Steroid imprinting and modulation of sexual dimorphism in the luteinizing hormone-releasing hormone neuronal system

Cellular and Molecular Neurobiology

Volumn 16, Issue 2, 1996, Pages 129-141

  López, Francisco José ^a   Merchenthaler, István ^a   Liposits, Zsolts ^a   Negro Vilar, Andrés ^a  

^a WYETH AYERST RESEARCH   (United States)

Author keywords

Estrogen; Galanin; Luteinizing hormone releasing hormone; Sexual dimorphism

Indexed keywords

GALANIN; GONADORELIN;

CELL IMMORTALIZATION; GENE EXPRESSION; GONADOTROPIN RELEASE; HORMONAL REGULATION; MENSTRUAL CYCLE; NERVE CELL NETWORK; NEUROSECRETORY CELL; NONHUMAN; OVULATION; PRIORITY JOURNAL; REPRODUCTION; REVIEW; SEX DIFFERENCE; STEROID METABOLISM;

ANIMALS; FEMALE; GONADOTROPIN-RELEASING HORMONE; MALE; NEURONS; NEUROSECRETORY SYSTEMS; SEX CHARACTERISTICS; STEROIDS;

EID: 0030011810     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02088172     Document Type: Article

References (25)

1. Coen, C. W., Montagnese, C., and Opacka-Juffry, J. (1990). Coexistence of gonadolrophin-releasing hormone and galanin: Immunohistochemical and functional studies. J. Neuroendocrinol. 2:107-111.
2. Hasel, K. W., and Sutcliffe, J. G. (1990). Nucleotide sequence of a cDNA coding for mouse cyclophilin. Nucleic Acids Res. 18:4019.
3. Hsu, H. K., Chen, F. N., and Peng, M. T. (1980). Some characteristics of the darkly stained area of the medial preoptic area of rats. Neuroendocrinology 31:327-330.
4. Jacobson, C. D., Shryne, J. E., Shapiro, F., and Gorski, R. A. (1980). Ontogeny of the sexually dimorphic nucleus of the preoptic area. J. Comp. Neurol. 193:541-548.
5. Kaplan, L. M., Gabriel, S. M., Koenig, J. I., Sunday, M. E., Spindel, E. R., Martin, J. B., and Chin, W. W. (1988). Galanin is an estrogen-inducible, secretory product of the rat anterior pituitary. Proc. Natl. Acad. Sci. USA 85:7408-7412.
6. Liposits, Z., Merchenthaler, I., Wetsel, W. C., Reid, J. J., Mellon, P., Weiner, R. J., and Negro-Vilar, A. (1991). Morphological characterization of immortalized hypothalamic neurons synthesizing luteinizing hormone-releasing hormone. Endocrinology 129:1575-1583.
7. Liposits, Z., Reid, J. J., Negro-Vilar, A., and Merchenthaler, I. (1995). Sexual dimorphism in copackaging of luteinizing hormone-releasing hormone and galanin into neurosecretory vesicles of hypophysiotropic neurons: Estrogen dependency. Endocrinology 136:1987-1992.
8. López, F. J., Merchenthaler, I., Ching, M., Wisniewski, M. G., and Negro-Vilar, A. (1991). Galanin: A hypothalamic hypophysiotropic hormone modulating reproductive functions. Proc. Natl. Acad. Sci. USA 88:4508-4512.
9. López, F. J., Meade, E. H., Jr., and Negro-Vilar, A. (1993). Endogenous galanin modulates the gonadotropin and prolactin preovulatory surge in the rat. Endocrinology 132:795-800.
10. Marks, D. L., Wiemann, J. N., Burton, K. A., Lent, K. L., Clifton, D. K., and Steiner, R. A. (1992). Simultaneous visualization of two cellular mRNA species in individual neurons by the use of a new double in situ visualization method. Mol. Cell. Neurosci. 3:395-405.
11. Mellon, P. L., Windle, J. J., Goldsmith, P. C., Padula, C. A., Roberts, J. L., and Weiner, R. I. (1990). Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. Neuron 5:1-10.
12. Merchenthaler, I., López, F. J., and Negro-Vilar, A. (1990). Colocalization of galanin and luteinizing hormone-releasing hormone in a subset of preoptic hypothalamic neurons: anatomical and functional correlates. Proc. Natl. Acad. Sci. USA 87:6326-6330.
13. Merchenthaler, I., López, F. J., Lennard, D. E., and Negro-Vilar, A. (1991). Sexual differences in the distribution of neurons coexpressing galanin and luteinizing hormone-releasing hormone in the rat brain. Endocrinology 129:1977-1986.
14. Merchenthaler, I., Lennard, D. E., López, F. J., and Negro-Vilar, A. (1993a). Neonatal imprinting predetermines the sexually dimorphic, estrogen-dependent expression of galanin in luteinizing hormone-releasing hormone neurons. Proc. Natl. Acad. Sci. USA 90:10479-10483.
15. Merchenthaler, I., López, F. J., and Negro-Vilar, A. (1993b). Anatomy and physiology of central galanin-containing pathways. Prog. Neurobiol. 49:711-769.
16. Moretto, M., López, F. J., and Negro-Vilar, A. (1993). Endothelin-3 stimulates luteinizing hormone-releasing hormone (LHRH) secretion from LHRH neurons by a prostaglandin-dependent mechanism. Endocrinology 132:789-794.
17. Poletti, A., Melcangi Cosimo, R., Negri-Cesi, P., Maggi, R., and Martini, L. (1994). Steroid binding and metabolism in the luteinizing hormone-releasing hormone-producing neuronal cell line GT 1-1. Endocrinology 135:2623-2628.
18. Reisert, I., and Pilgrim, C. (1991). Sexual differentiation of monoaminergic neurons - genetic or epigenetic? Trends Neurosci. 14:468-473.
19. Sahu, A., Xu, B., and Kalra, S. P. (1994). Role of galanin in stimulation of pituitary luteinizing hormone secretion as revealed by a specific receptor antagonist galantide. Endocrinology 134:529-536.
20. Schott, D. R., Schyamala, G., Scheneider, W., and Parry, G. (1991). Molecular cloning, sequence analyses, and expression of complementary DNA encoding murine progesterone receptor. Biochemistry 30:7014-7020.
21. Shivers, B. D., Harlan, R. E., Morrell, J. I., and Pfaff, D. W. (1983). Absence of oestradiol concentration in cell nuclei of LHRH-immunoreactive neurones. Nature 304:345-347.
22. Tatemoto, K., Rökaeus, A., Jörwall, H., McDonald, T. J., and Mutt, V. (1983). Galanin - a novel biologically active peptide from porcine intestine. FEBS Lett. 164:124-128.
23. Watson, R. E., Langub, M. C., and Landis, J. W. (1992). Further evidence that most luteinizing hormone-releasing hormone neurons are not directly estrogen-responsive. Simultaneous localisation of luteinizing hormone-releasing hormone and estrogen receptor immunoreactivity. J. Neuroendocrinol. 4:311-318.
24. Wetsel, W. C., Mellon, P. L., Weiner, R. I., and Negro-Vilar, A. (1991). Metabolism of pro-luteinizing hormone-releasing hormone in immortalized hypothalamic neurons. Endocrinology 129:1584-1595.
25. White, R., Lees, J. A., Needham, M., Ham, J., and Parker, M. (1987). Structural organization and expression of the mouse estrogen receptor. Mol. Endocrinol. 1:735-744.