A site-specific mutation of tyrosine hydroxylase reduces feedback inhibition by dopamine in genetically modified cells grafted in parkinsonian rats

Journal of Neurochemistry

Volumn 83, Issue 1, 2002, Pages 141-149

  Chang, J W ^a,b   Lee, W Y ^a,c   Milstien, S ^d   Kang, U J ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b Yonsei University College of Medicine   (South Korea)

^c Sungkyunkwan University   (South Korea)

^d NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

6 hydroxydopamine; Aromatic L amino acid decarboxylase; Catecholamine; Gene therapy; Microdialysis; Parkinson's disease

Indexed keywords

AMINO ACID DECARBOXYLASE; DOPAMINE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; LEUCINE; LEVODOPA; MUTANT PROTEIN; SERINE; TETRAHYDROBIOPTERIN; TYROSINE 3 MONOOXYGENASE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL TRANSPLANTATION; COCULTURE; CONTROLLED STUDY; DNA MODIFICATION; FEMALE; FIBROBLAST; GENE MUTATION; GENE THERAPY; MICRODIALYSIS; NEGATIVE FEEDBACK; NONHUMAN; PARKINSONISM; PRIORITY JOURNAL; RAT; RETROVIRUS; VIRUS EXPRESSION; WILD TYPE;

AMINO ACID SUBSTITUTION; ANIMALS; AROMATIC-L-AMINO-ACID DECARBOXYLASES; CATECHOLAMINES; CELLS, CULTURED; COCULTURE TECHNIQUES; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; DOPAMINE; EXTRACELLULAR SPACE; FEEDBACK, BIOCHEMICAL; FEMALE; FIBROBLASTS; GENE THERAPY; GRAFT SURVIVAL; GTP CYCLOHYDROLASE; LEVODOPA; MICRODIALYSIS; MUTAGENESIS, SITE-DIRECTED; PARKINSONIAN DISORDERS; RATS; RATS, INBRED F344; TRANSDUCTION, GENETIC; TYROSINE 3-MONOOXYGENASE;

ANIMALIA; PARKINSONIA; UNIDENTIFIED RETROVIRUS;

EID: 0036789661     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.01120.x     Document Type: Article

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