Production of avirulent mutants of Mycobacterium bovis with vaccine properties by the use of illegitimate recombination and screening of stationary-phase cultures

Microbiology

Volumn 148, Issue 10, 2002, Pages 3019-3027

  Collins, D M ^a   Wilson, T ^a   Campbell, S ^a   Buddle, B M ^a   Wards, B J ^a   Hotter, G ^a   de Lisle, G W ^a  

^a AGRESEARCH   (New Zealand)

Author keywords

BCG; Guinea pig; Mycobacterium tuberculosis; Tuberculosis; Vaccines; Virulence

Indexed keywords

BCG VACCINE; DNA FRAGMENT; GLUCOSE; GLUTAMATE AMMONIA LIGASE; KANAMYCIN; LIVE VACCINE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); SIGMA FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL VIRULENCE; BACTERIUM CULTURE; BACTERIUM MUTANT; CATALYSIS; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; DNA RECOMBINATION; DRUG EFFICACY; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENETIC SCREENING; GLUCONEOGENESIS; GUINEA PIG; INOCULATION; MYCOBACTERIUM BOVIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STRAIN DIFFERENCE; TUBERCULOSIS; TUBERCULOSIS CONTROL;

ACTINOBACTERIA (CLASS); ANIMALIA; BACTERIA (MICROORGANISMS); CAVIA; CAVIA PORCELLUS; MYCOBACTERIUM; MYCOBACTERIUM BOVIS; MYCOBACTERIUM BOVIS BCG; MYCOBACTERIUM TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS COMPLEX; SUS SCROFA; UNCULTURED ACTINOMYCETE;

EID: 0036775825     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/00221287-148-10-3019     Document Type: Article

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