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Volumn 4, Issue 12, 1998, Pages 1383-1391

A serine elastase inhibitor reduces inflammation and fibrosis and preserves cardiac function after experimentally-induced murine myocarditis

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; ELASTASE INHIBITOR; UNCLASSIFIED DRUG; ZD 0892;

EID: 0031728050     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/3973     Document Type: Article
Times cited : (68)

References (44)
  • 1
    • 3743097531 scopus 로고
    • Myocarditis and dilated cardiomyopathy: Different stages of same disease? in Contemporary issues in Cardiovascular Pathology
    • Fallon, J.T. Myocarditis and dilated cardiomyopathy: Different stages of same disease? in Contemporary issues in Cardiovascular Pathology. Cardiovasc. Clin. Ser. 18, 155-162 (1987).
    • (1987) Cardiovasc. Clin. Ser. , vol.18 , pp. 155-162
    • Fallon, J.T.1
  • 3
    • 0027137594 scopus 로고
    • Viral myocarditis: Changing concepts in pathogenesis and implications in diagnosis and treatment
    • Liu, P., Wang E.E.L. & Sole, M. Viral myocarditis: Changing concepts in pathogenesis and implications in diagnosis and treatment. Cardiovasc. Pathol. 2, 247-257 (1993).
    • (1993) Cardiovasc. Pathol. , vol.2 , pp. 247-257
    • Liu, P.1    Wang, E.E.L.2    Sole, M.3
  • 4
    • 0017817836 scopus 로고
    • The prevalence of encephalomyocarditis virus neutralizing antibodies among various human populations
    • Tesh, R.B. The prevalence of encephalomyocarditis virus neutralizing antibodies among various human populations. Am. J. Trop. Med. Hyg. 27, 144-149 (1978).
    • (1978) Am. J. Trop. Med. Hyg. , vol.27 , pp. 144-149
    • Tesh, R.B.1
  • 5
    • 0025135188 scopus 로고
    • Circulating heart-reactive antibodies in patients with myocarditis and cardiomyopathy
    • Neumann D.A., Burik, K.L., Rose, N.R. & Herskowitz, A. Circulating heart-reactive antibodies in patients with myocarditis and cardiomyopathy. J. Am. Coll. Cardiol. 16, 839-846 (1990).
    • (1990) J. Am. Coll. Cardiol. , vol.16 , pp. 839-846
    • Neumann, D.A.1    Burik, K.L.2    Rose, N.R.3    Herskowitz, A.4
  • 6
    • 0019970881 scopus 로고
    • An animal model of congestive (dilated) cardiomyopathy: Dilatation and hypertrophy of the heart in the chronic stage in DBA/2 mice with myocarditis caused by encephalomyocarditis virus
    • Matsumori, A. & Kawai, C. An animal model of congestive (dilated) cardiomyopathy: Dilatation and hypertrophy of the heart in the chronic stage in DBA/2 mice with myocarditis caused by encephalomyocarditis virus. Circulation 66, 355-360 (1982).
    • (1982) Circulation , vol.66 , pp. 355-360
    • Matsumori, A.1    Kawai, C.2
  • 7
    • 0025073613 scopus 로고
    • In vivo significance of T cells in the development of Coxsackievirus B3 myocarditis in mice. Immature but antigen-specific T cells aggravate cardiac injury
    • Kishimoto, C. & Abelmann, W.H. In vivo significance of T cells in the development of Coxsackievirus B3 myocarditis in mice. Immature but antigen-specific T cells aggravate cardiac injury. Circ. Res. 67, 589-598 (1990).
    • (1990) Circ. Res. , vol.67 , pp. 589-598
    • Kishimoto, C.1    Abelmann, W.H.2
  • 8
    • 0029879010 scopus 로고    scopus 로고
    • Depletion of Mac1-positive macrophages protects DBA/2 mice from encephalomyocarditis virus-induced myocarditis and diabetes
    • Hirasawa, K. et al. Depletion of Mac1-positive macrophages protects DBA/2 mice from encephalomyocarditis virus-induced myocarditis and diabetes. J. Gen. Virol. 77, 737-741 (1996).
    • (1996) J. Gen. Virol. , vol.77 , pp. 737-741
    • Hirasawa, K.1
  • 9
    • 0026535401 scopus 로고
    • Interleukin 1 or tumor necrosis factor can promote coxsackie B3-induced myocarditis in resistant B10.A mice
    • Lane, J.R., Neumann, D.A., Lafond-Walker, A., Herskowitz, A. & Rose, N.R. Interleukin 1 or tumor necrosis factor can promote coxsackie B3-induced myocarditis in resistant B10.A mice. J. Exp. Med. 175, 1123-1129 (1992).
