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Volumn 25, Issue 3, 2002, Pages 251-259

Cerulein-induced acute pancreatitis in the rat is significantly ameliorated by treatment with MEK1/2 inhibitors U0126 and PD98059

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; AMYLASE; CERULETIDE; ENZYME INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE; VINBLASTINE;

EID: 0036786851     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-200210000-00007     Document Type: Article
Times cited : (61)

References (34)
  • 1
    • 0025315315 scopus 로고
    • Experimental models of acute pancreatitis
    • Bilchik AJ, Leach SD, Zucker KA, et al. Experimental models of acute pancreatitis. J Surg Res 1990;48:639-47.
    • (1990) J Surg Res , vol.48 , pp. 639-647
    • Bilchik, A.J.1    Leach, S.D.2    Zucker, K.A.3
  • 2
    • 0031897012 scopus 로고    scopus 로고
    • Pharmaceutical development for treating pancreatic diseases
    • Kitagawa M, Naruse S, Ishiguro H, et al. Pharmaceutical development for treating pancreatic diseases. Pancreas 1998;16:427-31.
    • (1998) Pancreas , vol.16 , pp. 427-431
    • Kitagawa, M.1    Naruse, S.2    Ishiguro, H.3
  • 3
    • 0028069434 scopus 로고
    • Lipid mediator production in acute and chronic pancreatitis in the rat
    • Zhou W, Levine BA, Olson MS. Lipid mediator production in acute and chronic pancreatitis in the rat. J Surg Res 1994;56:37-44.
    • (1994) J Surg Res , vol.56 , pp. 37-44
    • Zhou, W.1    Levine, B.A.2    Olson, M.S.3
  • 4
    • 0030066892 scopus 로고    scopus 로고
    • Evidence for altered cellular calcium in the pathogenetic mechanism of acute pancreatitis in rats
    • Zhou W, Shen F, Miller JE, et al. Evidence for altered cellular calcium in the pathogenetic mechanism of acute pancreatitis in rats. J Surg Res 1996;60:147-55.
    • (1996) J Surg Res , vol.60 , pp. 147-155
    • Zhou, W.1    Shen, F.2    Miller, J.E.3
  • 5
    • 0030024316 scopus 로고    scopus 로고
    • Hormonal stimulation of calcium mobilization in the isolated perfused rat pancreas
    • Zhou W, Shen F, Miller JE, et al. Hormonal stimulation of calcium mobilization in the isolated perfused rat pancreas. J Surg Res 1996;60:168-75.
    • (1996) J Surg Res , vol.60 , pp. 168-175
    • Zhou, W.1    Shen, F.2    Miller, J.E.3
  • 6
    • 0030720786 scopus 로고    scopus 로고
    • Cholecystokinin and EGF activate a MAPK cascade by different mechanisms in rat pancreatic acinar cells
    • Dabrowski A, Groblewski GE, Schafer C, et al. Cholecystokinin and EGF activate a MAPK cascade by different mechanisms in rat pancreatic acinar cells. Am J Physiol 1997;273:C1472-9.
    • (1997) Am J Physiol , vol.273
    • Dabrowski, A.1    Groblewski, G.E.2    Schafer, C.3
  • 7
    • 0028156378 scopus 로고
    • Cholecystokinin rapidly activates mitogen-activated protein kinase in rat pancreatic acini
    • Duan RD, Williams JA. Cholecystokinin rapidly activates mitogen-activated protein kinase in rat pancreatic acini. Am J Physiol 1994;267:G401-8.
    • (1994) Am J Physiol , vol.267
    • Duan, R.D.1    Williams, J.A.2
  • 8
    • 0028835482 scopus 로고
    • Activation of MAP kinase kinase (MEK) and Ras by cholecystokinin in rat pancreatic acini
    • Duan RD, Zheng CF, Guan KL, et al. Activation of MAP kinase kinase (MEK) and Ras by cholecystokinin in rat pancreatic acini. Am J Physiol 1995;268: G1060-5.
    • (1995) Am J Physiol , vol.268
    • Duan, R.D.1    Zheng, C.F.2    Guan, K.L.3
  • 9
    • 0030900843 scopus 로고    scopus 로고
    • CCK activates p90rsk in rat pancreatic acini through protein kinase C
    • Bragado MJ, Dabrowski A, Groblewski GE, et al. CCK activates p90rsk in rat pancreatic acini through protein kinase C. Am J Physiol 1997;272:G401-7.
