Cloning of three mouse Unc5 genes and their expression patterns at mid-gestation

Mechanisms of Development

Volumn 118, Issue 1-2, 2002, Pages 191-197

  Engelkamp, Dieter ^a  

^a MAX PLANCK INSTITUTE FOR BRAIN RESEARCH   (Germany)

Author keywords

Blood vessel development; Deleted in colorectal cancer; Eye development; Inner ear development; Limb development; Mammary gland development; Netrin 1; unc 5; Unc5h1; Unc5h2; Unc5h3; Unc5h4

Indexed keywords

MESSENGER RNA; CAENORHABDITIS ELEGANS PROTEIN; CELL SURFACE RECEPTOR; UNC 5 PROTEIN, C ELEGANS; UNC-5 PROTEIN, C ELEGANS;

ANIMAL EXPERIMENT; ARTICLE; BLOOD VESSEL; CAENORHABDITIS; CENTRAL NERVOUS SYSTEM; COLORECTAL CARCINOMA; CONTROLLED STUDY; EMBRYO; EYE; GENE EXPRESSION; GENETIC ANALYSIS; LIMB DEVELOPMENT; MOLECULAR CLONING; MOUSE; MULTIGENE FAMILY; NONHUMAN; ORGANOGENESIS; PREGNANCY; PRIORITY JOURNAL; RETINA; RNA ANALYSIS; SEQUENCE HOMOLOGY; VASCULARIZATION; AMINO ACID SEQUENCE; ANIMAL; BIOSYNTHESIS; CAENORHABDITIS ELEGANS; GENE EXPRESSION REGULATION; GENETICS; IN SITU HYBRIDIZATION; LIMB; METABOLISM; MOLECULAR GENETICS; PHYLOGENY; PRENATAL DEVELOPMENT; PROTEIN TERTIARY STRUCTURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE DISTRIBUTION;

CAENORHABDITIS; CAENORHABDITIS ELEGANS; VERTEBRATA;

AMINO ACID SEQUENCE; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CLONING, MOLECULAR; EXTREMITIES; EYE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IN SITU HYBRIDIZATION; MICE; MOLECULAR SEQUENCE DATA; PHYLOGENY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; TISSUE DISTRIBUTION;

EID: 0036805336     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(02)00248-4     Document Type: Article

References (31)