    • (1992) J. Exp. Med. , vol.175 , pp. 1123-1129
    • Lane, J.R.1    Neumann, D.A.2    Lafond-Walker, A.3    Herskowitz, A.4    Rose, N.R.5
  • 10
    • 0028047609 scopus 로고
    • Therapeutic effect of anti-tumor necrosis factor-α antibody on the murine model of viral myocarditis induced by encephalomyocarditis virus
    • Yamada, T., Matsumori, A. & Sasayama, S. Therapeutic effect of anti-tumor necrosis factor-α antibody on the murine model of viral myocarditis induced by encephalomyocarditis virus. Circulation 89, 846-851 (1994).
    • (1994) Circulation , vol.89 , pp. 846-851
    • Yamada, T.1    Matsumori, A.2    Sasayama, S.3
  • 11
    • 0029155321 scopus 로고
    • Therapy with immunoglobulin suppresses myocarditis in a murine coxsackievirus B3 model. Antiviral and anti-inflammatory effects
    • Takada, H., Kishimoto, C. & Hiraoka, Y. Therapy with immunoglobulin suppresses myocarditis in a murine coxsackievirus B3 model. Antiviral and anti-inflammatory effects. Circulation 92, 1604-1611 (1995).
    • (1995) Circulation , vol.92 , pp. 1604-1611
    • Takada, H.1    Kishimoto, C.2    Hiraoka, Y.3
  • 13
    • 0024426536 scopus 로고
    • Absence of effects of cyclosporine on myocardial lymphocyte subsets in coxsackievirus B3 myocarditis in the aviremic stage
    • Kishimoto, C. & Abelmann, W.H. Absence of effects of cyclosporine on myocardial lymphocyte subsets in coxsackievirus B3 myocarditis in the aviremic stage. Circ. Res. 65, 934-945 (1989).
    • (1989) Circ. Res. , vol.65 , pp. 934-945
    • Kishimoto, C.1    Abelmann, W.H.2
  • 14
    • 0025088118 scopus 로고
    • Immunosuppression with high doses of cyclophosphamide reduces the severity of myocarditis but increases mortality in murine coxsackievirus B3 myocarditis
    • Kishimoto C., Thorp, K.A. & Abelmann, W.H. Immunosuppression with high doses of cyclophosphamide reduces the severity of myocarditis but increases mortality in murine coxsackievirus B3 myocarditis. Circulation 82, 982-989 (1990).
    • (1990) Circulation , vol.82 , pp. 982-989
    • Kishimoto, C.1    Thorp, K.A.2    Abelmann, W.H.3
  • 15
    • 0024403898 scopus 로고
    • Coronary microvascular narrowing in acute murine coxsackie B3 myocarditis
    • Silver, M.A. & Kowalczyk, D. Coronary microvascular narrowing in acute murine coxsackie B3 myocarditis. Am. Heart J. 118, 173-174 (1989).
    • (1989) Am. Heart J. , vol.118 , pp. 173-174
    • Silver, M.A.1    Kowalczyk, D.2
  • 16
    • 0019979507 scopus 로고
    • Microvascular spasm in the cardiomyopathic Syrian hamster: A preventable cause of focal myocardial necrosis
    • Factor, S.M., Minase, T., Cho, S., Dominitz, R. & Sonnenblick, E.H. Microvascular spasm in the cardiomyopathic Syrian hamster: A preventable cause of focal myocardial necrosis. Circulation 66, 342-354 (1982).
    • (1982) Circulation , vol.66 , pp. 342-354
    • Factor, S.M.1    Minase, T.2    Cho, S.3    Dominitz, R.4    Sonnenblick, E.H.5
  • 17
    • 0026469892 scopus 로고
    • Verapamil ameliorates the clinical and pathological course of murine myocarditis
    • Dong, R., Liu, P., Wee, L., Butany, J. & Sole, M.J. Verapamil ameliorates the clinical and pathological course of murine myocarditis. J. Clin. Invest. 90, 2022-2030 (1992).
    • (1992) J. Clin. Invest. , vol.90 , pp. 2022-2030
    • Dong, R.1    Liu, P.2    Wee, L.3    Butany, J.4    Sole, M.J.5
  • 18
    • 0027078575 scopus 로고
    • The effect of alpha 1 -blocker, bunazosin on a murine model of congestive heart failure induced by viral myocarditis
    • Yamada, T., Matsumori, A., Okada, I., Tominaga, M. & Kawai, C. The effect of alpha 1 -blocker, bunazosin on a murine model of congestive heart failure induced by viral myocarditis. Jap. Circ. J. 56, 1138-1145 (1992).
