An esat6 knockout mutant of Mycobacterium bovis produced by homologous recombination will contribute to the development of a live tuberculosis vaccine

Tubercle and Lung Disease

Volumn 80, Issue 4-5, 2000, Pages 185-189

  Wards, B J ^a   De Lisle, G W ^a   Collins, D M ^a  

^a AGRESEARCH   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE;

ANIMAL CELL; ARTICLE; BACTERIAL VIRULENCE; BCG VACCINATION; CONTROLLED STUDY; GENE DELETION; INTRACUTANEOUS TEST; KNOCKOUT GENE; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; STRAIN DIFFERENCE; TUBERCULOSIS; VACCINE PRODUCTION;

EID: 0033740251     PISSN: 09628479     EISSN: None     Source Type: Journal    
DOI: 10.1054/tuld.2000.0244     Document Type: Article

References (17)

1. Vaccination of guinea pigs with nutritionally impaired avirulent mutants of Mycobacterium bovis protects against tuberculosis
2. Auxotrophic vaccines for tuberculosis
3. Persistence and protective efficacy of a Mycobacterium tuberculosis auxotroph vaccine
4. Molecular approaches to the diagnosis of tuberculosis
5. Cellular immune response to ESAT-6 discriminate between patients with pulmonary disease due to Mycobacterium avium complex and those with pulmonary disease due to Mycobacterium tuberculosis
6. Differential T cell responses to Mycobacterium tuberculosis ESAT6 in tuberculosis patients and healthy donors
7. Differentiation between Mycobacterium bovis BCG-vaccinated and M. bovis-infected cattle by using recombinant mycobacterial antigens
8. The potential of the ESAT-6 antigen secreted by virulent mycobacteria for specific diagnosis of tuberculosis
9. Human T cell response to the ESAT-6 antigen from Mycobacterium tuberculosis
10. Delayed-type hypersensitivity responses to ESAT-6 and MPT64 from Mycobacterium tuberculosis in the guinea pig
11. Isolation and expression of a gene cluster responsible for biosynthesis of the glycopeptidolipid antigens of Mycobacterium avium
12. Electroporation at elevated temperatures substantially improves transformation efficiency of slow-growing mycobacteria
13. Occurrence and stability of insertion sequences in Mycobacterium tuberculosis complex strains: Evaluation of an insertion-sequence dependent DNA polymorphism as a tool in the epidemiology of tuberculosis
14. Production of avirulent Mycobacterium strains by illegitimate recombination with deoxyribonucleic acid fragments containing an interrupted ahpC gene
15. B-cell epitopes and quantification of the ESAT-6 protein of Mycobacterium tuberculosis
16. Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis
17. A Mycobacterium tuberculosis operon encoding ESAT-6 and a novel low-molecular-mass culture filtrate protein (CFP-10)