    • (1997) Am J Physiol , vol.272
    • Bragado, M.J.1    Dabrowski, A.2    Groblewski, G.E.3
  • 10
    • 0034811165 scopus 로고    scopus 로고
    • Smad4 mediates activation of mitogenactivated protein kinases by TGF-beta in pancreatic acinar cells
    • Simeone DM, Zhang L, Graziano K, et al. Smad4 mediates activation of mitogenactivated protein kinases by TGF-beta in pancreatic acinar cells. Am J Physiol Cell Physiol 2001;281:C311-9.
    • (2001) Am J Physiol Cell Physiol , vol.281
    • Simeone, D.M.1    Zhang, L.2    Graziano, K.3
  • 11
    • 0029864407 scopus 로고    scopus 로고
    • Jun kinases are rapidly activated by cholecystokinin in rat pancreas both in vitro and in vivo
    • Dabrowski A, Grady T, Logsdon CD, et al. Jun kinases are rapidly activated by cholecystokinin in rat pancreas both in vitro and in vivo. J Biol Chem 1996;271: 5686-90.
    • (1996) J Biol Chem , vol.271 , pp. 5686-5690
    • Dabrowski, A.1    Grady, T.2    Logsdon, C.D.3
  • 12
    • 0033373475 scopus 로고    scopus 로고
    • HSP27 expression regulates CCK-induced changes of the actin cytoskeleton in CHO-CCK-A cells
    • Schafer C, Clapp P, Welsh MJ, et al. HSP27 expression regulates CCK-induced changes of the actin cytoskeleton in CHO-CCK-A cells. Am J Physiol 1999;277: C1032-43.
    • (1999) Am J Physiol , vol.277
    • Schafer, C.1    Clapp, P.2    Welsh, M.J.3
  • 13
    • 0032893960 scopus 로고    scopus 로고
    • p38 map kinase is expressed in the pancreas and is immediately activated following cerulein hyperstimulation
    • Wagner AC, Metzler W, Hofken T, et al. p38 Map kinase is expressed in the pancreas and is immediately activated following cerulein hyperstimulation. Digestion 1999;60:41-7.
    • (1999) Digestion , vol.60 , pp. 41-47
    • Wagner, A.C.1    Metzler, W.2    Hofken, T.3
  • 14
    • 0035111692 scopus 로고    scopus 로고
    • Somatostatin inhibits Akt phosphorylation and cell cycle entry, but not p42/p44 mitogen-activated protein (MAP) kinase activation in normal and tumoral pancreatic acinar cells
    • Charland S, Boucher MJ, Houde M, et al. Somatostatin inhibits Akt phosphorylation and cell cycle entry, but not p42/p44 mitogen-activated protein (MAP) kinase activation in normal and tumoral pancreatic acinar cells. Endocrinology 2001;142:121-8.
    • (2001) Endocrinology , vol.142 , pp. 121-128
    • Charland, S.1    Boucher, M.J.2    Houde, M.3
  • 15
    • 0030567987 scopus 로고    scopus 로고
    • Stress-activated protein kinase activation is the earliest direct correlate to the induction of secretagogue-induced pancreatitis in rats
    • Grady T, Dabrowski A, Williams JA, et al. Stress-activated protein kinase activation is the earliest direct correlate to the induction of secretagogue-induced pancreatitis in rats. Biochem Biophys Res Commun 1996;227:1-7.
    • (1996) Biochem Biophys Res Commun , vol.227 , pp. 1-7
    • Grady, T.1    Dabrowski, A.2    Williams, J.A.3
  • 16
    • 0031956424 scopus 로고    scopus 로고
    • PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase
    • Reiners JJ Jr, Lee JY, Clift RE, et al. PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase. Mol Pharmacol 1998;53:438-45.
    • (1998) Mol Pharmacol , vol.53 , pp. 438-445
    • Reiners J.J., Jr.1    Lee, J.Y.2    Clift, R.E.3
  • 17
    • 0032552994 scopus 로고    scopus 로고
    • MEK inhibitors: The chemistry and biological activity of U0126, its analogs, and cyclization products
    • Duncia JV, Santella JB 3rd, Higley CA, et al. MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products. Bioorg Med Chem Lett 1998;8:2839-44.
    • (1998) Bioorg Med Chem Lett , vol.8 , pp. 2839-2844
    • Duncia, J.V.1    Santella J.B. III2    Higley, C.A.3
  • 18
    • 0033954869 scopus 로고    scopus 로고
    • CEP-1347 inhibits caeruleininduced rat pancreatic JNK activation and ameliorates caerulein pancreatitis
    • Wagner AC, Mazzucchelli L, Miller M, et al. CEP-1347 inhibits caeruleininduced rat pancreatic JNK activation and ameliorates caerulein pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2000;278:GI65-72.