    • (1992) Jap. Circ. J. , vol.56 , pp. 1138-1145
    • Yamada, T.1    Matsumori, A.2    Okada, I.3    Tominaga, M.4    Kawai, C.5
  • 19
    • 0025893178 scopus 로고
    • Beta-blocker treatment of dilated cardiomyopathy. Beneficial effect of carteolol in mice
    • Tominaga, M., Matsumori, A., Okada, I., Yamada, T. & Kawai, C. Beta-blocker treatment of dilated cardiomyopathy. Beneficial effect of carteolol in mice. Circulation 83, 2021-2028 (1991).
    • (1991) Circulation , vol.83 , pp. 2021-2028
    • Tominaga, M.1    Matsumori, A.2    Okada, I.3    Yamada, T.4    Kawai, C.5
  • 20
    • 0025344209 scopus 로고
    • Beneficial effects of captopril in acute coxsackievirus B3 murine myocarditis
    • Rezkalla, S., Kloner, R.A., Khatib, C. & Khatib, R. Beneficial effects of captopril in acute coxsackievirus B3 murine myocarditis. Circulation 81, 1039-1046 (1990).
    • (1990) Circulation , vol.81 , pp. 1039-1046
    • Rezkalla, S.1    Kloner, R.A.2    Khatib, C.3    Khatib, R.4
  • 22
    • 0024524974 scopus 로고
    • Disruption of the subendothelial basement membrane during neutrophil diapedesis in an in vitro construct of a blood vessel wall
    • Huber, A.R. & Weiss, S.J. Disruption of the subendothelial basement membrane during neutrophil diapedesis in an in vitro construct of a blood vessel wall. J. Clin. Invest. 83, 1122-1136 (1989).
    • (1989) J. Clin. Invest. , vol.83 , pp. 1122-1136
    • Huber, A.R.1    Weiss, S.J.2
  • 23
    • 0024999177 scopus 로고
    • Reperfusion-induced leukocyte infiltration: Role of elastase
    • Zimmerman, B.J. & Granger, D.N. Reperfusion-induced leukocyte infiltration: Role of elastase. Am. J. Physiol. 259, H390-H394 (1990).
    • (1990) Am. J. Physiol. , vol.259
    • Zimmerman, B.J.1    Granger, D.N.2
  • 24
    • 0025329933 scopus 로고
    • Increased neutrophil elastase release in unstable angina pectoris and acute myocardial infarction
    • Dinerman, J.L. et al. Increased neutrophil elastase release in unstable angina pectoris and acute myocardial infarction. J. Am. Coll. Cardiol. 15, 1559-1563 (1990).
    • (1990) J. Am. Coll. Cardiol. , vol.15 , pp. 1559-1563
    • Dinerman, J.L.1
  • 25
    • 0026056556 scopus 로고
    • Leukocyte elastase inhibition and t-PA-induced coronary artery thrombolysis in dogs: Beneficial effects on myocardial histology
    • Nicolini, F.A. et al. Leukocyte elastase inhibition and t-PA-induced coronary artery thrombolysis in dogs: Beneficial effects on myocardial histology. Am. Heart J. 122, 1245-1251 (1991).
    • (1991) Am. Heart J. , vol.122 , pp. 1245-1251
    • Nicolini, F.A.1
  • 26
    • 0031044218 scopus 로고    scopus 로고
    • Inhibition of elastase improves myocardial function after repetitive ischemia and myocardial infarction in the rat heart
    • Tiefenbacher, C.P., Niroomand, M.E.F., Tillmanns, S.B.H. & Kübler, R.Z.W. Inhibition of elastase improves myocardial function after repetitive ischemia and myocardial infarction in the rat heart. Eur. J. Physiol. 433, 563-570 (1997).
    • (1997) Eur. J. Physiol. , vol.433 , pp. 563-570
    • Tiefenbacher, C.P.1    Niroomand, M.E.F.2    Tillmanns, S.B.H.3    Kübler, R.Z.W.4
  • 27
    • 0030000087 scopus 로고    scopus 로고
    • Elafin, a serine elastase inhibitor, attenuates post-cardiac transplant coronary arteriopathy and reduces myocardial necrosis in rabbits after heterotopic cardiac transplantation
    • Cowan, B. et al. Elafin, a serine elastase inhibitor, attenuates post-cardiac transplant coronary arteriopathy and reduces myocardial necrosis in rabbits after heterotopic cardiac transplantation. J. Clin. Invest. 97, 2452-2468 (1996).
