The localization and functional contribution of striatal aromatic L-amino acid decarboxylase to L-3,4-Dihydroxyphenylalanine decarboxylation in rodent Parkinsonian models

Cell Transplantation

Volumn 9, Issue 5, 2000, Pages 567-576

  Nakamura, Ken ^a   Ahmed, Maqbool ^a   Barr, Eliav ^a,b   Leiden, Jeffrey M ^a,c   Kang, Un Jung ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Aromatic L amino acid decarboxylase; Decarboxylation; Glia; L 3,4 Dihydroxyphenylalanine; Parkinson's disease; Striatum

Indexed keywords

AROMATIC LEVO AMINO ACID DECARBOXYLASE; DOPAMINE; LEVODOPA; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; CONTROLLED STUDY; CORPUS STRIATUM; DECARBOXYLATION; DOPAMINE METABOLISM; DOPAMINERGIC NERVE CELL; DRUG EFFECT; ENZYME ACTIVITY; ENZYME LOCALIZATION; FEMALE; GLIA; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT OUTCOME;

ADENOVIRIDAE; ANIMALIA; PARKINSONIA; RODENTIA;

EID: 0034532928     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.1177/096368970000900502     Document Type: Conference Paper

References (39)

1. Effects of L-DOPA on extracellular dopamine in striatum of normal and 6-hydroxydopamine-treated rats
2. Distinct promoters direct neuronal and nonneuronal expression of rat aromatic L-amino acid decarboxylase
3. L-DOPA is converted to dopamine in serotonergic fibers of the striatum of the rat: A double-labeling immunofluorescence study
4. Aromatic L-amino acid decarboxylase is present in serotonergic fibers of the striatum of the rat. A double-labeling immunofluorescence study
5. Aromatic L-amino acid decarboxylase: Biochemicstry and functional significance
6. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
7. Distribution of aromatic L-amino acid decarboxylase mRNA in mouse brain by in situ hybridization histology
8. An HSV-I vector expressing tyrosine hydroxylase causes production and release of L-DOPA from cultured rat striatal cells
9. Structure of the rat aromatic L-amino acid decarboxylase gene: Evidence for an alternative promoter usage
10. The site of dopamine formation in rat striatum after L-dopa administration
11. Demonstration of L-dopa decarboxylating neurons specific to human striatum
12. Immunocytochemical localization of aromatic L-amino acid decarboxylase
13. Decarboxylation of L-dopa by cultured mouse astrocytes
14. Absence of decarboxylation of some aromatic-L-amino acids by cultured astrocytes
15. Regulation of dopamine production by genetically modified primary fibroblasts
16. DOPA-decarboxylation in the striata of rats with unilateral substantia nigra lesions
17. The first intron of the 4F2 heavy-chain gene contains a transcriptional enhancer element that binds multiple nuclear protein
18. Use of the human elongation factor I alpha promoter as a versatile and efficient expression system
19. Vesicular monoamine transporter-2 and aromatic L-amino acid decarboxylase enhance dopamine delivery after L-3,4-dihydroxyphenylalanine administration in parkinsonian rats
20. Long-term restoration of striatal L-aromatic amino acid decarboxylase activity using recombinant adeno-associated viral vector gene transfer in a rodent model of Parkinson's disease
21. Gene expression of aromatic L-amino acid decarboxylase in cultured rat glial cells
22. Occurrence and distribution of aromatic L-amino acid (L-DOPA) decarboxylase in the human brain
23. Generation of DOPA-producing astrocytes by retroviral transduction of the human tyrosine hydroxylase gene: In vitro characterization and in vivo effects in the rat Parkinson model
24. In vivo electrochemical measurements and electrophysiological studies of rat striatum following neonatal 6-hydroxydopamine treatment
25. Regional distribution of enzymes associated with neurotransmission by monoamines, acetylcholine and GABA in the human brain
26. Aromatic L-amino acid decarboxylase in rat corpus striatum: Implications for action of L-DOPA in parkinsonism
27. Is L-dopa an endogenous neurotransmitter?
28. Dopamine formation from L-DOPA administered exogenously is independent of dopaminergic neuronal activity: Studies with in vivo microdialysis
29. Aromatic L-amino acid decarboxylase immunoreactive cells in the rat striatum: A possible site for the conversion of exogenous L-DOPA to dopamine
30. Demonstration of aromatic L-amino acid decarboxylase activity in human brain with L-DOPA and L-5-hydroxytryptophan as substrates by high-performance liquid chromatography with electrochemical detection
31. Volume transmission of dopamine over large distances may contribute to recovery from experimental parkinsonism
32. Analysis of the alternative promoters that regulate tissue-specific expression of human aromatic L-amino acid decarboxylase
33. A nonneuronal isoform of cell adhesion molecule L1: Tissue specific expression and functional analysis
34. Striatal neurons with aromatic L-amino acid decarboxylase-like immunoreactivity in the rat
35. Clearance and diffusion of locally applied dopamine in normal and 6-hydroxydopamine-treated rats by intracerebral grafting of fibroblasts transfected with tyrosine hydroxylase cDNA
36. The role of aromatic L-amino acid decarboxylase for dopamine replacement by genetically modified fibroblasts in a rat model of Parkinson's disease
37. Effects of gliosis on dopamine metabolism in rat striatum
38. Rapid serotonergic fiber sprouting in response to ibotenic acid lesion in the striatum and hippocampus
39. Serotonergic sprouting is induced by dopamine-lesion in substantia nigra of adult rat brain