sen-Majumbar, M. E. Stevens, G. S. Barsh, and M. L. Cleary. 1993. Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice. Cell 74:833-843.
4. Drexler, H. G. 1998. Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18, and p19 in human leukemia-lymphoma cells. Leukemia 12:845-859.
5. Eischen, C. M., J. D. Weber, M. F. Roussel, C. J. Sherr, and J. L. Cleveland. 1999. Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis. Genes Dev. 13:2658-2669.
6. Gannon, J. V., R. Greaves, R. Iggo, and D. P. Lane. 1990. Activating mutations in p53 produce a common conformational effect: a monoclonal antibody specific for the mutant form. EMBO J. 9:1595-1602.
7. Hardy, R. R., C. E., Carmack, S. A. Shinton, J. D. Kemp, and K. Hayakawa. 1991. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173:1213-1225.
8. Hawley, R. G., F. H. L. Lieu, A. Z. C. Fong, and T. S. Hawley. 1994. Versatile retroviral vectors for potential use in gene therapy. Gene Ther. 1:136-138.
9. Honda, H., T. Inaba, T. Suzuki, H. Oda, Y. Ebihara, K. Tsuiji, T. Nakahata, T. Ishikawa, Y. Yazaki, and H. Hirai. 1999. Expression of E2A-HLF chimeric protein induced T-cell apoptosis, B-cell maturation arrest, and development of acute lymphoblastic leukemia. Blood 93:2780-2790.
10. Hueber, A. O., and G. I. Evan. 1998. Traps to catch unwary oncogenes. Trends Genet. 14:364-367.
11. Hunger, S. P., K. Ohyashiki, K. Toyama, and M. L. Cleary. 1992. Hlf, a novel hepatic bZIP protein, shows altered DNA binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia. Genes Dev. 6:1608-1620.
12. Hunger, S. P., R. Brown, and M. L. Cleary. 1994. DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF. Mol. Cell. Biol. 14:5986-5996.
13. Ikushima, S., T. Inukai, T. Inaba, S. D. Nimer, J. L. Cleveland, and A. T. Look. 1997. Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes. Proc. Natl. Acad. Sci. USA 94:2609-2614.
14. Inaba, T., W. M. Roberts, L. H. Shapiro, K. W. Jolly, S. C. Raimondi, S. D. Smith, and A. T. Look. 1992. Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. Science 257:531-534.
15. Inaba, T., T. Inukai, T. Yoshihara, H. Seyschab, R. A. Ashmun, C. E. Canman, S. J. Laken, M. B. Kastan, and A. T. Look. 1996. Reversal of apoptosis by the leukemia-associated E2A-HLF chimaeric transcription factor. Nature 382:541-544.
16. Inukai, T., T. Inaba, S. Ikushima, and A. T. Look. 1998. The AD1 and AD2 transactivation domains of E2A are essential for the anti-apoptotic activity of the chimeric oncoprotein E2A-HLF. Mol. Cell. Biol. 18:6035-6043.
17. Inukai, T., A. Inoue, H. Kurosawa, K. Goi, T. Shinjyo, K. Ozawa, M. Mao, T. Inaba, and A. T. Look. 1999. SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein. Mol. Cell 4:343-352.
18. Jacobs, Y., C. Vierra, and C. Nelson. 1993. E2A expression, nuclear localization, and in vivo formation of DNA- and non-DNA-binding species during B-cell development. Mol. Cell. Biol. 13:7321-7333.
19. Jang, S. K., and E. Wimmer. 1990. Cap-independent translation of encephalomyocarditis virus RNA: structural elements of the internal ribosomal entry site and involvement of a cellular 57-kD RNA-binding protein. Genes Dev. 4:1560-1572.
20. ARF. Cell 91:649-659.
21. Lavau, C., J. M. Heard, O. Danos, and A. Dejean. 1996. Retroviral vectors for the transduction of the PML-RARα fusion product of acute promyelocytic leukemia. Exp. Hematol. 24:544-551.
