Membrane localization of Src homology 2-containing inositol 5′-phosphatase 2 via Shc association is required for the negative regulation of insulin signaling in Rat1 fibroblasts overexpressing insulin receptors

Molecular Endocrinology

Volumn 16, Issue 10, 2002, Pages 2371-2381

  Ishihara, Hajime ^a,b   Sasaoka, Toshiyasu ^a   Ishiki, Manabu ^a   Wada, Tsutomu ^a   Hori, Hiroyuki ^a   Kagawa, Syota ^a   Kobayashi, Masashi ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b Sainou Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; INSULIN RECEPTOR; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; PROTEIN KINASE B; PROTEIN SHC; PROTEIN SHIP2; SERINE; SRC HOMOLOGY 2 CONTAINING INOSITOL 5' PHOSPHATASE 2; THREONINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FIBROBLAST; HORMONAL REGULATION; MYRISTYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SIGNAL TRANSDUCTION; WILD TYPE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; AMINO ACID SEQUENCE; ANIMALS; ANTISENSE ELEMENTS (GENETICS); CELL MEMBRANE; CELLS, CULTURED; FEEDBACK, BIOCHEMICAL; FIBROBLASTS; HUMANS; INSULIN; MOLECULAR SEQUENCE DATA; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; POINT MUTATION; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECEPTOR, INSULIN; RECOMBINANT PROTEINS; SERINE; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; TYROSINE;

ANIMALIA;

EID: 0036793214     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2002-0083     Document Type: Article

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