OX40 signaling renders adult T-cell leukemia cells resistant to fas-induced apoptosis

International Journal of Hematology

Volumn 76, Issue 3, 2002, Pages 260-266

  Kunitomi, Akane ^a   Hori, Toshiyuki ^a   Maeda, Michiyuki ^b   Uchiyama, Takashi ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Apoptosis; ATL; OX40

Indexed keywords

CD134 ANTIGEN; INTERLEUKIN 2; MONOCLONAL ANTIBODY; CD27 ANTIGEN; FAS ANTIGEN; TNFRSF4 PROTEIN, HUMAN; TNFRSF4 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR RECEPTOR;

APOPTOSIS; ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; GENE DELETION; GENE MUTATION; HUMAN; HUMAN T CELL LEUKEMIA VIRUS; IMMUNE SYSTEM; T LYMPHOCYTE; ADULT; AGED; CELL CULTURE; FEMALE; FLOW CYTOMETRY; GENETIC TRANSFECTION; IMMUNOLOGY; MALE; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; T CELL LYMPHOMA;

ADULT; AGED; ANTIGENS, CD27; ANTIGENS, CD95; APOPTOSIS; FEMALE; FLOW CYTOMETRY; HUMANS; LEUKEMIA-LYMPHOMA, T-CELL, ACUTE, HTLV-I-ASSOCIATED; MALE; MIDDLE AGED; RECEPTORS, OX40; RECEPTORS, TUMOR NECROSIS FACTOR; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0036781337     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02982796     Document Type: Article

References (46)