    • (2000) Am J Physiol Gastrointest Liver Physiol , vol.278
    • Wagner, A.C.1    Mazzucchelli, L.2    Miller, M.3
  • 19
    • 0032795940 scopus 로고    scopus 로고
    • The mitogen-activated protein kinase kinase/extracellular signal-regulated kinase cascade activation is a key signalling pathway involved in the regulation of G(1) phase progression in proliferating hepatocytes
    • Talarmin H, Rescan C, Cariou S, et al. The mitogen-activated protein kinase kinase/extracellular signal-regulated kinase cascade activation is a key signalling pathway involved in the regulation of G(1) phase progression in proliferating hepatocytes. Mol Cell Biol 1999;19:6003-11.
    • (1999) Mol Cell Biol , vol.19 , pp. 6003-6011
    • Talarmin, H.1    Rescan, C.2    Cariou, S.3
  • 20
    • 0034669187 scopus 로고    scopus 로고
    • N-methyl-D-aspartate receptors and p38 mitogen-activated protein kinase are required for cAMP-dependent cyclase response element binding protein and Elk-1 phosphorylation in the striatum
    • Choe ES, McGinty JF. N-Methyl-D-aspartate receptors and p38 mitogen-activated protein kinase are required for cAMP-dependent cyclase response element binding protein and Elk-1 phosphorylation in the striatum. Neuroscience 2000;101:607-17.
    • (2000) Neuroscience , vol.101 , pp. 607-617
    • Choe, E.S.1    McGinty, J.F.2
  • 21
    • 0033842563 scopus 로고    scopus 로고
    • Inhibition of the ER-kinase cascade by PD98059 and U0126 counteracts ischemic preconditioning in pig myocardium
    • Strohm C, Barancik T, Bruhl ML, et al. Inhibition of the ER-kinase cascade by PD98059 and U0126 counteracts ischemic preconditioning in pig myocardium. J Cardiovasc Pharmacol 2000;36:218-29.
    • (2000) J Cardiovasc Pharmacol , vol.36 , pp. 218-229
    • Strohm, C.1    Barancik, T.2    Bruhl, M.L.3
  • 22
    • 0034673214 scopus 로고    scopus 로고
    • Inhibition of MAP kinase kinase (MEK) results in an anti-inflammatory response in vivo
    • Jaffee BD, Manos EJ, Collins RJ, et al. Inhibition of MAP kinase kinase (MEK) results in an anti-inflammatory response in vivo. Biochem Biophys Res Commun 2000;268:647-51.
    • (2000) Biochem Biophys Res Commun , vol.268 , pp. 647-651
    • Jaffee, B.D.1    Manos, E.J.2    Collins, R.J.3
  • 23
    • 0035136594 scopus 로고    scopus 로고
    • Neuroprotection by estrogen via extracellular signal-regulated kinase against quinolinic acid-induced cell death in the rat hippocampus
    • Kuroki Y, Fukushima K, Kanda Y, et al. Neuroprotection by estrogen via extracellular signal-regulated kinase against quinolinic acid-induced cell death in the rat hippocampus. Eur J Neurosci 2001;13:472-6.
    • (2001) Eur J Neurosci , vol.13 , pp. 472-476
    • Kuroki, Y.1    Fukushima, K.2    Kanda, Y.3
  • 24
    • 0027755217 scopus 로고
    • Platelet-activating factor: A mediator of pancreatic inflammation during cerulein hyperstimulation
    • Zhou W, Levine BA, Olson MS. Platelet-activating factor: a mediator of pancreatic inflammation during cerulein hyperstimulation. Am J Pathol 1993;142: 1504-12.
    • (1993) Am J Pathol , vol.142 , pp. 1504-1512
    • Zhou, W.1    Levine, B.A.2    Olson, M.S.3
  • 25
    • 0018774809 scopus 로고
    • Neutropenia, inflammation, and the kinetics of transfused neutrophils in rabbits
    • Rosenshein MS, Price TH, Dale DC. Neutropenia, inflammation, and the kinetics of transfused neutrophils in rabbits. J Clin Invest 1979;64:580-5.
    • (1979) J Clin Invest , vol.64 , pp. 580-585
    • Rosenshein, M.S.1    Price, T.H.2    Dale, D.C.3
  • 26
    • 0020533776 scopus 로고
    • The biologic activity of mast cell granules. VI. The effect of vinblastine-induced neutropenia on rat cutaneous late phase reactions
    • Lemanske RF Jr, Guthman DA, Oertel H, et al. The biologic activity of mast cell granules. VI. The effect of vinblastine-induced neutropenia on rat cutaneous late phase reactions. J Immunol 1983;130:2837-42.
