IL-5 production by bronchoalveolar lavage and peripheral blood mononuclear cells in asthma and atopy

European Respiratory Journal

Volumn 10, Issue 3, 1997, Pages 624-632

  Tang, C ^a,c   Rolland, J M ^b   Ward, C ^a,b   Quan, B ^c   Walters, E H ^a  

^a ALFRED HOSPITAL   (Australia)

^b MONASH UNIVERSITY MEDICAL SCHOOL   (Australia)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

allergen; asthma; atopy; cytokines; interleukin 5; lymphocytes

Indexed keywords

ALLERGEN; INTERLEUKIN 5;

ADULT; ARTICLE; ASTHMA; ATOPY; CELL INTERACTION; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOREACTIVITY; LUNG LAVAGE; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL;

ADULT; ALLERGENS; ANIMALS; ASTHMA; BRONCHIAL PROVOCATION TESTS; BRONCHOALVEOLAR LAVAGE FLUID; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; EOSINOPHILS; FEMALE; FLOW CYTOMETRY; HUMANS; HYPERSENSITIVITY, IMMEDIATE; INTERFERON TYPE II; INTERLEUKIN-5; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MALE; MITES; PULMONARY EOSINOPHILIA;

EID: 0031041428     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Azzawa M, Bradley B, Jeffery PK, et al. Identification of activated T-lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma. Am Rev Respir Dis 1990; 142: 1410-1413.
2. Bradley BL, Azzawi M, Assoufi B, et al. Eosinophils, T-lymphocytes, mast cells, neutrophils and macrophages in bronchial biopsies from atopic asthmatics: comparison with atopic nonasthmatic and normal controls and relationship to bronchial hyperresponsiveness. J Allergy Clin Immunol 1991; 88: 661-674.
3. Bentley AM, Menz G, Storz C, et al. Identification of T-lymphocytes, macrophages and activated eosinophils in the bronchial mucosa in intrinsic asthma: relationship to symptoms and bronchial responsiveness. Am Rev Respir Dis 1992; 146: 500-506.
4. Hamid Q, Barkans J, Robinson DS, Durham SR, Kay AB. Co-expression of CD25 and CD3 in atopic allergy and asthma. Immunology 1992; 75: 659-663.
5. Wilson J, Djukanovic WR, Howarth PH, Holgate ST. Lymphocyte activation in bronchoalveolar lavage and peripheral blood in atopic asthma. Am Rev Respir Dis 1992; 145: 958-960.
6. Kay AB. "Helper" (CD4+) T-cells and eosinophils in allergy and asthma. Am Rev Respir Dis 1992; 145: S22-S26.
7. Gleich GJ. The eosinophil and bronchial asthma: current understanding. J Allergy Clin Immunol 1990; 85: 422-436.
8. Kay AB. Asthma and inflammation. J Allergy Clin Immunol 1991; 87: 893-910.
9. Clutterbuck EJ, Hirst EMA, Sanderson CJ. Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparison and interaction with IL-1, IL-3, IL-6 and GM-CSF. Blood 1989; 73: 1504-1512.
10. Yamaguchi Y, Hayashi Y, et al. Highly purified murine interleukin-5 (IL-5) stimulates eosinophil function and prolongs in vitro survival. J Exp Med 1988; 167: 1737-1742.
11. Lopez AF, Sanderson CJ, Gamble JR, Campbell HD, Young IJ, Vadas MA. Recombinant human interleukin-5 is a selective activator of human eosinophil function. J Exp Med 1988; 167: 219-224.
12. Fujisawa T, Abu-Ghazaleh R, Kita H, Sanderson CJ, Gleich GJ. Regulatory effect of cytokines on eosinophil degranulation. J Immunol 1990; 144: 642-646.
13. Walker C, Virchow JC, Bruijnzeel PLB, Blaser K. T-cell subsets and their soluble products regulate eosinophilia in allergic and nonallergic asthma. J Immunol 1991; 146: 1829-1835.
14. Walker C, Bauer W, Braun RK, Menz G, et al. Activated T-cells and cytokines in bronchoalveolar lavages from patients with various lung diseases associated with eosinophilia Am J Respir Crit Care Med 1994; 150: 1038-1048.
15. Walker, C, Bode E, Boer L, Hansel TT, Blaser K, Virchow JC. Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and BAL. Am Rev Respir Dis 1992; 146: 109-115.
16. Doi S, Gemou-Engesaeth V, Kay AB, Corrigan CJ. Polymerase chain reaction quantification of cytokine messenger RNA expression in peripheral blood mononuclear cells of patients with acute exacerbation of asthma: effect of glucocorticoid therapy. Clin Exp Allergy 1994; 24: 854-867.
17. Corrigan CJ, Hamid Q, North J, et al. Peripheral blood CD4 but not CD8 T-lymphocytes in patients with exacerbation of asthma transcribe and translate messenger RNA encoding cytokines which prolong eosinophil survival in the context of a Th2-type pattern: effect of glucocorticoid therapy. Am J Respir Cell Mol Biol 1995; 12: 567-578.