    • (1996) J. Clin. Invest. , vol.97 , pp. 2452-2468
    • Cowan, B.1
  • 28
    • 0028338777 scopus 로고
    • Post-cardiac transplant arteriopathy in piglets is associated with fragmentation of elastin and increased activity of a serine elastase
    • Oho, S. & Rabinovitch, M. Post-cardiac transplant arteriopathy in piglets is associated with fragmentation of elastin and increased activity of a serine elastase. Am. J. Pathol. 145, 202-210 (1994).
    • (1994) Am. J. Pathol. , vol.145 , pp. 202-210
    • Oho, S.1    Rabinovitch, M.2
  • 29
    • 0028053661 scopus 로고
    • Role of neutrophil depletion and elastase inhibition in modifying skeletal muscle reperfusion injury
    • Crinnion, J.N., Homer-Vanniasinkam, S., Hatton, R., Parkin, S.M. & Gough, M.J. Role of neutrophil depletion and elastase inhibition in modifying skeletal muscle reperfusion injury. Cardiovasc. Surg. 2, 749-753 (1994).
    • (1994) Cardiovasc. Surg. , vol.2 , pp. 749-753
    • Crinnion, J.N.1    Homer-Vanniasinkam, S.2    Hatton, R.3    Parkin, S.M.4    Gough, M.J.5
  • 30
    • 15144355533 scopus 로고    scopus 로고
    • Discovery and biological activity of orally active peptidyl trifluoromethyl ketone inhibitors of human neutrophil elastase
    • Edwards, P.D. et al. Discovery and biological activity of orally active peptidyl trifluoromethyl ketone inhibitors of human neutrophil elastase. J. Med. Chem. 40, 1876-1885 (1997).
    • (1997) J. Med. Chem. , vol.40 , pp. 1876-1885
    • Edwards, P.D.1
  • 31
    • 9844256449 scopus 로고    scopus 로고
    • Orally active trifluoromethyl ketone inhibitors of human leukocyte elastase
    • Veale, C.A. et al. Orally active trifluoromethyl ketone inhibitors of human leukocyte elastase. J. Med. Chem. 40, 3173-3181 (1997).
    • (1997) J. Med. Chem. , vol.40 , pp. 3173-3181
    • Veale, C.A.1
  • 32
    • 0027248217 scopus 로고
    • Inhibition of proteolytic activity of poliovirus and rhinovirus 2A proteinases by elastase-specific inhibitors
    • Molla, A., Hellen, C.U.T. & Wimmer, E. Inhibition of proteolytic activity of poliovirus and rhinovirus 2A proteinases by elastase-specific inhibitors. J. Virol. 67, 4688-4695 (1993).
    • (1993) J. Virol. , vol.67 , pp. 4688-4695
    • Molla, A.1    Hellen, C.U.T.2    Wimmer, E.3
  • 33
    • 0025910160 scopus 로고
    • Expression of perform in infiltrating cells in murine myocarditis caused by coxsackievirus B3
    • Seko, Y., Shinkai, Y. & Kawasaki, A. Expression of perform in infiltrating cells in murine myocarditis caused by coxsackievirus B3. Circulation 84, 788-795 (1991).
    • (1991) Circulation , vol.84 , pp. 788-795
    • Seko, Y.1    Shinkai, Y.2    Kawasaki, A.3
  • 34
    • 0025306577 scopus 로고
    • Novel organ-specific circulating cardiac autoantibodies in dilated cardiomyopathy
    • Caforio A.L.P. et al. Novel organ-specific circulating cardiac autoantibodies in dilated cardiomyopathy. J. Am. Coll. Cardiol. 15, 1527-1534 (1990).
    • (1990) J. Am. Coll. Cardiol. , vol.15 , pp. 1527-1534
    • Caforio, A.L.P.1
  • 35
    • 0024430531 scopus 로고
    • Elastase and cathepsin G of human monocytes. Quantification of cellular content, release in response to stimuli, and heterogeneity in elastase-mediated proteolytic activity
    • Campbell, E.J., Silverman, E.K. & Campell, M.A. Elastase and cathepsin G of human monocytes. Quantification of cellular content, release in response to stimuli, and heterogeneity in elastase-mediated proteolytic activity. J. Immunol. 143, 2961-2968 (1989).
    • (1989) J. Immunol. , vol.143 , pp. 2961-2968
    • Campbell, E.J.1    Silverman, E.K.2    Campell, M.A.3
  • 36
    • 0020065395 scopus 로고
    • Elastase of U-937 monocyte-like cells. Comparisons with elastases derived from human monocytes and neutrophils and murine macrophage-like cells
    • Senior, R.M. et al. Elastase of U-937 monocyte-like cells. Comparisons with elastases derived from human monocytes and neutrophils and murine macrophage-like cells. J. Clin. Invest. 69, 384-393 (1982).