1. Ackerman S.L., Knowles B.B. Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23. Genomics. 52:1998;205-208.
2. Ackerman S.L., Kozak L.P., Przyborski S.A., Rund L.A., Boyer B.B., Knowles B.B. The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein. Nature. 386:1997;838-842.
3. Barrett C., Guthrie S. Expression patterns of the netrin receptor UNC5H1 among developing motor neurons in the embryonic rat hindbrain. Mech. Dev. 106:2001;163-166.
4. Capdevila J., Belmonte J.C.I. Patterning mechanisms controlling vertebrate limb development. Annu. Rev. Cell Dev. Biol. 17:2001;87-132.
5. Cooper H.M., Armes P., Britto J., Gad J., Wilks A.F. Cloning of the mouse homologue of the deleted in colorectal cancer gene (mDCC) and its expression in the developing mouse embryo. Oncogene. 11:1995;2243-2254.
6. Deiner M.S., Kennedy T.E., Fazeli A., Serafini T., Tessier-Lavigne M., Sretavan D.W. Netrin-1 and DCC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasia. Neuron. 19:1997;575-589.
7. Ellezam B., Selles-Navarro I., Manitt C., Kennedy T.E., McKerracher L. Expression of netrin-1 and its receptors DCC and UNC-5H2 after axotomy and during regeneration of adult rat retinal ganglion cells. Exp. Neurol. 168:2001;105-115.
8. Engelkamp D., Rashbass P., Seawright A., van Heyningen V. Role of Pax6 in development of the cerebellar system. Development. 126:1999;3585-3596.
9. Frohman M.A. Rapid amplification of cDNA ends (RACE): user-friendly cDNA cloning. Amplification. 5:1990;11-15.
10. Hong K.S., Hinck L., Nishiyama M., Poo M.M., Tessier-Lavigne M., Stein E. A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion. Cell. 97:1999;927-941.
11. Johansson K., Torngren M., Wasselius J., Mansson L., Ehinger B. Developmental expression of DCC in the rat retina. Dev. Brain Res. 130:2001;133-138.
12. Keeling S.L., Gad J.M., Cooper H.M. Mouse neogenin, a DCC-like molecule, has four splice variants and is expressed widely in the adult mouse and during embryogenesis. Oncogene. 15:1997;691-700.
13. Keleman K., Dickson B.J. Short- and long-range repulsion by the Drosophila Unc5 netrin receptor. Neuron. 32:2001;605-617.
14. Leonardo E.D., Hinck L., Masu M., Keino-Masu K., Ackerman S.L., Tessier-Lavigne M. Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors. Nature. 386:1997;833-838.
15. Leung-Hagesteijn C., Spence A.M., Stern B.D., Zhou Y., Su M.W., Hedgecock E.M., Culotti J.G. UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans. Cell. 71:1992;289-299.
16. Livesey F.J., Hunt S.P. Netrin and netrin receptor expression in the embryonic mammalian nervous system suggests roles in retinal, striatal, nigral, and cerebellar development. Mol. Cell. Neurosci. 8:1997;417-429.
17. Mailleux A.A., Spencer-Dene B., Dillon C., Ndiaye D., Savona-Baron C., Itoh N., Kato S., Dickson C., Thiery J.P., Bellusci S. Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo. Development. 129:2002;53-60.
18. Merz D.C., Zheng H., Killeen M.T., Krizus A., Culotti J.G. Multiple signaling mechanisms of the UNC-6/netrin receptors UNC-5 and UNC-40/DCC in vivo. Genetics. 158:2001;1071-1080.
19. Petrausch B., Jung M., Leppert C.A., Stuermer C.A.O. Lesion-induced regulation of netrin receptors and modification of netrin-1 expression in the retina of fish and grafted rats. Mol. Cell. Neurosci. 16:2000;350-364.
20. Phippard D.J., WeberHall S.J., Sharpe P.T., Naylor M.S., Jayatalake H., Maas R., Woo I., RobertsClark D., FrancisWest P.H., Liu Y.H., Maxson R., Hill R.E., Dale T.C. Regulation of Msx-1, Msx-2, Bmp-2 and Bmp-4 during foetal and postnatal mammary gland development. Development. 122:1996;2729-2737.
21. Przyborski S.A., Knowles B.B., Ackerman S.L. Embryonic phenotype of Unc5h3 mutant mice suggests chemorepulsion during the formation of the rostral cerebellar boundary. Development. 125:1998;41-50.
22. Püschel A.W. Divergent properties of mouse netrins. Mech. Dev. 83:1999;65-75.
23. Risau W., Flamme I. Vasculogenesis Annu. Rev. Cell Dev. Biol. 11:1995;73-91.
24. Salminen M., Meyer B.I., Bober E., Gruss P. Netrin 1 is required for semicircular canal formation in the mouse inner ear. Development. 127:2000;13-22.
25. Seaman C., Cooper H.M. Netrin-3 protein is localized to the axons of motor, sensory, and sympathetic neurons. Mech. Dev. 101:2001;245-248.
26. Serafini T., Colamarino S.A., Leonardo E.D., Wang H., Beddington R., Skarnes W.C., Tessier-Lavigne M. Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell. 87:1996;1001-1014.
27. Tessier-Lavigne M., Goodman C.S. The molecular biology of axon guidance. Science. 274:1996;1123-1133.
28. Tickle C. Vertebrate limb development. Semin. Cell Dev. Biol. 7:1996;137-143.
29. de la Torre J.R., Hopker V.H., Ming G.L., Poo M.M., Tessier-Lavigne M., Hemmati-Brivanlou A., Holt C.E. Turning of retinal growth cones in a netrin-1 gradient mediated by the netrin receptor DCC. Neuron. 19:1997;1211-1224.
30. Vargesson N., Luria V., Messina I., Erskine L., Laufer E. Expression patterns of Slit and Robo family members during vertebrate limb development. Mech. Dev. 106:2001;175-180.
31. Wang H., Copeland N.G., Gilbert D.J., Jenkins N.A., Tessier-Lavigne M. Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors. J. Neurosci. 19:1999;4938-4947.