18. Hamid Q, Azziwa M, Ying S, el at. Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma. J Clin Invest 1991; 87: 1541-1546.
19. Wulsh GM, Hartnell A, Wardlaw AJ, Kurihara K, Sanderson CJ, Kay AB. IL-5 enhances the in vitro adhesion of human eosinophils, but not neutrophils, in a leucocyte integrity (CD11/18)-dependent manner. Immunology 1990; 71: 258-265.
20. Ohnishi T, Sur S, Collins DS, Fish JE, Gleich GJ, Peters SP. Eosinophil survival activity identified as interleukin-5 is associated with eosinophil recruitment and degranulation and lung injury twenty four hours after segmental antigen lung challenge. J Allergy Clin Immunol 1993; 92: 607-615.
21. Ohnishi T, Kita H, Weiler D, et al. IL-5 is the predominant eosinophil-active cytokine in the antigen-induced pulmonary late-phase reaction. Am Rev Respir Dis 1993; 147: 901-907.
22. Kay AB, Ying S, Varney V, et al. Messenger RNA expression of the cytokine gene cluster, IL-3, IL-4, IL-5 and GM-CSF, in allergen-induced late-phase reactions in atopic subjects. J Exp Med 1991; 173: 775-778.
23. Durham S, Ying RS, Varney VA, et al. Cytokine messenger RNA expression for IL-3, IL-4, IL-5 and granulocyte/macrophage colony-stimulating factor in the nasal mucosa after local allergen provocation: relationship to tissue eosinophilia. J Immunol 1992; 148: 2390-2394.
24. Sun Y, Durham SR, Barkans J, et al. T-cells are the principal source of interleukin-5 mRNA in allergen-induced rhinitis. Am J Respir Cell Mol Biol 1993; 9: 356-360.
25. Juniper EF, Frith PA. Dunnett C, Cockcroft DW, Hargreave FE. Reproducibility and comparison of responses to inhaled histamine and methacholine. Thorax 1978; 33: 705-710.
26. NHLBI Workshop Summaries. Summary and recommendations of a workshop of the investigative use of fiberoptic bronchoscopy and bronchoalveolar lavage in asthmatics. Am Rev Respir Dis 1985; 130: 180-182.
27. Robinson DS, Bentley AM, Hartnell A, Kay AB, Durham SR. Activated memory T-helper cells in bronchoalveolar lavage from atopic asthmatics: relationship to asthma symptoms, lung function and bronchial responsiveness. Thorax 1993; 48: 26-32.
28. Mori A, Suko M, Nishizaki Y, et al. IL-5 production by CD4+ T-cells of asthmatic patients is suppressed by glucocorticoids and the immunosuppressants, FK506 and cyclosporin A. Int Immunol 1995; 7: 449-457.
29. Desreumaux P, Janin A, Colombel JF, et al. Interleukin-5 messenger RNA expression by eosinophils in the intestinal mucosa of patients with coeliac disease. J Exp Med 1992; 175: 293-296.
30. Bradding P, Roberts JA, Britten KM, et al. Interleukin-4, -5 and -6 and tumour necrosis factor-α in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am J Respir Cell Mol Biol 1994; 10: 471-480.
31. Desreumaux P, Janin A, Dubucquoi S, et al. Synthesis of interleukin-5 by activated eosinophils in patients with eosinophilic heart diseases. Blood 1993; 82: 1553-1560.
32. Sun Y, Durham SR, Corrigan CJ, Hamid Q, Kay AB. Phenotype of cells expressing mRNA for Th2-type (interleukin-4 and interleukin-5) and Th1-type (interleukin-2 and interferon-γ) cylokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects. Am J Respir Cell Mol Biol 1995; 12: 477-487
33. Djukanovic R, Lai CKW, Wilson JW. Bronchial mucosal manifestations of atopy: a comparison of markers of inflammation between atopic asthmatics, atopic nonasthmatics and healthy controls. Eur Respir J 1992; 5: 538-544.
34. Strickland DH, Kees UR, Holt PG. Suppression of T-cell activation by pulmonary alveolar macrophages: dissociation of effects on TcR, L-2R expression, and proliferation. Eur Respir J 1994; 7: 2124-2130.
35. Gant V, Cluael M, Shakoor Z, Rees PJ, Lee TH, Hamblin AS. Alveolar macrophage accessory cell function in bronchial asthma. Am Rev Respir Dis 1992; 146: 900-904.
36. Sewell WA, Mu HH. Dissociation of production of interleukin-4 and interleukin-5. Immnnol Cell Biology 1996; 74: 274-277.
37. Tang C. Rolland JM, Ward C, Bish R, Thien F, Walters EH. Seasonal comparison of cytokine profiles in atopic asthmatics and atopic nonasthmatics. Am J Respir Crit Care Med 1996; 154: (in press).
38. Robinson DS, Hamid Q, Ying S, et al. Prednisone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-gamma cytokine gene expression. Am Rev Respir Dis 1993; 148: 401-406.
39. Vercelli D, Jabara HH, Lauener RP, Geha RS. IL-4 inhibits the synthesis of IFN-gamma and induces the synthesis of IgE in human mixed lymphocyte cultures. J Immunol 1990; 144: 570-573.