1. Uchiyama T, Yodoi J, Sagawa K, Takatsuki K, Uchino H. Adult T cell leukemia: clinical and hematologic features of 16 cases. Blood. 1977;50:481-492.
2. Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC. Detection and isolation of type-C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci U S A. 1980;77:7415-7419.
3. Uchiyama T. Human T cell leukemia virus type I (HTLV-I) and human diseases. Annu Rev Immunol. 1997;15:15-37.
4. Yamaguchi K. Human T-lymphotropic virus type I in Japan. Lancet. 1994;343:213-216.
5. Imura A, Hori T, Imada K, et al. OX40 expressed on fresh leukemic cells from adult T-cell leukemia patients mediates cell adhesion to vascular endothelial cells: implication for the possible involvement of OX40 in leukemic cell infiltration. Blood. 1997;89:2951-2958.
6. Tanaka Y, Inoi T, Tozawa H, Yamamoto N, Hinuma Y. A glycoprotein antigen detected with new monoclonal antibodies on the surface of human lymphocytes infected with human T-cell leukemia virus type-I (HTLV-I). Int J Cancer. 1985;36:549-555.
7. Tozawa H, Andoh S, Takayama Y, et al. Species-dependent antigenicity of the 34-kDa glycoprotein found on the membrane of various primate lymphocytes transformed by human T-cell leukemia virus type-I (HTLV-I) and simian T-cell leukemia virus (STLV-I). Int J Cancer. 1988;41:231-238.
8. tax. Mol Cell Biol. 1991;11:1313-1325.
9. Paterson DJ, Jefferies WA, Green JR, et al. Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts. Mol Immunol. 1987;24:1281-1290.
10. Mallett S, Fossum S, Barclay AN. Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes - a molecule related to nerve growth factor receptor. EMBO J. 1990;9:1063-1068.
11. Calderhead DM, Buhlmann JE, van den Eertwegh AJM, Claassen E, Noelle RJ, Fell HP. Cloning of mouse OX40: a T cell activation marker that may mediate T-B cell interactions. J Immunol. 1993;151:5261-5271.
12. Latza U, Durkop H, Schnittger S, et al. The human OX40 homolog: cDNA structure, expression and chromosomal assignment of the ACT35 antigen. Eur J Immunol. 1994;24:677-683.
13. Gruss HJ, Dower SK. Tumor necrosis factor ligand superfamily: involvement in pathology of malignant lymphomas. Blood. 1995;85:3378-3404.
14. Beg AA, Baltimore D. An essential role for NF-κB in preventing TNF-α-induced cell death. Science. 1996;274:782-784.
15. Liu ZG, Hsu H, Goeddel DV, Karin M. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell. 1996;87:565-576.
16. Van AD, Martin SJ, Kafri T, Green DR, Verma IM. Suppression of TNF-α-induced apoptosis by NF-κB. Science. 1996;274:787-789.
17. Sha WC. Regulation of immune responses by NF-KB/Rel transcription factors. J Exp Med. 1998;187:143-146.
18. Kawamata S, Hori T, Imura A, Takaori-Kondo A, Uchiyama T. Activation of OX40 signal transduction pathways leads to TRAF2-and TRAF5-mediated NF-κB activation. J Biol Chem. 1998;273:5808-5814.
19. Kunitomi A, Hori T, Imura A, Uchiyama T. Vascular endothelial cells provide T cells with costimulatory signals via the OX40/gp34 system. J Leukoc Biol. 2000;67:111-118.
20. Hori T, Uchiyama T, Tsudo M, et al. Establishment of an interleukin 2-dependent human T cell line from a patient with T cell chronic lymphocyte leukemia who is not infected with human T cell leukemia/lymphoma virus. Blood. 1987;70:1069-1072.
21. Matsumura Y, Hori T, Kawamata S, Imura A, Uchiyama T. Intracellular signaling of gp34, the OX40 ligand: induction of c-jun and c-fos mRNA expression through gp34 upon binding of its receptor, OX40. J Immunol. 1999;163:3007-3011.
22. Koopman G, Reutelingsperger CPM, Kuijten GAM, Keehnen RMJ, Pals ST, van Oers MHJ. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood. 1994;84:1415-1420.
23. Ishikawa T, Imura A, Tanaka H, Shirane H, Okuma M, Uchiyama T. E-selectin and vascular cell adhesion molecule-1 mediate adult T cell leukemia cell adhesion to endothelial cells. Blood. 1993;82:1590-1598.
24. Parker CE, Nightingale S, Taylor GP, Weber J, Bangham CR. Circulating anti-Tax cytotoxic T lymphocytes from human T-cell leukemia virus type I-infected people, with and without tropical spastic paraparesis, recognize multiple epitopes simultaneously. J Virol. 1994;68:2860-2868.
25. Tamiya S, Etoh K, Suzushima H, Takatsuki K, Matsuoka M. Mutation of CD95 (Fas/Apo-1) gene in adult T-cell leukemia cells. Blood. 1998;91:3935-3842.
26. Copeland KFT, Haaksma AGM, Goudsmit J, Krammer PH, Heeney JL. Inhibition of apoptosis in T cells expressing human T cell leukemia virus type I Tax. AIDS Res Hum Retroviruses. 1994;10:1259-1268.
27. Pimentel-Muiños FX, Seed B. Regulated commitment of TNF receptor signaling: a molecular switch for death or activation. Immunity. 1999;11:783-793.
28. Baldwin ASJ. The NF-κB and IκB proteins: new discoveries and insights. Annu Rev Immunol. 1996;14:649-681.
29. Hsu H, Xiong J, Goeddel DV. The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation. Cell. 1995;81:495-504.
30. Hsu H, Shu HB, Pan MG, Goeddel DV. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell. 1996;84:299-308.
31. Mori N, Fujii M, Ikeda S, et al. Constitutive activation of NF-κB in primary adult T-cell leukemia cells. Blood. 1999;93:2360-2368.
32. Nakamura M, Takasawa N, Ohbo K, et al. HTLV-I Tax transactivation and cell growth signaling. Leukemia. 1997;3:7-9.
33. Higashimura N, Takasawa N, Tanaka Y, Nakamura M, Sugamura K. Induction of OX40, a receptor of gp34, on T cells by trans-acting transcriptional activator, Tax, of human T-cell leukemia virus type I. Jpn J Cancer Res. 1996;87:227-231.
34. Kato T, Furumoto H, Kamada M, et al. Immunological functions of adult T cell leukemia cells of a patient complicated with synchronous double primary gynecologic cancer. J Med Invest. 1997;44:99-102.
35. Kamihara S, Yamada Y, Tomonaga M, Sugahara K, Tsuruda K. Discrepant expression of membrane and soluble isoforms of Fas(CD95/APO-1) in adult T-cell leukemia: soluble Fas isoform is an independent risk factor for prognosis. Br J Haematol 1999;107:851-860.
36. Jeffrey SF, Underbill LH. The tumor necrosis factor ligand and receptor families. New Engl J Med. 1996;334:1717-1725.
37. Khoshnan A, Tindell C, Laux I, Bae D, Bennet B, Nel AE.The NF-κB cascade is important in Bcl-xL expression and for the antiapoptotic effects of the CD28 receptor in primary human CD4+ lymphocytes. J Immunol. 2000;165:1743-1754.
38. Rogers PR, Song J, Gramaglia I, Killeen N, Groft M. OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4T cells. Immunity. 2001;15:445-455.
39. Baum PR, Gayle RB III, Ramsdell F, et al. Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-I-regulated protein gp34. EMBO J. 1994;13:3992-4001.
40. + T cells with homology to tumor necrosis factor. J Exp Med. 1994;180:757-762.
41. Imura A, Hori T, Imada K, et al. The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells. J Exp Med. 1996;183:2185-2195.
42. Chen AI, McAdam AJ, Buhlmann JE, et al. OX40-ligand has a critical costimulatory role in dendritic cell: T cell interactions. Immunity. 1999;11:689-698.
43. Kopf M, Ruedl C, Schmitz N, et al. OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL responses after virus infection. Immunity. 1999;11:699-708.
44. Akiba H, Oshima H, Takeda K, et al. CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells. J Immunol. 1999;162:7058-7066.
45. Murata K, Ishii N, Takano H, et al. Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand. J Exp Med. 2000;91:365-374.
46. Peter L. Role of OX40 signals in coordinating CD4 T cell selection, migration, and cytokine differentiation in T helper (Th)1 and Th2 cells. J Exp Med. 2000;191:201-206.