Chimeric oncoprotein E2a-Pbx1 induces apoptosis of hematopoietic cells by a p53-independent mechanism that is suppressed by Bcl-2

Oncogene

Volumn 14, Issue 24, 1997, Pages 2917-2926

  Smith, Kevin S ^a   Jacobs, Yakop ^a   Chang, Ching Pin ^a   Cleary, Michael L ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Homeodomain; Inducible oncoprotein; Translocation

Indexed keywords

CHIMERIC PROTEIN; DNA BINDING PROTEIN; HOMEODOMAIN PROTEIN; ONCOPROTEIN; PROTEIN BCL 2; PROTEIN P53; TRANSCRIPTION FACTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CHROMOSOME TRANSLOCATION 1; CHROMOSOME TRANSLOCATION 19; CONTROLLED STUDY; FIBROBLAST; GENE INDUCTION; HEMATOPOIETIC CELL; NONHUMAN; PRE B LYMPHOCYTE; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; APOPTOSIS; B-LYMPHOCYTES; CELL CYCLE; CELL LINE; FIBROBLASTS; HEMATOPOIETIC STEM CELLS; HL-60 CELLS; HOMEODOMAIN PROTEINS; HUMANS; ONCOGENE PROTEINS, FUSION; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RECOMBINANT FUSION PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA;

EID: 0030849122     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1201249     Document Type: Article

References (44)

1. Aronheim A, Shiran R, Rosen A and Walker MD. (1993). Proc. Natl. Acad. Sci. USA, 90, 8063-8067.
2. Chang C-P, Brocchieri L, Shen W-F, Largman C and Cleary ML. (1996). Mol. Cell. Biol., 16, 1734-1745.
3. Chang C-P, Shen W-F, Rozenfeld S, Lawrence HJ, Largman C and Cleary ML. (1995). Genes Dev., 9, 663-674.
4. Chang C-P, DeVivo I and Cleary ML. (1997). Mol. Cell. Biol., In press.
5. Cleary ML. (1991). Cell, 66, 619-622.
6. Debbas M and White E. (1993). Genes Dev., 7, 546-554.
7. Dedera DA, Waller EK, Lebrun DP, Sen-Majumdar A, Stevens ME, Barsh GS and Cleary ML. (1993). Cell, 74, 833-843.
8. Ellis R, Yuan J and Horvitz HR. (1991). Ann. Rev. Cell Biol., 7, 663-698.
9. Evan GI, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, Waters CM, Penn LZ and Hancock DC. (1992). Cell, 69, 119-128.
10. Harrington EA, Fanidi A and Evan GI. (1994). Curr. Opin. Genet. Dev., 4, 120-129.
11. Hermeking H and Eick D. (1994). Science, 265, 2091-2093.
12. Hunger SP, Brown R and Cleary ML. (1994). Mol. Cell. Biol., 14, 5986-5996.
13. Hunger SP, Ohyashiki K, Toyama K and Cleary ML. (1992). Genes Dev., 6, 1608-1620.
14. Inaba T, Inukai T, Yoshihara T, Seyschab H, Ashmun RA, Canman CE, Laken SJ, Kastan MB and Look AT. (1996). Nature, 382, 541-544.
15. Inaba T, Shapiro LH, Funabiki T, Sinclair AE, Jones BG, Ashum RA and Look AT. (1994). Mol. Cell. Biol., 14, 3403-3413.
16. Jacobs Y, Vierra C and Nelson C. (1993). Mol. Cell. Biol., 13, 7321-7333.
17. Kadesch T. (1992). Immunol. Today, 13, 31-36.
18. Kamps MP, Murre C, Sun X-H and Baltimore D. (1990). Cell, 60, 547-556.
19. Kamps MP, Look AT and Baltimore D. (1991). Genes Dev., 5, 358-368.
20. Kamps MP, Wright DD and Lu Q. (1996). Oncogene, 12, 19-30.
21. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B and Craig RW. (1991). Cancer Res., 51, 6304-6311.
22. Kaufmann SH, Desnoyers S, Ottaviano Y, Davidson NE and Poirier GG. (1993). Cancer Res., 53, 3976-3985.
23. Kawamura M, Kikuchi A, Kobayashi S, Hanada R, Yamamoto K, Horibe K, Shikano T, Ueda K, Hayashi K, Sekiya T and Hayashi Y. (1995). Blood, 85, 2546-2552.
24. Lebrun DP and Cleary ML. (1994). Oncogene, 9, 1641-1647.
25. Lippke JA, Gu Y, Sarnecki C, Caron PR and Su MS-S. (1996). J. Biol. Chem., 271, 1825-1828.
26. Lowe SW, Ruley HE, Jacks T and Housman DE. (1993). Cell, 74, 957-967.
27. Lu Q, Knoepfler PS, Scheele J, Wright DD and Kamps MP. (1995). Mol. Cell. Biol., 15, 3786-3795.
28. Mann RS and Chan S-K. (1996). Trends Genet., 12, 258-262.
29. Monica K, Galili N, Nourse J, Saltman D and Cleary ML. (1991). Mol. Cell. Biol., 11, 6149-6157.
30. Monica K, Lebrun DP, Dedera DA, Brown R and Cleary ML. (1994). Mol. Cell. Biol., 14, 8304-8314.
31. Nourse J, Mellentin JD, Galili N, Wilkinson J, Stanbridge E, Smith SD and Cleary ML. (1990). Cell, 60, 535-546.
32. Nunez G and Clarke MF. (1994). Trends Cell Biol., 4, 399-403.
33. Peers B, Sharma S, Johnson T, Kamps M and Montminy M. (1995). Mol. Cell. Biol., 15, 7091-7097.
34. Peverali FA, Ramqvist T, Saffrich R, Pepperkok R, Barone MV and Philipson L. (1994). EMBO J., 13, 4291-4301.
35. Phelan ML, Rambaldi I and Featherstone MS. (1995). Mol. Cell. Biol., 15, 3989-3997.
36. Popped H, Bienz M, Studer M, Chan S-K, Aparicio S, Brenner S, Mann RS and Krumlauf R. (1995). Cell, 81, 1031-1042.
37. Quong MW, Massari ME, Swart R and Murre C. (1993). Mol. Cell. Biol., 13, 792-800.
38. Rauskolb C, Peifer M and Wieschaus E. (1993). Cell, 74, 1101-1112.
39. Rauskolb C and Wieschaus E. (1994). EMBO J., 13, 3561-3569.
40. Schlegel J, Peters I, Orrenius S, Miller DK, Thornberry NA, Yamin T-T and Nicholson DW. (1996). J. Biol. Chem., 271, 1841-1844.
41. Shan B and Lee W-H. (1994). Mol. Cell. Biol., 14, 8166-8173.
42. Wagner AJ, Kokontis JM and Hay N. (1994). Genes Dev., 8, 2817-2830.
43. Wolf D and Rotter V. (1985). Proc. Natl. Acad. Sci. USA, 82, 790-794.
44. Zou H and Niswander L. (1996). Science, 272, 738-741.