    • (1983) J Immunol , vol.130 , pp. 2837-2842
    • Lemanske R.F., Jr.1    Guthman, D.A.2    Oertel, H.3
  • 27
    • 0026784185 scopus 로고
    • Effect of platelet-activating factor antagonist and leukotriene antagonist on endotoxin shock in the rat: Role of the leukocyte
    • Yoshikawa D, Goto F. Effect of platelet-activating factor antagonist and leukotriene antagonist on endotoxin shock in the rat: role of the leukocyte. Circ Shock 1992;38:29-33.
    • (1992) Circ Shock , vol.38 , pp. 29-33
    • Yoshikawa, D.1    Goto, F.2
  • 28
    • 0033609825 scopus 로고    scopus 로고
    • Stimulation of mitogen-activated protein kinase by G protein-coupled alpha(2)-adrenergic receptors does not require agonist-elicited endocytosis
    • Schramm NL, Limbird LE. Stimulation of mitogen-activated protein kinase by G protein-coupled alpha(2)-adrenergic receptors does not require agonist-elicited endocytosis. J Biol Chem 1999;274:24935-40.
    • (1999) J Biol Chem , vol.274 , pp. 24935-24940
    • Schramm, N.L.1    Limbird, L.E.2
  • 29
    • 0034817383 scopus 로고    scopus 로고
    • Ionomycin causes activation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils
    • Elzi DJ, Bjornsen AJ, MacKenzie T, et al. Ionomycin causes activation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils. Am J Physiol Cell Physiol 2001;281:C350-60.
    • (2001) Am J Physiol Cell Physiol , vol.281
    • Elzi, D.J.1    Bjornsen, A.J.2    MacKenzie, T.3
  • 30
    • 0029841658 scopus 로고    scopus 로고
    • The role of neutrophils and plateletactivating factor in mediating experimental pancreatitis
    • Sandoval D, Gukovskaya A, Reavey P, et al. The role of neutrophils and plateletactivating factor in mediating experimental pancreatitis. Gastroenterology 1996; 111:1081-91.
    • (1996) Gastroenterology , vol.111 , pp. 1081-1091
    • Sandoval, D.1    Gukovskaya, A.2    Reavey, P.3
  • 31
    • 0030820039 scopus 로고    scopus 로고
    • Role of neutrophils in cerulein-induced pancreatitis in rats: Possible involvement of apoptosis
    • Fujimoto K, Hosotani R, Doi R, et al. Role of neutrophils in cerulein-induced pancreatitis in rats: possible involvement of apoptosis. Digestion 1997;58: 421-30.
    • (1997) Digestion , vol.58 , pp. 421-430
    • Fujimoto, K.1    Hosotani, R.2    Doi, R.3
  • 32
    • 0032908128 scopus 로고    scopus 로고
    • Bone morphogenetic protein 2 exerts diverse effects on cell growth in vitro and is expressed in human pancreatic cancer in vivo
    • Kleeff J, Maruyama H, Ishiwata T, et al. Bone morphogenetic protein 2 exerts diverse effects on cell growth in vitro and is expressed in human pancreatic cancer in vivo. Gastroenterology 1999;116:1202-16.
    • (1999) Gastroenterology , vol.116 , pp. 1202-1216
    • Kleeff, J.1    Maruyama, H.2    Ishiwata, T.3
  • 33
    • 0033991167 scopus 로고    scopus 로고
    • Concomitant over-expression of vascular endothelial growth factor and its receptors in pancreatic cancer
    • Itakura J, Ishiwata T, Shen B, et al. Concomitant over-expression of vascular endothelial growth factor and its receptors in pancreatic cancer. Int J Cancer 2000;85:27-34.
    • (2000) Int J Cancer , vol.85 , pp. 27-34
    • Itakura, J.1    Ishiwata, T.2    Shen, B.3
  • 34
    • 0035545994 scopus 로고    scopus 로고
    • 12-Lipoxygenase metabolite 12(S)-HETE stimulates human pancreatic cancer cell proliferation via protein tyrosine phosphorylafion and ERK activation
    • Ding X-Z, Tong WG, Adrian TE. 12-Lipoxygenase metabolite 12(S)-HETE stimulates human pancreatic cancer cell proliferation via protein tyrosine phosphorylafion and ERK activation. Int J Cancer 2001;94:630-6.
    • (2001) Int J Cancer , vol.94 , pp. 630-636
    • Ding, X.-Z.1    Tong, W.G.2    Adrian, T.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.