    • (1982) J. Clin. Invest. , vol.69 , pp. 384-393
    • Senior, R.M.1
  • 37
    • 0024291666 scopus 로고
    • Cytotoxic T lymphocyte mediated cytolysis
    • Tschopp, J. & Jogeneel, C.V. Cytotoxic T lymphocyte mediated cytolysis. Biochemistry 27, 2641-2646 (1988).
    • (1988) Biochemistry , vol.27 , pp. 2641-2646
    • Tschopp, J.1    Jogeneel, C.V.2
  • 38
    • 0029868471 scopus 로고    scopus 로고
    • Exogenous leukocyte and endogenous elastases can mediate mitogenic activity in pulmonary artery smooth muscle cells by release of extracellular matrix-bound basic fibroblast growth factor
    • Thompson, K. & Rabinovitch, M. Exogenous leukocyte and endogenous elastases can mediate mitogenic activity in pulmonary artery smooth muscle cells by release of extracellular matrix-bound basic fibroblast growth factor. J. Cell. Physiol. 166, 495-505 (1996).
    • (1996) J. Cell. Physiol. , vol.166 , pp. 495-505
    • Thompson, K.1    Rabinovitch, M.2
  • 39
    • 0028362088 scopus 로고
    • The induction of 72-kD gelatinase in T cells upon adhesion to endothelial cells is VCAM-1 dependent
    • Romanic, A.M. & Madri, J.A. The induction of 72-kD gelatinase in T cells upon adhesion to endothelial cells is VCAM-1 dependent. J. Cell Biol. 125, 1165-1178 (1994).
    • (1994) J. Cell Biol. , vol.125 , pp. 1165-1178
    • Romanic, A.M.1    Madri, J.A.2
  • 40
    • 0029553690 scopus 로고
    • Effects of synthesized elastin peptides on human leukocytes
    • Hauck, M. et al. Effects of synthesized elastin peptides on human leukocytes. Biochem. Mol. Biol. Int. 37, 45-55 (1995).
    • (1995) Biochem. Mol. Biol. Int. , vol.37 , pp. 45-55
    • Hauck, M.1
  • 41
    • 0022411604 scopus 로고
    • Enhancement of recovery of myocardial function by oxygen free-radical scavengers after reversible regional ischemia
    • Myers, M.L., Bolli, R., Lekick, R.F., Hartley, C.J. & Roberts, R. Enhancement of recovery of myocardial function by oxygen free-radical scavengers after reversible regional ischemia. Circulation 72, 915-921 (1985).
    • (1985) Circulation , vol.72 , pp. 915-921
    • Myers, M.L.1    Bolli, R.2    Lekick, R.F.3    Hartley, C.J.4    Roberts, R.5
  • 42
    • 0026639508 scopus 로고
    • Evaluation of the effects of low molecular weight heparin on inflammation and collagen deposition in chronic coxsackievirus B3-induced myocarditis in A/J mice
    • Frizelle, S., Schwarz, J., Huber, S.A. & Leslie, K. Evaluation of the effects of low molecular weight heparin on inflammation and collagen deposition in chronic coxsackievirus B3-induced myocarditis in A/J mice. Am. J. Pathol. 141, 203-209 (1992).
    • (1992) Am. J. Pathol. , vol.141 , pp. 203-209
    • Frizelle, S.1    Schwarz, J.2    Huber, S.A.3    Leslie, K.4
  • 43
    • 0020051148 scopus 로고
    • Measurement of cutaneous inflammation: Estimation of neutrophil content with an enzyme marker
    • Bradley, P.P., Priebat, D.A., Christensen, R.D., & Rothstein, C. Measurement of cutaneous inflammation: Estimation of neutrophil content with an enzyme marker. J. Invest. Dermatol. 78, 206-209 (1982).
    • (1982) J. Invest. Dermatol. , vol.78 , pp. 206-209
    • Bradley, P.P.1    Priebat, D.A.2    Christensen, R.D.3    Rothstein, C.4
  • 44
    • 0021722459 scopus 로고
    • Characterization of collagen from normal human sclera
    • Keeley, F.W., Morin, J.D. & Vessely, S. Characterization of collagen from normal human sclera. Exp. Eye Res. 39, 533-542 (1984).
    • (1984) Exp. Eye Res. , vol.39 , pp. 533-542
    • Keeley, F.W.1    Morin, J.D.2    Vessely, S.3


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