22. LeBien, T. W. 2000. Fates of human B-cell precursors. Blood 96:9-23.
23. Look, A. T. 1997. Oncogenic transcription factors in the human acute leukemias. Science 278:1059-1064.
24. Maloney, K. W., L. McGavran, L. F. Odom, and S. P. Hunger. 1998. Different patterns of homozygous p16INK4A and p15INK4B deletions in childhood acute lymphoblastic leukemias containing distinct E2A translocations. Leukemia 12:1417-1421.
25. McLaughlin, J., E. Chianese, and O. N. Witte. 1989. Alternative forms of the BCR-ABL oncogene have quantitatively different potencies for stimulation of immature lymphoid cells. Mol. Cell. Biol. 9:1866-1874.
26. Ohnishi, H., R. Hanada, K. Horibe, T. Hongo, M. Kawamura, S. Naritaka, F. Bessho, M. Yanagisawa, T. Nobori, S. Yamamori, and Y. Hayashi. 1996. Homozygous deletions of p16/MTS1 and p15/MTS2 genes are frequent in t(1;19)-negative but not in t(1;19)-positive B precursor acute lymphoblastic leukemia in childhood. Leukemia 10:1104-1110.
27. Pear, W., G. Nolan, M. Scott, and D. Baltimore. 1993. Production of high-titer helper-free retroviruses by transient transfection. Proc. Natl. Acad. Sci. USA 90:8392-8396.
28. Randle, D. H., F. Zindy, C. J. Sherr, and M. F. Roussel. 2001. Differential effects of p19(Arf) and p16(Ink4a) loss on senescence of murine bone marrow-derived preB cells and macrophages. Proc. Natl. Acad. Sci. USA 98:9654-9659.
29. Rodenhuis, S., J. L. Bos, R. M. Slater, H. Behrendt, M. van't Veer, and L. A. Smets. 1986. Absence of oncogene amplifications and occasional activation of N-ras in lymphoblastic leukemia of childhood. Blood 67:1698-1704.
30. Rolink, A., and F. Melchers. 1996. B-cell development in the mouse. Immunol. Lett. 54:157-161.
31. Scherr, J., and J. D. Weber. 2000. The ARF/p53 pathway. Curr. Opin. Genet. Dev. 10:94-99.
32. Smith, K. S., Y. Jacobs, C. P. Chang, and M. L. Cleary. 1997. Chimeric oncoprotein E2a-Pbx1 induces apoptosis of hematopoietic cells by a p53-independent mechanism that is suppressed by Bcl-2. Oncogene 14:2917-2926.
33. Smith, K. S., J. W. Rhee, L. Naumovski, and M. L. Cleary. 1999. Disrupted differentiation and oncogenic transformation of lymphoid progenitors in E2A-HLF transgenic mice. Mol. Cell. Biol. 19:4443-4451.
34. Whitlock, C. A., G. F. Tidmarsh, C. Muller-Sieburg, and I. L. Weissman. 1987. Bone marrow stromal cell lines with lymphopoietic activity express high levels of a pre-B neoplasia-associated molecule. Cell 48:1009-1021.
35. Whitlock, C. A., and C. Muller-Sieburg. 1997. Long-term B-lymphoid cultures from murine bone marrow: establishment and cloning by using stromal cell line AC 6.21. Methods Mol. Biol. 75:231-248.
36. Zhou, M., L. Gu, T. C. Abshire, A. Homans, A. L. Billett, A. M. Yeager, and H. W. Findley. 2000. Incidence and prognostic significance of MDM2 oncoprotein overexpression in relapsed childhood acute lymphoblastic leukemia. Leukemia 14:61-67.
37. Zou, X., and K. Calame. 1999. Signaling pathways activated by oncogenic forms of Abl tyrosine kinase. J. Biol. Chem. 274:18141-18144.